Sensitization to per a 2 of the American cockroach correlates with more clinical severity among airway allergic patients in Taiwan

Lee, Mey Fann; Song, Pei Peng; Hwang, Guang-Yuh; Lin, Shyh Jye; Chen, Yi Hsing

doi:10.1016/j.anai.2012.01.014

Cited by 47 publications

(43 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Asia, cockroach allergens are found in 11% to 98% of dust samples collected from 9 cities across the southern and tropical regions of China (16). In Taiwan, 58% of asthmatic patients are allergic to the cockroach allergen, Per a 2 (17). These studies implicated that cockroach allergens exposure and sensitization are clinically relevant across multiple continents.…”

Section: Introductionmentioning

confidence: 99%

Cockroach allergen exposure and risk of asthma

Danh

Zhao

Gao

2016

Allergy

135

View full text Add to dashboard Cite

Cockroach sensitization is an important risk factor for the development of asthma. However, its underlying immune mechanisms and the genetic etiology for differences in allergic responses remain unclear. Cockroach allergens identification and their expression as biologically active recombinant proteins has provided a basis for studying the mechanisms regarding cockroach allergens induced allergic sensitization and asthma. Glycans in allergens may play a crucial role in the immunogenicity of allergic diseases. Protease-activated receptor (PAR)-2, Toll-like receptor (TLR), and C-type lectin receptors have been suggested to be important for the penetration of cockroach allergens through epithelial cells to mediate allergen uptake, dendritic cell maturation, antigen presenting cell (APC) function in T cell polarization, and cytokine production. Environmental pollutants, which often co-exist with the allergen, could synergistically elicit allergic inflammation, and aryl hydrocarbon receptor (AhR) activation and signaling may serve as a link between these two elements. Genetic factors may also play an important role in conferring the susceptibility to cockroach sensitization. Several genes have been associated with cockroach sensitization and asthma-related phenotypes. In this review, we will discuss the epidemiological evidence for cockroach allergen-induced asthma, cockroach allergens, the mechanisms regarding cockroach allergens induced innate immune responses, and the genetic basis for cockroach sensitization.

show abstract

Section: Introductionmentioning

confidence: 99%

Cockroach allergen exposure and risk of asthma

Danh

Zhao

Gao

2016

Allergy

135

View full text Add to dashboard Cite

show abstract

“…Recombinant P. americana allergens (Per a 1 through 7, and Per a 9), expressed in E. coli , were used to evaluate correlations with clinical manifestations and severity of disease among patients from Taiwan [98]. IgE-binding to Per a 2 was more frequently found among the group of patients with persistent asthma, as compared to patients with rhinitis only (81 vs. 45 %, p < .05).…”

Section: Recombinant Cockroach Allergens For Diagnosismentioning

confidence: 99%

Recombinant Allergens for Diagnosis of Cockroach Allergy

Arruda

Barbosa

Santos

et al. 2014

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Molecular cloning of cockroach allergens and their expression as recombinant proteins have allowed a better understanding of the mechanisms of cockroach allergic disease. Recombinant cockroach allergens have been used for skin testing or in vitro methods to measure IgE antibody levels in serum. Early studies evaluating selected U.S. patients revealed that a cocktail of four cockroach allergens, Bla g 1, Bla g 2, Bla g 4, and Bla g 5, would identify 95 % of cockroach allergic patients. More recent studies pointed to an important role of sensitization to tropomyosin among certain populations, and suggested that a cocktail of five allergens Bla g 1 and/or Per a 1, Bla g 2, Bla g 4, Bla g 5, and Bla g 7, and/or Per a 7, would be expected to diagnose 50–64 % of cockroach-allergic patients worldwide. Variation in IgE reactivity profiles could be in part due to IgE responses to cross-reactive homologous allergens from different origins. The availability of purified natural or recombinant cockroach allergens provides the capacity to improve diagnosis of cockroach allergy and to develop novel forms of immunotherapy for cockroach-allergic patients.

show abstract

“…A marker for severity of disease among cockroach-allergic patients in Taiwan was IgE to Per a 2 (aspartatic protease-like), which is more frequent among the group of patients with persistent asthma [121].…”

Section: Cockroach Allergens and Asthmamentioning

confidence: 99%

Protein Biomarkers in Asthma

Karaulov

Garib

et al. 2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Asthma is a chronic disabling respiratory disease that can be triggered by a variety of factors, including allergens, respiratory infections, psychological factors, occupational agents, exercise, atmospheric pollutants, and drugs. The asthma syndrome has been treated for decades according to a “one-fits-all” treatment strategy based on bronchodilators and steroids. With the availability of new forms of treatment targeting the different pathomechanisms of the asthma syndrome, such as anti-immunoglobulin E and cytokine-targeting therapies, the interest in biomarkers that can dis criminate different forms of asthma according to their pathomechanisms has increased. This review attempts to provide an overview of protein biomarkers in asthma and how they might be used to discriminate different forms of asthma that may respond positively to sophisticated new targeted therapies.

show abstract

Sensitization to per a 2 of the American cockroach correlates with more clinical severity among airway allergic patients in Taiwan

Cited by 47 publications

References 36 publications

Cockroach allergen exposure and risk of asthma

Cockroach allergen exposure and risk of asthma

Recombinant Allergens for Diagnosis of Cockroach Allergy

Protein Biomarkers in Asthma

Contact Info

Product

Resources

About