Sensorineural deafness associated with IgA nephropathy

Abstract

IgA nephropathy is an immune complex glomerulonephritis in which examination of the renal biopsy by immu-nofluorescence reveals IgA as the predominant antibody deposited in the glomerular mesangium (Clarkson et al., 1984). It was first described by Berger in 1969. The disease is more common in males and occurs generally during the second or third decades of life (Emancipator et al., 1985). A case of established IgA nephropathy with subsequent onset of sensorineural deafness is described.

The possible association of pyoderma gangrenosum and progressive sensorineural deafness

“…Extensive vasculitis of the internal auditory artery has been found associated with ischaemic necrosis of the inner ear and fibrosis (Gussen, 1977). Other autoimmune conditions associated with sensorineural deafness include temporal arteritis (Kramer et al, 1988), Wegener's granulomatosis (Clements et al, 1989) and IgA nephropathy, an immune complex glomerulonephritis (Ataya, 1989).…”