Sensorineural Hearing Loss Associated With Ulcerative Colitis: A Case Report

A clinical study on association between hearing loss and inflammatory bowel disease in a population attending a hospital

“…16 However, Kumar BN et al reported sensorineural hearing loss and UC in a 12-year old boy which initially responded to steroid therapy, but four years later resulted in bilateral profound sensorineural hearing loss in spite of good control of his bowel disease. 3 Immediate treatment with steroids with or without immunosupressive agents is essential, as delay may lead to irreversible hearing loss. TNF-α blockade by specific antibodies, such as infliximab, may offer an additional treatment option for these patients, 23 indicating that TNF-α may play a critical role in the pathophysiology of the disease.…”

“…1 Summers and Harker described the first case of dysacusis associated with ulcerative colitis in 1982. 2,3 Sensorineural hearing loss has frequently been described in association with variety of autoimmune diseases A [3][4][5][6] though the pathophysiology of sensorineural deafness remains obscure, the autoimmune nature of the disease strengthens some proposed theories that explain its appearance and progression. 1,6 These forms of dysacusis usually presents as a subclinical condition or as severe bilateral hearing loss, such as sudden deafness 5 .There are no specific tests to establish the diagnosis of autoimmune dysacusis.…”

“…Other immunosuppressants have also been suggested by some authors. 3,5 The differential diagnosis is required for cases of sensorineural dysacusis. However, examination will not necessarily confirm a specific etiology.…”

Psoriasisli Hastalarda İşitme Kaybının Değerlendirilmesi

“…İlk olarak McCabe 1 tarafından hızlı ilerleyen progresif bilateral idiyopatik sensörinöral işitme kaybı olan bir hastada kortikosteroid tedavisi sonrası işitmenin düzelmesi üzerine etyolojide otoimmün bir patogenezin olabileceği fikri ileri sürülmüştür. Bu fikri takiben şu ana dek literatürde vitiligo, ülseratif kolit, Crohn hastalığı, Wegener granülomatozisi, romatoid artrit, dev hücreli artrit, psoriatik artrit, ankilozan spondilit gibi otoimmün hastalıklarla sensörinöral işitme kaybı birlikteliğini ortaya koyan çalışmalar bildirilmiştir 1,[11][12][13][14][15][16][17] . Öztürk ve ark.…”

Sensorineural hearing loss as an extra-intestinal manifestation of ulcerative colitis in an adolescent girl with pyoderma gangrenosum

“…Sensorineural hearing loss is a well recognised condition of variable aetiology also associated with systemic immune diseases such as rheumatoid arthritis, polyarteritis nodosa, Wegener granulomatosis and giant cell arteritis [9,10,11,13,15,16]. In 1979, McCabe described a series of 18 patients with sudden onset deafness who did not fall into the known categories of nerve deafness and proposed the new entity of auto-immune sensorineural hearing loss to explain the condition [14].…”