Sensorineural hearing loss in pseudoexfoliation

Turáçli, M. Erol; Özdemir, Filiz A.; Tekeli, Oya; Gökcan, Kürşat; Gerçeker, Muharrem; Dürük, Kudret

doi:10.3129/can.j.ophthalmol.06-087

Cited by 19 publications

(26 citation statements)

References 10 publications

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“…Within those with PXF, they also reported that the highest proportion of hearing impaired individuals had bilateral PXG. 62 In contrast, Yazdani et al (2008) reported that the presence of glaucoma did not influence the prevalence of hearing loss in individuals with PXF versus without PXF. 70 Support for similar rates of hearing loss between PXF cases with and without glaucoma has been reported in additional studies that compare results with national standard thresholds.…”

Section: Auditory Systemmentioning

confidence: 96%

“…Specifically, a body of research has centred on the higher incidence of sensorineural hearing loss in individuals with pseudoexfoliation (PXF) syndrome. [58][59][60][61][62] Individuals with PXF are predisposed to developing glaucomatous optic neuropathy (labelled pseudoexfoliative glaucoma or PXG) that is caused by an open-angle mechanism. 63 The pathogenesis of PXF is unknown but may be a diffuse basement membrane disorder or part of more widespread elastosis affecting multiple organs including the ear and eye.…”

Section: Auditory Systemmentioning

confidence: 99%

“…63 Given that the hallmark of PXF is fibrillar accumulation, it has been postulated that this extracellular material accumulates within the cochlea, impairing the function of the hair cells and degrading neuroelectrical stimulation of the vestibulocochlear nerve. 62 Alternatively, some individuals with PXF have impaired tympanometric peak values, suggesting middle ear dysfunction. 46,60 Additionally, PXF is associated with systemic vascular disease that involves fibrils in vessel walls, which could lead to abnormalities in the blood supply to peripheral sensory organs, and as a result, perpetuate sensory impairments secondary to relative ischemia.…”

Section: Auditory Systemmentioning

confidence: 99%

“…[64][65][66][67] Studies exploring PXF and hearing loss generally support a relationship, but it is not clear whether it is more common in PXF alone or in conjunction with PXF glaucoma. [58][59][60][61][62][68][69][70] In addition, there is no consensus on whether the hearing loss is generalized or specific to select octave bands. Turacli et al (2007) revealed a higher incidence of hearing loss in individuals with PXF compared with those without PXF.…”

Section: Auditory Systemmentioning

confidence: 99%

“…[58][59][60][61][62][68][69][70] In addition, there is no consensus on whether the hearing loss is generalized or specific to select octave bands. Turacli et al (2007) revealed a higher incidence of hearing loss in individuals with PXF compared with those without PXF.…”

Section: Auditory Systemmentioning

confidence: 99%

See 4 more Smart Citations

Is primary open‐angle glaucoma part of a generalized sensory neurodegeneration? A review of the evidence

O’Hare¹,

Rance²,

McKendrick³

et al. 2012

Clinical Exper Ophthalmology

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Open-angle glaucoma is an optic neuropathy that has a multifarious aetiological profile. Emerging theories suggest that a group of factors induce optic nerve injury in innately susceptible aging optic nerves. These factors have the potential to impact on the function of other vulnerable neurons within the central nervous system of older patients. Although changes within the visual pathways due to retinal ganglion cell dysfunction and death are well established, research exploring the behaviour of other sensory systems in individuals with glaucoma is limited. This review summarizes what is known about these other non-visual sensory changes, explores whether glaucoma is in fact part of a global neurodegenerative condition, and suggests areas for future research direction.

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Section: Auditory Systemmentioning

confidence: 96%

Section: Auditory Systemmentioning

confidence: 99%

Section: Auditory Systemmentioning

confidence: 99%

Section: Auditory Systemmentioning

confidence: 99%

Section: Auditory Systemmentioning

confidence: 99%

See 3 more Smart Citations

Is primary open‐angle glaucoma part of a generalized sensory neurodegeneration? A review of the evidence

O’Hare¹,

Rance²,

McKendrick³

et al. 2012

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

show abstract

Geographic and Climatic Factors Associated With Exfoliation Syndrome

et al. 2011

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Hearing Loss in Exfoliation Syndrome: Systematic Review and Meta‐Analysis

et al. 2022

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Objective: To determine if exfoliation syndrome (XFS) is associated with hearing loss (HL) or vestibular dysfunction. Data Sources: PubMed, Scopus, CINAHL, and Cochrane Library through April 1, 2022. Review Methods: Two reviewers independently screened abstracts, selected articles for inclusion, and extracted data. Studies included for qualitative analysis conducted audiometric, tympanometric, or vestibular evaluations on all subjects.Results: Twenty-one publications (1148 patients with XFS and 1212 controls) were included in the systematic review, and 16 publications (968 patients with XFS and 1147 controls) in the meta-analysis. Greater severity of HL was seen for patients with XFS compared to controls across all frequencies (odds ratio [OR] 8.8 [7.3-10.2]). Patients with XFS were more likely to have moderate to profound sensorineural HL ), and less likely to have none to mild HL (OR 0.34 [0.17-0.67]) or no HL (OR 0.37 [0.28-0.50]). Three studies found patients with XFS had lower tympanometric peaks. Two studies found that abnormal vestibular testing results could be more common for patients with XFS.Conclusions: HL is associated with XFS. A sensorineural component to HL is confirmed, and mixed HL is possible. Given the high prevalence and infrequent diagnosis of XFS, the authors hypothesize that the current understandings of presbycusis might be improved by further investigation in XFS.

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Sensorineural hearing loss in pseudoexfoliation

Cited by 19 publications

References 10 publications

Is primary open‐angle glaucoma part of a generalized sensory neurodegeneration? A review of the evidence

Is primary open‐angle glaucoma part of a generalized sensory neurodegeneration? A review of the evidence

Geographic and Climatic Factors Associated With Exfoliation Syndrome

Hearing Loss in Exfoliation Syndrome: Systematic Review and Meta‐Analysis

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