Sensory and motor responses after photobiomodulation associated with physiotherapy in patients with incomplete spinal cord injury: clinical, randomized trial

Silva, Fernanda Cordeiro da; Silva, Tamiris; Gomes, Andréa Oliver; Palácio, Paulo Roberto da Costa; Andreo, Lucas; Gonçalves, Marcela Letícia Leal; Silva, Daniela de Fátima Teixeira da; Horliana, Anna Carolina Ratto Tempestini; Motta, Lara Jansiski; Mesquita‐Ferrari, Raquel Agnelli; Fernandes, Kristianne Porta Santos; Bussadori, Sandra Kalil

doi:10.1007/s10103-020-02968-6

Cited by 16 publications

(11 citation statements)

References 17 publications

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“…To enable improvements in functional capacity and quality of life, Silva et al [ 40 ] performed physical therapy combined with PBM in patients with spinal cord injuries. The physiotherapeutic protocol consisted of stretching and muscle strengthening exercises.…”

Section: Discussionmentioning

confidence: 99%

Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study

et al. 2021

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Introduction Myelomeningocele is a severe type of spina bifida, resulting from improper closure of the neural tube. This condition drastically affects the structures of the spinal cord resulting in deficiencies. The combination of these deficiencies results in an overall decrease in mobility and functional participation amongst this population. Physiotherapy plays an essential role in rehabilitating people with MMC. The current literature shows that resources such as photobiomodulation (PBM) may support the rehabilitation of neurological conditions. The aim of the proposed study is to evaluate the effects of photobiomodulation (PBM) combined with physical therapy on functional performance in children with low lumbosacral myelomeningocele. Materials and methods This is a protocol randomized clinical blind study, that will include 30 individuals of both sexes, aged between 5 to 8 years, diagnosed with low and sacral lumbar myelomeningocele and capable of performing the sit-to-stand task. The participants will be randomly assigned into two treatment groups: PBM + physiotherapeutic exercises and sham PBM + physiotherapeutic exercises. Irradiation will be carried out with light emitting diode (LED) at a wavelength of 850 nm, energy of 25 J per point, 50 seconds per point and a power of 200 mW. The same device will be used in the placebo group but will not emit light. Muscle activity will be assessed using a portable electromyograph (BTS Engineering) and the sit-to-stand task will be performed as a measure of functioning. Electrodes will be positioned on the lateral gastrocnemius, tibialis anterior and rectus femoris muscles. The Pediatric Evaluation of Disability Inventory will be used to assess functional independence. Quality of life will be assessed using the Child Health Questionnaire—Parent Form 50. Changes in participation will be assessed using the Participation and Environment Measure for Children and Youth. The data will be analyzed with the aid of GraphPad PRISM. Discussion The results of this study can contribute to a better understanding of the effectiveness of PBM on functioning and quality of life in children with myelomeningocele. Clinical trial registration ClinicalTrials.gov Identifier: NCT04425330.

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Section: Discussionmentioning

confidence: 99%

Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study

et al. 2021

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“…Damaged nerve cells, axons, and vascular endothelial cells release harmful substances that attack adjacent tissues, leading to permanent dysfunction 23 . In addition, the SCI blocks supraspinal information to reach the peripheral muscles, leading to motor function loss, and also blocks peripheral information from reaching the brain, leading to sensory function loss 24 …”

Section: Ensc Therapy On Scimentioning

confidence: 99%

“…23 In addition, the SCI blocks supraspinal information to reach the peripheral muscles, leading to motor function loss, and also blocks peripheral information from reaching the brain, leading to sensory function loss. 24 After developing a model with minimal SCI and labeling the ependymal by injecting markers, some studies found that the proliferation marker index of ependymal cells increased significantly and most of the cells migrated within 70 microns of the central canal. These results showed that minimal SCI near the ependymal was sufficient to induce ependymal cell proliferation and migration, which was considered a promising cell source for therapeutic nerve repair.…”

Section: Ensc Therapy On Scimentioning

confidence: 99%

Research progress of endogenous neural stem cells in spinal cord injury

Wang

Yuan

2022

Ibrain

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Spinal cord injury (SCI) is a severe disabling disease, which mainly manifests as impairments of sensory and motor functions, sexual function, bladder and intestinal functions, respiratory and cardiac functions below the injury plane.In addition, the condition has a profound effect on the mental health of patients, which often results in severe sequelae. Some patients may be paraplegic for life or even die, which places a huge burden on the family and society. There is still no effective treatment for SCI. Studies have confirmed that endogenous neural stem cells (ENSCs), as multipotent neural stem cells, which are located in the ependymal region of the central canal of the adult mammalian spinal cord, are activated after SCI and then differentiate into various nerve cells to promote endogenous repair and regeneration. However, the central canal of the spinal cord is often occluded to varying degrees in adults, and residual ependymal cells cannot be activated and do not proliferate after SCI. Besides, the destruction of the microenvironment after SCI is also an important factor that affects the proliferation and differentiation of ENSCs and spinal cord repair. Therefore, this review describes the role of ENSCs in SCI, in terms of the origin, transformation, treatment, and influencing factors, to provide new ideas for clinical treatment of SCI.

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“…Spinal cord injury (SCI) is a major medical condition worldwide, often resulting in motor dysfunction and chronic pain syndromes. 1,2 Approximately one million people worldwide have been reported to suffer from SCI-related disorders each year, with traumatic contusions being the most common. 3,4 Traumatic SCI includes primary injury and secondary injury.…”

Section: Introductionmentioning

confidence: 99%

Macrophage Membrane-Coated MnO₂ Nanoparticles Provide Neuroprotection by Reducing Oxidative Stress after Spinal Cord Injury

An,

Jiang,

et al. 2023

ACS Appl. Nano Mater.

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Secondary injury following spinal cord injury (SCI) results in a large production of reactive oxygen species (ROS) (e.g., H 2 O 2 ) in the spinal cord microenvironment, which then leads to an excessive burst of inflammation and ultimately neuronal death. In this study, we prepared manganese dioxide (MnO 2 ) nanoparticles coated by macrophage membranes, named M@MnO 2 , to cope with early ROS bursts in the SCI microenvironment. The biosafety and targeting ability of the MnO 2 nanoparticles were improved through the macrophage membranes. Successful preparation of M@MnO 2 was verified by transmission electron microscopy, Western blot, and dynamic light scattering. Small animal imaging showed that M@MnO 2 accumulated in large quantities at the site of SCI. In the early stages of SCI, M@MnO 2 effectively reduced the ROS content, as well as the hypoxia-inducible factor 1α (HIF-1α) content, malondialdehyde content, and superoxide anion content caused by ROS, further leading to a decrease in some of the proteins associated with inflammation at the site of SCI (CD11b, CD86, COX2, IL-1β, and iNOS), ultimately achieving neuroprotection and recovery of motor function.

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Sensory and motor responses after photobiomodulation associated with physiotherapy in patients with incomplete spinal cord injury: clinical, randomized trial

Cited by 16 publications

References 17 publications

Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study

Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study

Research progress of endogenous neural stem cells in spinal cord injury

Macrophage Membrane-Coated MnO₂ Nanoparticles Provide Neuroprotection by Reducing Oxidative Stress after Spinal Cord Injury

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Sensory and motor responses after photobiomodulation associated with physiotherapy in patients with incomplete spinal cord injury: clinical, randomized trial

Cited by 16 publications

References 17 publications

Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study

Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study

Research progress of endogenous neural stem cells in spinal cord injury

Macrophage Membrane-Coated MnO2 Nanoparticles Provide Neuroprotection by Reducing Oxidative Stress after Spinal Cord Injury

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Macrophage Membrane-Coated MnO₂ Nanoparticles Provide Neuroprotection by Reducing Oxidative Stress after Spinal Cord Injury