Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation

Gogolla, Nadine; Takesian, Anne E.; Feng, Guoping; Fagiolini, Michela; Hensch, Takao K.

doi:10.1016/j.neuron.2014.06.033

Cited by 285 publications

(290 citation statements)

References 72 publications

(90 reference statements)

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“…Notably, many mental illnesses that include language impairment-such as schizophrenia and autism-are of neurodevelopmental origin and share defects in the triggers and brakes that normally regulate CP timing (Gogolla et al 2009, Insel 2010, Rubenstein & Merzenich 2003. Interventions to restore CP mistiming are starting to yield promising therapeutic strategies in animal models (Gogolla et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Critical Periods in Speech Perception: New Directions

Werker

Hensch

2015

Annu. Rev. Psychol.

616

356

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A continuing debate in language acquisition research is whether there are critical periods (CPs) in development during which the system is most responsive to environmental input. Recent advances in neurobiology provide a mechanistic explanation of CPs, with the balance between excitatory and inhibitory processes establishing the onset and molecular brakes establishing the offset of windows of plasticity. In this article, we review the literature on human speech perception development within the context of this CP model, highlighting research that reveals the interplay of maturational and experiential influences at key junctures in development and presenting paradigmatic examples testing CP models in human subjects. We conclude with a discussion of how a mechanistic understanding of CP processes changes the nature of the debate: The question no longer is, "Are there CPs?" but rather what processes open them, keep them open, close them, and allow them to be reopened.

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Section: Discussionmentioning

confidence: 99%

Critical Periods in Speech Perception: New Directions

Werker

Hensch

2015

Annu. Rev. Psychol.

616

356

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“…The VENs have wider axons, which can facilitate rapid relay of signals from the AIC and ACC to other cortical regions [63], endowing the salience network with distinct mechanisms for signaling within and across the network. This network, together with interconnected brain networks, contributes to a variety of complex brain functions, including communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive information [64][65][66]. ACC activation has been commonly reported in studies of early-stage romantic love [8,21] [71].…”

Section: Discussionmentioning

confidence: 99%

Brainstem Activity Predicts Attachment-Related Anxiety

Kikuchi¹,

Matsutani²,

Mori³

et al. 2018

Neuropsychiatry

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Objective: Attachment security serves as a critical resource for individuals to preserve relationship quality. However, insecure attachment interrupts it and seriously influences mental/physical health. Therefore, it is important to clarify the correlations between brain activity and attachment-related anxiety and its avoidance. Methods:We investigated these correlations in healthy male subjects by using functional magnetic resonance imaging (fMRI) while they were viewing their partner.Results: The brain regions that were significantly activated for the partner vs. unknown females were the anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), dorsal raphe nucleus (DRN), pontine raphe nucleus (PRN), and locus coeruleus (LC) in a whole-brain analysis. A region of interest (ROI) analysis showed that the DRN, periaqueductal grey (PAG), hypothalamus, anterior insula (AIC), substantia nigra/ventral tegmental area (SN/VTA), ACC, PCC and intraparietal sulcus (IPS) were significantly activated. Furthermore, activity in the DRN, SN/VTA, and LC negatively correlated with attachment-related anxiety.Conclusions: There were individual differences in the correlations between the brainstem activity and attachment-related anxiety, although brain activity in our subjects was more similar to that observed in long-term intense romantic love and maternal love compared to that in early-stage romantic love. These brainstem regions are the primary sites of neurotransmitters which modulate basic functions of survival, and also play key roles for maintenance of secure relationships with a partner. This finding might be useful to assessment of the risk of breakdowns by factors of the attachment style.

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“…Thus, the presence of early and abundant astrocyte-regulated extracellular signals in NDDs could not only promote early maturation of PV interneurons, but also close the window of plasticity before experience-dependent circuits are properly formed. Indeed, altered PNNs have been recently reported in several autism spectrum disorder (ASD) mouse models (77). In light of this, we propose that astrocyte Ras activity, SNAI2 expression, or extracellular matrix components are possible therapeutic targets for social and neurocognitive developmental disorders.…”

Section: Discussionmentioning

confidence: 99%

Dysregulation of astrocyte extracellular signaling in Costello syndrome

et al. 2015

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Astrocytes produce an assortment of signals that promote neuronal maturation according to a precise developmental timeline. Is this orchestrated timing and signaling altered in human neurodevelopmental disorders? To address this question, the astroglial lineage was investigated in two model systems of a developmental disorder with intellectual disability caused by mutant Harvey rat sarcoma viral oncogene homolog (HRAS) termed Costello syndrome: mutant HRAS human induced pluripotent stem cells (iPSCs) and transgenic mice. Human iPSCs derived from patients with Costello syndrome differentiated to astroglia more rapidly in vitro than those derived from wild-type cell lines with normal HRAS, exhibited hyperplasia, and also generated an abundance of extracellular matrix remodeling factors and proteoglycans. Acute treatment with a farnesyl transferase inhibitor and knockdown of the transcription factor SNAI2 reduced expression of several proteoglycans in Costello syndrome iPSC-derived astrocytes. Similarly, mice in which mutant HRAS was expressed selectively in astrocytes exhibited experience-independent increased accumulation of perineuronal net proteoglycans in cortex, as well as increased parvalbumin expression in interneurons, when compared to wild-type mice. Our data indicate that astrocytes expressing mutant HRAS dysregulate cortical maturation during development as shown by abnormal extracellular matrix remodeling and implicate excessive astrocyte-to-neuron signaling as a possible drug target for treating mental impairment and enhancing neuroplasticity.

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Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation

Cited by 285 publications

References 72 publications

Critical Periods in Speech Perception: New Directions

Critical Periods in Speech Perception: New Directions

Brainstem Activity Predicts Attachment-Related Anxiety

Dysregulation of astrocyte extracellular signaling in Costello syndrome

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