Sensory mapping of lip representation in brass musicians with embouchure dystonia

Hirata, Yoshihiro; Schulz, Matthias; Altenmüller, Eckart; Elbert, Thomas; Pantev, Christo

doi:10.1097/00001756-200404090-00015

Cited by 67 publications

(41 citation statements)

References 22 publications

(22 reference statements)

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“…The most consistent finding in studies using MEG in patients with WC and/or FHD is a disordered cortical representation of digits on the somatosensory cortex (Braun et al, 2003;Byl et al, 2002;Candia et al, 2003;McKenzie et al, 2003;Meunier et al, 2001). The total surface representing the hand and different digits on the somatosensory cortex is decreased in some studies (Braun et al, 2003;Byl et al, 2002;Hirata et al, 2004) and increased in others (Braun et al, 2003;Candia et al, 2003;McKenzie et al, 2003). One study found similar results for patients with embouchure dystonia (task-specific dystonia of the mouth and jaw in musicians), namely altered lip and digit representation on the somatosensory cortex and a decreased cortical distance between hand and lip representations (Hirata et al, 2004).…”

Section: Magnetoencephalography and Electroencephalographymentioning

confidence: 75%

Structural, functional and molecular imaging of the brain in primary focal dystonia—A review

et al. 2011

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Section: Magnetoencephalography and Electroencephalographymentioning

confidence: 75%

Structural, functional and molecular imaging of the brain in primary focal dystonia—A review

et al. 2011

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“…BTX has been hypothesized to exert additional therapeutic effects by indirectly altering motor afferent feedback to the brain and thereby altering brain activity [7,8]. Empirical evidence for this has been shown in a study in which cortical (gray matter) functional mapping abnormalities known to exist in focal dystonias [9,10] reversed during BTX treatment [11]. In the present study, we sought to determine whether BTX exerts beneficial effects in subcortical motor circuitry, and whether such effects manifest in the white matter of this circuitry.…”

mentioning

confidence: 99%

White matter abnormalities in dystonia normalize after botulinum toxin treatment

Blood

Tuch²,

Makris³

et al. 2006

NeuroReport

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The pathophysiology of dystonia is still poorly understood. We used diffusion tensor imaging to screen for white matter abnormalities in regions between the basal ganglia and the thalamus in cervical and hand dystonia patients. All patients exhibited an abnormal hemispheric asymmetry in a focal region between the pallidum and the thalamus. This asymmetry was absent 4 weeks after the same patients were treated with intramuscular botulinum toxin injections. These findings represent a new systems-level abnormality in dystonia, which may lead to new insights about the pathophysiology of movement disorders. More generally, these findings demonstrate central nervous system changes following peripheral reductions in muscle activity. This raises the possibility that we have observed activity-dependent white matter plasticity in the adult human brain.

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“…This confirms the effectivity of the stimulus being used. Our approach is of relevance not for the study of brain functions in normal volunteers and also for the study of functional changes in the brain of, say the fingers and the lips in such neurological pathologies like focal hand and lips dystonia for which distortions of cortical representation have been associated with the sensorimotor disorder, and restoration of dysfunctional cortical representation with illness amelioration [1,2,9]. Further potential uses are the assessment of cortical functionality after reconstruction surgery of the hand, but also the assessment of function recovery after stroke.…”

mentioning

confidence: 99%

A portable and low-cost fMRI compatible pneumatic system for the investigation of the somatosensensory system in clinical and research environments

Wienbruch

Candia

Svensson

et al. 2006

Neuroscience Letters

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There still is a need for devices that allow reproducible stimulation of skin areas of the human body. We constructed a stimulation system and tested it by using brief pneumatic stimulation to the right thumb of nine healthy volunteers. BOLD-signals in response to tactile stimulation with frequencies of 1, 3 and 5 Hz were measured using a 3 T MRI scanner. The stimulation device consists of synthetic membranes connected to plastic tubes capable of carrying compressed air, and an electronic component, which controls the on-and off-switching of an electromagnetic valve. The valve near the MR-scanner did not lower the image quality. Primary somatosensory activation contralateral to the stimulation site was reliably detected in response to a stimulus magnitude of 3.5 bar in all volunteers. 1 Hz stimulation resulted in higher maximal percentage BOLD-signal changes. Our device is an easy-to-construct, low-cost and portable tool suitable for research and clinical environments. It permits passive non-painful stimulation relevant for clinical assessments and is also compatible with magnetoencephalography (MEG) and electroencephalography (EEG). In basic and clinical research, this device therefore contributes to meaningful comparisons between results obtained with different techniques.

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Sensory mapping of lip representation in brass musicians with embouchure dystonia

Cited by 67 publications

References 22 publications

Structural, functional and molecular imaging of the brain in primary focal dystonia—A review

Structural, functional and molecular imaging of the brain in primary focal dystonia—A review

White matter abnormalities in dystonia normalize after botulinum toxin treatment

A portable and low-cost fMRI compatible pneumatic system for the investigation of the somatosensensory system in clinical and research environments

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