Sensory neurotization of muscle: past, present and future considerations

Kozusko, Steven D.; Kaminsky, Alexander J.; Boyd, Louisa; Konofaos, Petros

doi:10.1080/2000656x.2018.1523180

Cited by 5 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The phenomenon of sensory cross‐innervation has led to its clinical application in “sensory protection” of denervated muscle 3 . Skeletal muscle will atrophy within 3 weeks of denervation, which progresses to irreversible fibrosis by 2 years if not promptly reinnervated 1 .…”

Section: Methodsmentioning

confidence: 99%

“…The phenomenon of sensory cross-innervation has led to its clinical application in "sensory protection" of denervated muscle. 3 Skeletal muscle will atrophy within 3 weeks of denervation, which progresses to irreversible fibrosis by 2 years if not promptly reinnervated. 1 Due to progressive fibrosis, collagenization of the distal nerve stump, and motor endplate loss, prolonged denervation leads to both decreased reinnervation potential and poor functional recovery after nerve repair.…”

Section: Sensory Neurotization Of Denervated Musclementioning

confidence: 99%

“…This temporary sensory protection may prevent atrophy until definitive motor reinnervation is achieved via nerve graft, nerve transfer, or ETE nerve repair. 3,4 Sensory protection has shown promising results. Although a few animal studies demonstrated limited success of muscle preservation with sensory protection, 65,66 most have shown that, compared with denervated control muscle, sensory protection resulted in preservation of muscle structure and mass, 58,59,[67][68][69][70][71][72][73][74][75] as well as improved functional recovery of denervated skeletal muscle, after definitive motor reinnervation.…”

Section: Sensory Neurotization Of Denervated Musclementioning

confidence: 99%

“…Another clinical application involves the transfer of a local sensory nerve to denervated skeletal muscle ("sensory babysitting"), which prevents muscle atrophy and preserves functional potential until motor reinnervation can occur. 3,4 In this study we address the anatomy and physiology of normal sensory innervation of muscle and the process of sensory reinnervation of muscle after peripheral nerve injury and repair, and we review the potential clinical implications of these phenomenon. It is critical to have a comprehensive understanding of the process of sensory nerve regeneration and muscle reinnervation in optimizing rehabilitation after peripheral nerve injury, neuroma treatment, development of prosthetic peripheral nerve interfaces, and sensory protection of muscle.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, sensory afferent reinnervation of muscle is a fundamental component of rehabilitation after peripheral nerve injury. Another clinical application involves the transfer of a local sensory nerve to denervated skeletal muscle (“sensory babysitting”), which prevents muscle atrophy and preserves functional potential until motor reinnervation can occur 3,4 …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Sensory nerve regeneration and reinnervation in muscle following peripheral nerve injury

et al. 2022

View full text Add to dashboard Cite

Sensory afferent fibers are an important component of motor nerves and compose the majority of axons in many nerves traditionally thought of as “pure” motor nerves. These sensory afferent fibers innervate special sensory end organs in muscle, including muscle spindles that respond to changes in muscle length and Golgi tendons that detect muscle tension. Both play a major role in proprioception, sensorimotor extremity control feedback, and force regulation. After peripheral nerve injury, there is histological and electrophysiological evidence that sensory afferents can reinnervate muscle, including muscle that was not the nerve's original target. Reinnervation can occur after different nerve injury and muscle models, including muscle graft, crush, and transection injuries, and occurs in a nonspecific manner, allowing for cross‐innervation to occur. Evidence of cross‐innervation includes the following: muscle spindle and Golgi tendon afferent‐receptor mismatch, vagal sensory fiber reinnervation of muscle, and cutaneous afferent reinnervation of muscle spindle or Golgi tendons. There are several notable clinical applications of sensory reinnervation and cross‐reinnervation of muscle, including restoration of optimal motor control after peripheral nerve repair, flap sensation, sensory protection of denervated muscle, neuroma treatment and prevention, and facilitation of prosthetic sensorimotor control. This review focuses on sensory nerve regeneration and reinnervation in muscle, and the clinical applications of this phenomena. Understanding the physiology and limitations of sensory nerve regeneration and reinnervation in muscle may ultimately facilitate improvement of its clinical applications.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Sensory Neurotization Of Denervated Musclementioning

confidence: 99%

Section: Sensory Neurotization Of Denervated Musclementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sensory nerve regeneration and reinnervation in muscle following peripheral nerve injury

et al. 2022

View full text Add to dashboard Cite

show abstract

Pelvic Floor and Sphincter Neuropathy After Childbirth

O’Brien

2024

Pelvic Floor, Perineal, and Anal Sphincter Trauma During Childbirth

View full text Add to dashboard Cite

Regenerative Peripheral Nerve Interfaces for the Management of Symptomatic Hand and Digital Neuromas

Hooper

Cederna

Brown

et al. 2020

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

Summary: Painful neuromas result from traumatic injuries of the hand and digits and cause substantial physical disability, psychological distress, and decreased quality of life among affected patients. The regenerative peripheral nerve interface (RPNI) is a novel surgical technique that involves implanting the divided end of a peripheral nerve into a free muscle graft for the purposes of mitigating neuroma formation and facilitating prosthetic limb control. The RPNI is effective in treating and preventing neuroma pain in major extremity amputations. The purpose of this study was to determine if RPNIs can be used to effectively treat neuroma pain following partial hand and digital amputations. We retrospectively reviewed the use of RPNI to treat symptomatic hand and digital neuromas at our institutions. Between November 2014 and July 2019, we performed 30 therapeutic RPNIs on 14 symptomatic neuroma patients. The average patient follow-up was 37 weeks (6–128 weeks); 85% of patients were pain-free or considerably improved at the last office visit. The RPNI can serve as a safe and effective surgical solution to treat symptomatic neuromas after hand trauma.

show abstract

Sensory neurotization of muscle: past, present and future considerations

Cited by 5 publications

References 32 publications

Sensory nerve regeneration and reinnervation in muscle following peripheral nerve injury

Sensory nerve regeneration and reinnervation in muscle following peripheral nerve injury

Pelvic Floor and Sphincter Neuropathy After Childbirth

Regenerative Peripheral Nerve Interfaces for the Management of Symptomatic Hand and Digital Neuromas

Contact Info

Product

Resources

About