Sentinel lymph node biopsy and breast cancer

Noguchi, Masakuni

doi:10.1046/j.0007-1323.2001.01962.x

Cited by 68 publications

(24 citation statements)

References 111 publications

(209 reference statements)

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“…4,9,10 Some of these techniques increase the laboratory workload at the time of frozen section quite dramatically, but sensitivities (in reports with more than 100 patients) have been as high as 93%. 4 Recently, Krogerus compared two frozen section Frozen section of sentinel nodes ML Mitchell techniques.…”

Section: Discussionmentioning

confidence: 99%

Frozen section diagnosis for axillary sentinel lymph nodes: the first six years

Mitchell

2005

Modern Pathology

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Intraoperative frozen section of axillary lymph nodes for the detection of metastatic breast cancer has been controversial because of the labor-intensive techniques necessary to obtain a highly sensitive test, and because of the uncertain significance of frequently detected submicrometastatic carcinoma. In total, 874 consecutive axillary sentinel lymph node cases examined by intraoperative frozen section over a 6-year period were reviewed retrospectively. Frozen section had a sensitivity of 60% and was 100% specific, but when cases with submicrometastatic tumor cells were considered negative, the sensitivity rose to 83%. Rare cases were called 'atypical' on frozen section; almost all of these cases were negative for carcinoma on permanent sections.

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Section: Discussionmentioning

confidence: 99%

Frozen section diagnosis for axillary sentinel lymph nodes: the first six years

Mitchell

2005

Modern Pathology

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“…Micrometastases were found only in the non-BN nodes in cases 2, 3, 6, and 9, but they were all within the stained lymphatic channels Various methods of exploring for micrometastases are available, including immunohistochemical staining for CKs (detection rate, 8% to 36%) [9,13,14,[17][18][19], and reverse transcription-polymerase chain reaction (RT-PCR) using carcinoembryonic antigen (CEA) mRNA (detection rate, 30% to 61%) [20][21][22]. The immunostaining method is still superior in terms of convenience, and increasing the number of sections used for routine staining and immunostaining has been found to increase the detection rate.…”

Section: Discussionmentioning

confidence: 99%

Assessment of lymph node micrometastasis in early gastric cancer in relation to sentinel nodes

2006

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“…6 Although straightforward to define, the impact of lymph node micrometastases on survival remains an unresolved issue. [7][8][9][10] In initial series, women with micrometastases did not experience a survival disadvantage when compared with women with lymph node-negative breast cancer, 1,11,12 suggesting that micrometastases are not of major clinical interest.…”

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confidence: 99%

Significance of micrometastases on the survival of women with T1 breast cancer

Maibenco

Dombi

Kau

et al. 2006

Cancer

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BACKGROUND The most important factor in predicting survival among women with newly diagnosed breast cancer is the status of the axillary lymph nodes. Although straightforward to define, the impact of micrometastases on survival remains to be completely determined. METHODS A review of data from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute was performed using 43,921 cases diagnosed from January 1988 through December 2001. Among women with invasive breast carcinomas ≤2 cm undergoing a resection of the primary malignancy and an axillary lymph node dissection, there were 42,197 cases without lymph node metastases and 1724 cases with micrometastases. Survival differences among these 2 groups were evaluated and are reported here. RESULTS Survival at 12 years was modestly affected by the presence of either solitary (5.0%) or multiple lymph nodes (3.6%) with micrometastases when compared with lymph node‐negative cases. In subgroup analyses, the decreased survival associated with micrometastases was inconsistent. The most significant survival disadvantage associated with micrometastases was found in cases with Grade 3 carcinomas. CONCLUSIONS The modest and variable impact of micrometastases on long‐term survival indicates that micrometastases are an important, but not a dominant, prognostic indicator. Cancer 2006. © 2006 American Cancer Society.

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Sentinel lymph node biopsy and breast cancer

Cited by 68 publications

References 111 publications

Frozen section diagnosis for axillary sentinel lymph nodes: the first six years

Frozen section diagnosis for axillary sentinel lymph nodes: the first six years

Assessment of lymph node micrometastasis in early gastric cancer in relation to sentinel nodes

Significance of micrometastases on the survival of women with T1 breast cancer

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