Sentinel lymph node status as an indicator of the presence of metastatic melanoma in regional lymph nodes

Thompson, John F.; McCarthy, W. H.; Bosch, C M; O’Brien, Christopher J.; Quinn, Michael J.; Paramaesvaran, S; Crotty, Kerry A.; McCarthy, Stanley W.; Uren, Roger F.; Howman-Giles, R

doi:10.1097/00008390-199508000-00008

Cited by 425 publications

(197 citation statements)

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“…Sentinel lymph nodes free of tumor have a high degree of accuracy in predicting a negative regional lymph node basin. [55][56][57][58][59] SLNB may have a role in staging the clinically negative neck in patients with SCCOT. A recent international conference on SLNB in mucosal head and neck carcinoma, including all head and neck subsites, combined results from 22 centers.…”

Section: Discussionmentioning

confidence: 99%

Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma

Greenberg

Naggar

et al. 2003

Cancer

166

116

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At present, storage capacities of single tank and tank farm have been greatly increasing. This change poses a real challenge for the applicability of current design standards. This article focuses on the applicability of safety spacing between tanks, which is one of the most important parameters of tank farm safety design. Taking PHAST and FDS as main research tools, the consequences of representative accidental scenarios were evaluated for different sizes of oil tanks to study the safety performance change caused by the increase of capability. The research results show that, when current standards are used to design the safety spacing between tanks, the safety performance increases as the capability increases. Considering the high property density, it is suggested that a higher safety performance objective has to be chosen when designing the safety spacing for ultra‐large oil tanks. © 2012 American Institute of Chemical Engineers Process Saf Prog, 2012.

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Section: Discussionmentioning

confidence: 99%

Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma

Greenberg

Naggar

et al. 2003

Cancer

166

116

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“…In this context, the surgical management strategies of the RLN have undergone considerable change in the past; with lymphatic mapping and sentinel lymph node (SLN) identification being the most relevant contribution (Cabanas, 1977;Wong et al, 1991;Morton et al, 1992). On the basis of the concept that the regional lymphatics serve as a barrier, temporarily trapping the orderly tumour spread from the primary site to more distant locations, it was proposed that the histopathological status of the SLN would accurately predict melanoma metastases (Reintgen et al, 1994;Thompson et al, 1995). Today, SNB is the most important staging tool, because the status of the SLN represents the most important prognostic factor for recurrence and survival for melanoma patients and identifies patients who might benefit from further therapy, such as completion lymph node dissection (CLND) and adjuvant interferon therapy (Morton et al, 1999;Balch et al, 2001;Hafner et al, 2004;Eggermont et al, 2007).…”

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confidence: 99%

The influence of sentinel lymph node tumour burden on additional lymph node involvement and disease-free survival in cutaneous melanoma – a retrospective analysis of 392 cases

et al. 2008

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Twenty per cent of sentinel lymph node (SLN)-positive melanoma patients have positive non-SLN lymph nodes in completion lymph node dissection (CLND). We investigated SLN tumour load, non-sentinel positivity and disease-free survival (DFS) to assess whether certain patients could be spared CLND. Sentinel lymph node biopsy was performed on 392 patients between 1999 and 2005. Median observation period was 38.8 months. Sentinel lymph node tumour load did not predict non-SLN positivity: 30.8% of patients with SLN macrometastases (X2 mm) and 16.4% with micrometastases (p2 mm) had non-SLN positivity (P ¼ 0.09). Tumour recurrences after positive SLNs were more than twice as frequent for SLN macrometastases (51.3%) than for micrometastases (24.6%) (P ¼ 0.005). For patients with SLN micrometastases, the DFS analysis was worse (P ¼ 0.003) when comparing those with positive non-SLNs (60% recurrences) to those without (17.6% recurrences). This difference did not translate into significant differences in DFS: patients with SLN micrometastasis, either with (P ¼ 0.022) or without additional positive non-SLNs (Po0.0001), fared worse than patients with tumour-free SLNs. The 2-mm cutoff for SLN tumour load accurately predicts differences in DFS. Non-SLN positivity in CLND, however, cannot be predicted. Therefore, contrary to other studies, no recommendations concerning discontinuation of CLND based on SLN tumour load can be deduced.

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“…Several studies have demonstrated that histological analysis of sentinel lymph node reflects the state of the corresponding lymph node basin 2,3,10 . In a lymphadenectomy, the anatomo-pathological study of lymph node metastases usually examines a slice 5 mm thick on each dissected lymph node.…”

Section: Discussionmentioning

confidence: 99%

“…The technique was described in 1992, and indicates the first lymph node that can receive metastatic cells from the primary tumor 1 . Many studies have demonstrated that histological analysis of sentinel node reflects the state of the corresponding lymphatic basin 2,3 . With the use of patent blue associated with nuclear medicine, the percentage of detection of lymph nodes increased up to over 97% and the percentage of detection of micrometastases increased considerably 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node biopsy in rats. Comparison between paraffin and frozen section analysis

et al. 2014

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PURPOSE:To simulate a lymph node metastasis in an animal model using activated carbon, assess their identification in frozen section analysis and compare with histopathological examination in paraffin. METHODS:Thirty two adult female rats were used. They received the carbon injection on its hind legs. Half of the rats was sacrificed on day one, and the other half after 21 days. Thus, 64 lymph nodes were dissected and split longitudinally. One half of the lymph node was sent immediately to frozen section analysis. The other half was fixed in 10% formaldehyde to be cut in paraffin. Slides were divided into quadrants and classified by the presence of carbon in these four quadrants_ They were also classified by the carbon staining intensity. RESULTS:Comparing the slides obtained in the first day and 21 days, there was a tendency of carbon to spread over time, but without statistical significance. The intensity did not alter over time. CONCLUSION:There was no concordance between the two methods of pathological analysis, however the actived carbon was seen in all lymph nodes.

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Sentinel lymph node status as an indicator of the presence of metastatic melanoma in regional lymph nodes

Cited by 425 publications

References 0 publications

Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma

Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma

The influence of sentinel lymph node tumour burden on additional lymph node involvement and disease-free survival in cutaneous melanoma – a retrospective analysis of 392 cases

Sentinel lymph node biopsy in rats. Comparison between paraffin and frozen section analysis

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