SEOM guidelines for cervical cancer

Abstract

Cervical cancer (CC) is the second most common cancer worldwide, strongly linked to high-risk human papilloma virus infection. Although screening programs have led to a relevant reduction in the incidence and mortality due to CC in developed countries, it is still an important cause of mortality in undeveloped countries. Clinical stage is still the most relevant prognostic factor. In early stages, the primary treatment is surgery or radiotherapy, whereas concomitant chemo-radiotherapy is the conventional approach in locally advanced stages. In the setting of recurrent or metastatic CC, for the first time ever, the combination of chemotherapy plus bevacizumab prolongs the overall survival beyond 12 months. Therefore, this regimen is considered by most of the oncologist a new standard of care for metastatic/recurrent CC.

APOBEC-mediated genomic alterations link immunity and viral infection during human papillomavirus-driven cervical carcinogenesis

“…Almost all cases of cervical cancer are caused by persistent infection with certain carcinogenic human papillomavirus (HPV) genotypes (4). HPVs are a large and diverse group of viruses, with new types continually being identified (5,6). There are at least 15 genotypes of carcinogenic HPV, and the two most prevalent and carcinogenic types are HPV types 16 and 18 (7).…”

Ovarian function following targeted anti-angiogenic therapy with bevacizumab

“…Bevacizumab, a monoclonal antibody that targets vascular endothelial growth factor (VEGF), is expected to become the first targeted agent to be approved for the treatment of a wide array of malignancies, including breast, ovarian, lung, colorectal and cervical cancer (4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Targeted therapies are considered to obtain a good antitumor response, without causing any major damage to healthy angiogenic tissues.…”

Immune and Anti-oxidant Functions of Ethanol Extracts of Scutellaria baicalensis Georgi in Mice Bearing U14 Cervical Cancers

“…Cervical cancer which is mainly infected by high risk human papilloma virus (HR-HPV, HPV16 and HPV 18 were the commonest genotypes) is one of the most common cancer affecting women worldwide (Bosch et al, it is the leading cause of cancer-related death, moreover, cervical cancer affects individuals at a younger age than other cancers do; almost 50% of cases are detected before the age of 35 (Oaknin et al, 2012). Therefore, it will have important significance to prevent the occurrence of cervical cancer in the early lesions.…”