Separable Anti‐Hut Which is Specific for Class II of the Miltenberger Complex 1

Section: Hutmentioning

confidence: 99%

Serological Activity of Low Frequency Antigens of the MNSs System and Reappraisal of the Miltenberger Complex

Giles¹

1982

“…Similar studies [19, 201, with neuraminidase, which removes sialic acid alone, have shown some determinants to be sensitive and others not. Mg is not dependent on sialic acid [20] whereas M is [31]. This type ofevaluation, providing complete desialisation is achieved, would yield more serological data of interest.…”

mentioning

confidence: 99%

Serological Activity of Low Frequency Antigens of the MNSs System and Reappraisal of the Miltenberger Complex

Giles¹

1982

“…Cleghorn [8] originally defined some cross-reactive antibodies like anti-Mia and anti-Hut (now denoted as anti-Hut+Mur [11,20]. The subsequent serological work has focussed on finding 'more specific' antibodies.…”

Section: Hypothetical Structures Of the MI Iv And Mi Ix Variantsmentioning

confidence: 99%

Miltenberger Subsystem of the MNSs Blood Group System

Dahr¹

1992

The Miltenberger (Mi) classes represent a group of phenotypes for red cells that carry low frequency antigens associated with the MNSs blood group system. The antigens of this system are known to be located on two sialogly- coproteins denoted as glycophorin A (GP A) and GP B. The structural alterations of seven (classes I, II, III, V, VI, VII, Vili) Mi variants and a related variant (J. L.) have been elucidated. Based on these data and yet incomplete studies of the Mi antigens, the approximate structural alterations in class IV and IX may be predicted. In addition, knowledge of the various structures and partial characterization of the Mi antigens allows one to propose detailed hypotheses concerning the epitopes recognized by the various antibodies that define the Mi subsystem. The understanding of the Mi subsystem at the molecular level paves the way for future studies aimed at a more detailed elucidation of epitopes of Mi-related antibodies, the characterization of novel Mi variants and a search for hypothetical, hitherto unknown Mi-related antibodies.