Separation and Characterization of Isomers of p-Nonylphenols by Capillary GC/GC--MS/GC--FTIR Techniques

Bhatt, B.D.; Prasad, J. S.; Kalpana, G.; Ali, Salmann

doi:10.1093/chromsci/30.6.203

Cited by 61 publications

(39 citation statements)

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“…Industrial p-nonylphenol is produced by alkylation using propene trimer. Thus, the product is a mixture of isomeric p-nonylphenols [161,162]. The technical product is composed of 22 isomers of p-nonylphenols, all of which have a branched portion at the α-position from the aromatic ring, and the most abundant types of the compound are α,α-dimethyl-heptyl-derivative isomers (= 10 isomers are included, group 1) (48.6 %).…”

confidence: 99%

Endocrine disruptors in the environment (IUPAC Technical Report)

Lintelmann

Katayama

Kurihara

et al. 2003

Pure and Applied Chemistry

334

122

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Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgment Endocrine disruptors in the environment (IUPAC Technical Report)Abstract: Many chemical substances of natural or anthropogenic origin are suspected or known to be endocrine disruptors, which can influence the endocrine system of life. This observation has led to increased interest on the part of the public and the media, as well as to a steep rise of research activities in the scientific community. New papers and results are presented so fast that it is impossible to give a complete review of this emerging research field. Therefore, this paper tries to give insight into some topics of the great scope of endocrine disruptors in the environment. To get a general idea of the biochemical and biological background, some parts of the endocrine systems of mammalians and nonmammalians are explained. The sections that follow describe important mechanisms of endocrine disruption such as interactions with hormone receptors. Test strategies for anthropogenic chemicals on various organisms are critically reviewed with respect to their problems and gaps concerning endocrine disruptors. The main emphasis of the paper is on the chemical substances suspected or known to be endocrine disruptors. To get a better comprehension of their behavior in the environment, physicochemical data such as water solubility or K ow , as well as information about their use and/or function are reviewed and compared. The main routes of exposure for most chemicals are shortly described, and data about concentrations in the environment (soil/sediment, water) are detailed.

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confidence: 99%

Endocrine disruptors in the environment (IUPAC Technical Report)

Lintelmann

Katayama

Kurihara

et al. 2003

Pure and Applied Chemistry

334

122

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“…Thus, the resulting NP consists of a mixture of 4-substituted mono-alkylphenols with variously branched nonyl groups. 2,3) Wheeler et al 4) identified 22 NP isomers using high-resolution mass spectrometry-gas chromatography with a 100 m capillary column. More recently, Ieda et al 5) tentatively identified 102 components in an NP mixture by comprehensive two-dimensional gas chromatography (GC × GC) combined with mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

Optical Resolution and Absolute Configuration of Branched 4-Nonylphenol Isomers and Their Estrogenic Activities

Saito

Uchiyama

Makino

et al. 2007

JOURNAL OF HEALTH SCIENCE

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To determine the effects of optical isomerism on the estrogenic activity of 4-nonylphenol (NP) isomers, four optically active NP isomers, (3R)-4-(3-ethyl-2-methylhexan-2-yl)phenol, (3S )-4-(3-ethyl-2-methylhexan-2-yl)phenol, (4R)-4-(2,4-dimethylheptan-4-yl)phenol and (4S )-4-(2,4-dimethylheptan-4-yl)phenol, were prepared and separated using chiral HPLC. Their absolute configurations were elucidated by X-ray crystallographic analysis of their bromobenzoylated derivatives. The estrogenic activities (recombinant yeast screen assay) of the optically active NPs were similar to those of the corresponding racemates.

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“…GC and HPLC are the most suitable analytical methods for these compounds [7][8][9][10]. Capillary electrophoresis (CE) is usually described as a complementary technique to HPLC.…”

Section: Introductionmentioning

confidence: 99%

Off-Line Concentration of Bisphenol A and Three Alkylphenols by SPE then On-Line Concentration and Rapid Separation by Reverse-Migration Micellar Electrokinetic Chromatography

Chu

et al. 2005

Chroma

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A method for separation of four environmentally important compounds (three alkylphenols and bisphenol A) by cyclodextrin-modified reverse-migration micellar electrokinetic chromatography (CD-RM-MEKC) has been optimized. On-line concentration, stacking using reversemigrating micelles and a water plug (SRW), was used to improve the limit of detection. Two main factors affecting the efficiency of enhancement by SRW, injection sample length and water-plug length, are discussed in detail. Compared with the normal 2-s injection, more than 121-fold enhancement of peak area and more than 71-fold enhancement of peak height were achieved with 120-s sample injection after 120-s water-plug injection. With this optimized separation method and SRW technology, limits of detection were found to be 0.089, 0.030, 0.0091, and 0.033 mg L )1 for 4-nonylphenol, 4-tert-octylphenol, bisphenol A, and 4-tertbutylphenol, respectively. Calibration plots (R 2 ‡ 0.9968) and relative standard deviations (RSD, %) of corrected peak areas and migration time were also satisfactory. Combined with offline concentration by solid-phase extraction (SPE) this method might be used to determine these contaminants at ppb levels in groundwater samples.

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Separation and Characterization of Isomers of p-Nonylphenols by Capillary GC/GC--MS/GC--FTIR Techniques

Cited by 61 publications

References 0 publications

Endocrine disruptors in the environment (IUPAC Technical Report)

Endocrine disruptors in the environment (IUPAC Technical Report)

Optical Resolution and Absolute Configuration of Branched 4-Nonylphenol Isomers and Their Estrogenic Activities

Off-Line Concentration of Bisphenol A and Three Alkylphenols by SPE then On-Line Concentration and Rapid Separation by Reverse-Migration Micellar Electrokinetic Chromatography

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