Separation and characterization of modified pregabalins in terms of cyclodextrin complexation, using capillary electrophoresis and nuclear magnetic resonance

Béni, Szabolcs; Sohajda, Tamás; Neumajer, Gábor; Iványi, Róbert; Szente, Lajos; Noszál, Béla

doi:10.1016/j.jpba.2009.10.010

Cited by 50 publications

(34 citation statements)

References 22 publications

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“…Onal and Saqirli [5] determined pregabalin in bulk and pharmaceutical preparations by spectrophotometric and spectro florometric techniques. Other methods for determination of pregambalin include ultra-high pressure liquid chromatography (UPLC) and tandem mass spectrometric (MS/MS) in whole blood and urine [6] NMR technique and capillary electrophoresis [7].…”

Section: Introductionmentioning

confidence: 99%

Monitoring of Pregabalin in Pharmaceutical Formulations and Human Serum Using UV and RP-HPLC Techniques: Application to Dissolution Test Method

M¹

2014

Pharm Anal Acta

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Section: Introductionmentioning

confidence: 99%

Monitoring of Pregabalin in Pharmaceutical Formulations and Human Serum Using UV and RP-HPLC Techniques: Application to Dissolution Test Method

M¹

2014

Pharm Anal Acta

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“…NMR spectroscopy is one of the most powerful techniques to characterize inclusion complexation at the molecular level []. To determine the complex stoichiometry, NMR titration experiments were carried out according to Job's method of continuous variation [].…”

Section: Introductionmentioning

confidence: 99%

Chiral recognition of imperanene enantiomers by various cyclodextrins: A capillary electrophoresis and NMR spectroscopy study

et al. 2012

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The enantiomers of imperanene, a novel polyphenolic compound of Imperata cylindrica (L.), were separated via cyclodextrin-modified capillary electrophoresis. The anionic form of the analyte at pH 9.0 was subject to complexation and enantioseparation CE studies with neutral and charged cyclodextrins. As chiral selectors 27 CDs were applied differing in cavity size, sidechain, degree of substitution (DS) and charge. Three hydroxypropylated and three sulfoalkylated CD preparations provided enantioseparation and the migration order was successfully interpreted in each case in terms of complex mobilities and stability constants. The best enantioresolution (R(S) = 1.26) was achieved using sulfobutyl-ether-γ-CD (DS ∼4), but it could be enhanced by extensive investigations on dual selector systems. After optimization (CD concentrations and pH) R(S) = 4.47 was achieved using a 12.5 mM sulfobutyl-ether-γ-CD and 10 mM 6-monodeoxy-6-mono-(3-hydroxy)-propylamino-β-cyclodextrin dual system. The average stoichiometry of the complex was determined with Job's method using NMR-titration and resulted in a 1:1 complex for both (2-hydroxy)propyl-β- and sulfobutyl-ether-γ-CD. Further NMR experiments suggest that the coniferyl moiety of imperanene is involved in the host-guest interaction.

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“…6‐monodeoxy‐6‐mono‐(3‐hydroxy)‐propylamino‐β‐CD hydrochloride, trimethylated α‐ and β‐CD systems resulted in the best separation. The structures of the 1:1 inclusion complexes of the tosyl‐ S ‐enantiomer with β‐CD were elucidated using 2‐D ROESY NMR experiments 88.…”

Section: Chiralitymentioning

confidence: 99%

Recent advances in amino acid analysis by capillary electrophoresis

et al. 2011

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This paper describes the most important articles that have been published on amino acid analysis using CE during the period from June 2009 to May 2011 and follows the format of the previous articles of Smith (Electrophoresis 1999, 20, 3078-3083), Prata et al. (Electrophoresis 2001, 22, 4129-4138) and Poinsot et al. (Electrophoresis 2003, 24, 4047-4062; Electrophoresis 2006, 27, 176-194; Electrophoresis 2008, 29, 207-223; Electrophoresis 2010, 31, 105-121). We present new developments in amino acid analysis with CE, which are reported describing the use of lasers or light emitting diodes for fluorescence detection, conductimetry electrochemiluminescence detectors, mass spectrometry applications, and lab-on-a-chip applications using CE. In addition, we describe articles concerning clinical studies and neurochemical applications of these techniques.

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Separation and characterization of modified pregabalins in terms of cyclodextrin complexation, using capillary electrophoresis and nuclear magnetic resonance

Cited by 50 publications

References 22 publications

Monitoring of Pregabalin in Pharmaceutical Formulations and Human Serum Using UV and RP-HPLC Techniques: Application to Dissolution Test Method

Monitoring of Pregabalin in Pharmaceutical Formulations and Human Serum Using UV and RP-HPLC Techniques: Application to Dissolution Test Method

Chiral recognition of imperanene enantiomers by various cyclodextrins: A capillary electrophoresis and NMR spectroscopy study

Recent advances in amino acid analysis by capillary electrophoresis

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