Separation of active components tyrosol and salidroside from Rhodiola rosea crude extract by two-step multistage fractionation extraction

Xu, Feng; Wang, Wanru; Liu, Fusong; Zhang, Panliang; Tang, Fengci; Zeng, Leli

doi:10.1016/j.cep.2022.108800

Cited by 7 publications

(2 citation statements)

References 42 publications

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“…In this study, Jeon and colleagues extracted 1.2 kg S. huletni with MeOH; suspended 220 g MeOH in water, partitioned with n-hexane, CHCL 3 , and n-BuOH to leave a residual water-soluble compound; evaporated each fraction; and tested the cytotoxic ability of each fraction [ 92 ]. Using n-butanol as a solvent resulted in the separation of picein with 93.6% purity [ 93 ]. Another study performed on immortalized human non-tumorigenic keratinocytes (HaCaT) also showed that the other compounds of Salix reticulata significantly inhibited cell proliferation, whereas such an effect was not observed for picein [ 94 ].…”

Section: Antioxidative and Neuroprotective Properties Of Piceinmentioning

confidence: 99%

The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature

et al. 2022

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Neurodegenerative diseases (NDDs) are the main cause of dementia in the elderly, having no cure to date, as the currently available therapies focus on symptom remission. Most NDDs will progress despite treatment and eventually result in the death of the patient after several years of a burden on both the patient and the caregivers. Therefore, it is necessary to investigate agents that tackle the disease pathogenesis and can efficiently slow down or halt disease progression, with the hope of curing the patients and preventing further burden and mortality. Accordingly, recent research has focused on disease-modifying treatments with neuroregenerative or neuroprotective effects. For this purpose, it is necessary to understand the pathogenesis of NDDs. It has been shown that oxidative stress plays an important role in the damage to the central nervous system and the progression of neurodegenerative disorders. Furthermore, mitochondrial dysfunction and the accumulation of unfolded proteins, including beta-amyloid (Aβ), tau proteins, and α-synuclein, have been suggested. Accordingly, cellular and molecular studies have investigated the efficacy of several natural compounds (herbs and nutritional agents) for their neuroprotective and antioxidative properties. The most popular herbs suggested for the treatment and/or prevention of NDDs include Withania somnifera (ashwagandha), ginseng, curcumin, resveratrol, Baccopa monnieri, and Ginkgo biloba. In some herbs, such as ginseng, preclinical and clinical evidence are available for supporting its effectiveness; however, in some others, only cellular and animal studies are available. In line with the scant literature in terms of the effectiveness of herbal compounds on NDDs, there are also other herbal agents that have been disregarded. Picein is one of the herbal agents that has been investigated in only a few studies. Picein is the active ingredient of several herbs and can be thus extracted from different types of herbs, which makes it more available. It has shown to have anti-inflammatory properties in cellular and plant studies; however, to date, only one study has suggested its neuroprotective properties. Furthermore, some cellular studies have shown no anti-inflammatory effect of picein. Therefore, a review of the available literature is required to summarize the results of studies on picein. To date, no review study seems to have addressed this issue. Thus, in the present study, we gather the available information about the antioxidative and potential neuroprotective properties of picein and its possible effectiveness in treating NDDs. We also summarize the plants from which picein can be extracted in order to guide researchers for future investigations.

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Section: Antioxidative and Neuroprotective Properties Of Piceinmentioning

confidence: 99%

The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature

et al. 2022

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“…And the equipment required for supercritical fluids is extremely expensive, limiting its application. At present, there are multi-stage extraction devices [12] on the market which are equipped with a stirring paddle in the middle, so that the liquid mixed by two phases can be quickly stratified in the stirring process. Nevertheless, the limitation of these devices is only used in liquid-liquid two-phase extraction, and the extraction of different parts of natural products must be carried out step by step.…”

Section: Introductionmentioning

confidence: 99%

Construction of coaxial liquid centrifugal platform for the extraction of active ingredients from natural products

Xiong

Chen

Duan

et al. 2023

J of Separation Science

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In the classical natural product extraction and separation process, it is tedious and requires large amounts of reagents and time. In this study, an efficient coaxial liquid centrifugal oil‐water‐oil triple‐liquid‐phase system with a simple structure and convenient operation was successfully constructed and used to extract flavonoids from Platycladi Cacumen. The results showed that the coaxial liquid centrifugal platform constructed in this study had good stability and 6 ml was the minimum volume of the middle phase for 1000 rpm to stabilize the system. Besides, it was easy to repeat the operation: the relative standard deviations of the extraction yields of flavonoids and sugar in six parallel operations were all less than 10%. Moreover, it was only one‐tenth of the time required for this method as traditional liquid‐liquid extraction while reducing the use of volatile organic reagents. Finally, the new method was more selective than the traditional method for the extraction of flavonoids. Therefore, this study provides a possibility for the coaxial liquid centrifugal platform to be used in multi‐liquid phase systems to achieve the simultaneous extraction of different parts of natural products by different liquid phases. It is expected to provide a reliable reference for further expansion of small‐scale experimental operations to industrial production.

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Evaluating the effects of surfactant types on the properties and stability of oil-in-water Rhodiola rosea nanoemulsion

Iskandar,

Mei,

Liu

et al. 2024

Colloids and Surfaces B: Biointerfaces

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Separation of active components tyrosol and salidroside from Rhodiola rosea crude extract by two-step multistage fractionation extraction

Cited by 7 publications

References 42 publications

The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature

The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature

Construction of coaxial liquid centrifugal platform for the extraction of active ingredients from natural products

Evaluating the effects of surfactant types on the properties and stability of oil-in-water Rhodiola rosea nanoemulsion

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