Separation of enantiomers by supercritical fluid extraction

Gas Antisolvent Approach for the Precipitation of α-Methoxyphenylacetic Acid – (R)-1-Cyclohexylethylamine Diateromeric Salt

“…The half equivalent method or commonly known as the modified PopePeachy method is the best suitable for the resolution, as typical in the supercritical resolution techniques. 19 The equivalent method, i.e. Pasteur's method, gives a diastereomeric salt with worse optical purity and selectivity.…”

Principles, Concepts and Strategies of Stereoselective Synthesis

“…[132][133][134][135] Supercritical fluid extraction technology recently became a versatile tool in the purification, enantioseparation, and large-scale production of enantiomers of pharmaceuticals and is gaining popularity in the pharmaceutical industry. [136][137][138] The basic idea of enantiomer resolution using supercritical fluid technology is that after the partial diastereomer formation of the racemate, only the free enantiomeric mixture is soluble in supercritical fluid, [139][140][141][142] e.g., supercritical carbon dioxide (scCO 2 ). As illustrated in the flow sheet of the resolution process (Figure 1.43), it consists of three parts: preparation of the sample, extraction, and processing the raffinate.…”

Gas antisolvent fractionation based optical resolution of ibuprofen with enantiopure phenylglycinol

“…Since the first publication of Simándi and his group, several supercritical extraction based optical resolutions have been investigated [12][13] [14]. The in situ process [15] employs carbon dioxide as the only solvent to produce optically active salts, while a two-step carbon dioxide extraction process subsequent to the melt crystallization of the diastereomers [13] is also possible.…”