Sepsis: A Review of Advances in Management

Rello, Jordi; Valenzuela-Sánchez, Francisco; Ruiz-Rodriguez, Maria; Moyano, Silvia

doi:10.1007/s12325-017-0622-8

Cited by 341 publications

(293 citation statements)

References 124 publications

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“…Higher lethality of a disseminated infection is often due to the inability to contain inflammation-induced organ and tissue damage by the host (1). There are no specific immunotherapies against disseminated infections, such as sepsis, and often management focuses on containing the infection through source control and antibiotics or antifungals plus organ function support (39). We hypothesized that using an anti-inflammatory drug in WT mice may mimic the beneficial aspect (lack of tissue damage) observed in the S100A9 -/- mutant might extend host survival from disseminated IAC.…”

Section: Resultsmentioning

confidence: 99%

S100A8/A9 modulates inflammatory collateral tissue damage during intraperitoneal origin systemic candidiasis

Shankar

Uwamahoro

Holmberg

et al. 2020

Preprint

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15Peritonitis is a leading cause of severe sepsis in surgical intensive care units, as 16 over 70% of patients diagnosed with peritonitis develop septic shock. A critical role of 17 65 non-mucosal fungal diseases among hospitalized patients in the developed world are 66Candida peritonitis, also referred to as intra-abdominal candidiasis (IAC). IAC is 67 challenging to diagnose and hence results in high mortality rates ranging from 25% -68

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Section: Resultsmentioning

confidence: 99%

S100A8/A9 modulates inflammatory collateral tissue damage during intraperitoneal origin systemic candidiasis

Shankar

Uwamahoro

Holmberg

et al. 2020

Preprint

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“…Sepsis is a serious systemic inflammatory response caused by bacterial, viral and fungal infection, and is one of the major causes of death in critical care patients (Rello et al, 2017). Data from developed countries estimate more than 30 million cases of sepsis and about 20 million cases of severe sepsis globally every year, which may result in more than 5 million deaths.…”

Section: Introductionmentioning

confidence: 99%

Integration Analysis of m6A-SNPs and eQTLs Associated With Sepsis Reveals Platelet Degranulation and Staphylococcus aureus Infection are Mediated by m6A mRNA Methylation

et al. 2020

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Sepsis is a major threat with high mortality rate for critically ill patients. Response to pathogen infection by the host immune system is a key biological process involved in the onset and development of sepsis. Heterogeneous host genome variation, especially single nucleotide polymorphisms (SNPs), has long been suggested to contribute to differences in disease progression. However, the function of SNPs located in noncoding regions remains to be elucidated. Recently, m 6 A mRNA modification levels were revealed to differ at SNPs. As m 6 A is a crucial regulator of gene expression, these SNPs might control genes by changing the m 6 A level on mRNA. To investigate the potential role of m 6 A SNPs in sepsis, we integrated m 6 A-SNP and expression quantitative trait loci (eQTLs) data. Analysis revealed 15,720 m 6 A-cis-eQTLs and 381 m 6 A-trans-eQTLs associated with sepsis. We identified 1321 genes as locations of m 6 A-cis-eQTLs. These were enriched in platelet degranulation and Staphylococcus aureus infection pathways, which are vital for the pathophysiological process of sepsis. We conclude that m 6 A modification of mRNA plays a very important role in sepsis, with m 6 A-cis-eQTLs potentially having the most effect on individual variation in sepsis progression.

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“…Thus, early diagnosis of sepsis is of utmost importance in initiating treatment in sepsis. [2][3][4][5] In sepsis, a hyper-inflammatory response is followed by an immunosuppressive phase during which multiple organ dysfunction develops which will lead to hospital acquired infections.…”

Section: Introductionmentioning

confidence: 99%

The role of neutrophil/lymphocyte ratio in predicting the severity of sepsis in a tertiary care hospital in South India: a retrospective study

George¹,

Thomas²,

Gaffoor³

2020

Int J Res Med Sci

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Background: Sepsis, a syndrome of dysregulated host response to infection leading to life-threatening organ dysfunction, is having a substantial burden in health system. The outcome in sepsis is often time dependent. None of the clinical manifestations nor the age-old markers like ESR, CRP, etc. have proven diagnostic or prognostic of sepsis. This study aims to assess the role of neutrophil: lymphocyte ratio (NLR) in assessing the severity of sepsis within the initial 24 hrs of admission. Methods: Authors did a retrospective observational study in 208 sepsis patients admitted in the MDICU. The NLR was calculated and the study population was grouped into those with an NLR of more than or equal to 5 and those with less than 5. The patients were also grouped based on the number of organs impaired due to sepsis. The association between these groups were then assessed. Results: 46 patients (60.5%) with single organ involvement had NLR <5; 30 patients (39.5%) had NLR >5; 27 patients (42.2%) with two organ involvement had NLR <5 and 37 patients (57.8%) had NLR >5. Among patients with more than two organ involvement, 8 patients (21.6%) had NLR <5 and 29 patients (78.4%) had NLR >5. It was found that there is statistically significant association between increase in number of organs involved and NLR more than 5. The chi square test value was 15.691 with a p value was less than 0.001. Conclusions: In the current study, we have evaluated the role of NLR in sepsis. NLR calculated on the day of admission is a simple parameter that helps to stratify patients into severe risk category. A significant association was found with higher NLR and the number of organs impairment in sepsis.

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Sepsis: A Review of Advances in Management

Cited by 341 publications

References 124 publications

S100A8/A9 modulates inflammatory collateral tissue damage during intraperitoneal origin systemic candidiasis

S100A8/A9 modulates inflammatory collateral tissue damage during intraperitoneal origin systemic candidiasis

Integration Analysis of m6A-SNPs and eQTLs Associated With Sepsis Reveals Platelet Degranulation and Staphylococcus aureus Infection are Mediated by m6A mRNA Methylation

The role of neutrophil/lymphocyte ratio in predicting the severity of sepsis in a tertiary care hospital in South India: a retrospective study

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