Pyonephrosis is a disease, causing suppurative destruction of the renal parenchyma. Fever, chills, and flank pain are most commonly seen. Clinical presentation can include a huge spectrum from asymptomatic bacteriuria (15%) to urinary sepsis, septic shock and death. Palpable abdominal mass, associated with the hydronephrotic kidney can be detected during physical examination. Urinary system infections, obstruction and anatomic variations (such as pelvic kidney, horseshoe kidney) play a role in etiology. We report a 67-year-old woman with giant pyonephrosis accompanied by a huge intraabdominal mass.