Sepsis: recognition and treatment

Soong, Jie Lin; Soni, Neil

doi:10.7861/clinmedicine.12-3-276

Cited by 63 publications

(43 citation statements)

References 27 publications

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“…Sepsis is among the leading causes of morbidity and mortality in critically ill patients and is the most expensive condition by healthcare spending [1–2]. The major tenet of sepsis care is prompt recognition and initiation of treatment.…”

Section: Introductionmentioning

confidence: 99%

Early sepsis detection in critical care patients using multiscale blood pressure and heart rate dynamics

Shashikumar

Stanley

Sadiq

et al. 2017

Journal of Electrocardiology

135

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Sepsis remains a leading cause of morbidity and mortality among intensive care unit (ICU) patients. For each hour treatment initiation is delayed after diagnosis, sepsis-related mortality increases by approximately eight percent. Therefore, maximizing effective care requires early recognition and initiation of treatment protocols. Antecedent signs and symptoms of sepsis can be subtle and unrecognizable (e.g., loss of autonomic regulation of vital signs), causing treatment delays and harm to the patient. In this work we investigated the utility of high-resolution blood pressure (BP) and heart rate (HR) times series dynamics for the early prediction of sepsis in patients from an urban, academic hospital, meeting the third international consensus definition of sepsis (sepsis-III) during their ICU admission. Using a multivariate modeling approach we found that HR and BP dynamics at multiple time-scales are independent predictors of sepsis, even after adjusting for commonly measured clinical values and patient demographics and comorbidities. Earlier recognition and diagnosis of sepsis has the potential to decrease sepsis-related morbidity and mortality through earlier initiation of treatment protocols.

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Section: Introductionmentioning

confidence: 99%

Early sepsis detection in critical care patients using multiscale blood pressure and heart rate dynamics

Shashikumar

Stanley

Sadiq

et al. 2017

Journal of Electrocardiology

135

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“…2 Sepsis may lead to generalized hypoperfusion, multiorgan failure, and finally death. Thus, severe sepsis is defined as a sepsis with sepsis-induced organ dysfunction or tissue hypoperfusion; and whether low blood pressure persists after the administration of intravenous fluids, it is considered as a septic shock.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA haplogroups are associated with severe sepsis and mortality in patients who underwent major surgery

Jiménez‐Sousa

Tamayo

Guzmán-Fulgencio

et al. 2015

Journal of Infection

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“…Sepsis is one of the serious complications of trauma, shock, burns and other critical patients, and can induce multiple organ dysfunction syndromes (MODS) [1]. The core mechanism of sepsis is inflammation.…”

Section: Introductionmentioning

confidence: 99%

Corilagin ameliorates the extreme inflammatory status in sepsis through TLR4 signaling pathways

Liu

Zhang

et al. 2017

BMC Complement Altern Med

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BackgroundSepsis is one of the serious disorders in clinical practice. Recent studies found toll-like receptors 4 (TLR4) played an important role in sepsis. In this study, we tried to find the influence of Corilagin on TLR4 signal pathways in vitro and in vivo.MethodsThe cellular and animal models of sepsis were established by LPS and then interfered with Corilagin. Real-time PCR and western blot were employed to detect the mRNA and protein expressions of TLR4, MyD88, TRIF and TRAF6. ELISA was used to determine the IL-6 and IL-1β levels in supernatant and serum.ResultsThe survival rate was improved in the LPS + Corilagin group, and the mRNA and protein expressions of TLR4, MyD88, TRIF and TRAF6 were significantly decreased than that in the LPS group both in cellular and animal models (P < 0.01). The pro-inflammatory cytokines IL-6 and IL-1β were greatly decreased in the LPS + Corilagin group both in supernatant and serum (P < 0.01).ConclusionsCorilagin exerts the anti-inflammatory effects by down-regulating the TLR4 signaling molecules to ameliorate the extreme inflammatory status in sepsis.

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Sepsis: recognition and treatment

Cited by 63 publications

References 27 publications

Early sepsis detection in critical care patients using multiscale blood pressure and heart rate dynamics

Early sepsis detection in critical care patients using multiscale blood pressure and heart rate dynamics

Mitochondrial DNA haplogroups are associated with severe sepsis and mortality in patients who underwent major surgery

Corilagin ameliorates the extreme inflammatory status in sepsis through TLR4 signaling pathways

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