Sepsis target validation for repurposing and combining complement and immune checkpoint inhibition therapeutics

Rodrigues, Patrícia; Picco, Noemi; Morgan, B. Paul; Ghazal, Peter

doi:10.1080/17460441.2021.1851186

Cited by 8 publications

(7 citation statements)

References 135 publications

(139 reference statements)

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“…Thus, therapeutic intervention moderating the type of immune reaction from a challenge, by targeting in particular, immune checkpoint inhibitors as well as reducing complement activation levels, may hold future promise for the management of sepsis. 48 …”

Section: Sepsis: Reconciling Past and Present Dogmas With Emerging Pa...mentioning

confidence: 99%

Challenging molecular dogmas in human sepsis using mathematical reasoning

et al. 2022

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Section: Sepsis: Reconciling Past and Present Dogmas With Emerging Pa...mentioning

confidence: 99%

Challenging molecular dogmas in human sepsis using mathematical reasoning

et al. 2022

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“…Recently, novel and innovative technologies, such as chromogenic [16], turbidimetric [70], or viscometric [71] methods, have been introduced to improve the accuracy of the LAL test.…”

Section: Endotoxin Detectionmentioning

confidence: 99%

“…In this context, pro-inflammatory reactions are activated with the aim of removing invading pathogens, while anti-inflammatory responses are activated to limit local and systemic tissue injury and damage. The net sum of these antagonistic processes may result in cell death and consequent tissue dysfunction and damage until organ failure [8,9,[11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Endotoxin in Sepsis: Methods for LPS Detection and the Use of Omics Techniques

et al. 2022

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Lipopolysaccharide (LPS) or endotoxin, the major cell wall component of Gram-negative bacteria, plays a pivotal role in the pathogenesis of sepsis. It is able to activate the host defense system through interaction with Toll-like receptor 4, thus triggering pro-inflammatory mechanisms. A large amount of LPS induces inappropriate activation of the immune system, triggering an exaggerated inflammatory response and consequent extensive organ injury, providing the basis of sepsis damage. In this review, we will briefly describe endotoxin’s molecular structure and its main pathogenetic action during sepsis. In addition, we will summarize the main different available methods for endotoxin detection with a special focus on the wider spectrum offered by omics technologies (genomics, transcriptomics, proteomics, and metabolomics) and promising applications of these in the identification of specific biomarkers for sepsis.

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“…The early stage of sepsis is characterized by the excessive systemic inflammatory immune response, and the late stage of sepsis is characterized by continuous immunosuppression ( 5 ). These processes may lead to cell dysfunction and eventually organ failure ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

High Mobility Group Proteins in Sepsis

Liang

2022

Front. Immunol.

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Sepsis, a systemic inflammatory response disease, is the most severe complication of infection and a deadly disease. High mobility group proteins (HMGs) are non-histone nuclear proteins binding nucleosomes and regulate chromosome architecture and gene transcription, which act as a potent pro-inflammatory cytokine involved in the delayed endotoxin lethality and systemic inflammatory response. HMGs increase in serum and tissues during infection, especially in sepsis. A growing number of studies have demonstrated HMGs are not only cytokines which can mediate inflammation, but also potential therapeutic targets in sepsis. To reduce sepsis-related mortality, a better understanding of HMGs is essential. In this review, we described the structure and function of HMGs, summarized the definition, epidemiology and pathophysiology of sepsis, and discussed the HMGs-related mechanisms in sepsis from the perspectives of non-coding RNAs (microRNA, long non-coding RNA, circular RNA), programmed cell death (apoptosis, necroptosis and pyroptosis), drugs and other pathophysiological aspects to provide new targets and ideas for the diagnosis and treatment of sepsis.

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Sepsis target validation for repurposing and combining complement and immune checkpoint inhibition therapeutics

Cited by 8 publications

References 135 publications

Challenging molecular dogmas in human sepsis using mathematical reasoning

Challenging molecular dogmas in human sepsis using mathematical reasoning

Endotoxin in Sepsis: Methods for LPS Detection and the Use of Omics Techniques

High Mobility Group Proteins in Sepsis

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