Septic shock caused by Streptococcus suis: Case report and investigation of a risk group

Strangmann, Elke; Fröleke, Hartmut; Kohse, Klaus P.

doi:10.1078/1438-4639-00165

Cited by 53 publications

(43 citation statements)

References 24 publications

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“…Of the 35 capsular serotypes currently described, serotype 2 S. suis strains are most frequently associated with swine disease (21). In addition, humans handling infected pigs or derived products are at risk of infection (39), resulting in potentially fatal diseases such as septicemia, endocarditis, and meningitis (9), as well as postinfection sequalae, including deafness and arthritis (44).…”

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confidence: 99%

Investigation of a Novel DNase of Streptococcus suis Serotype 2

2004

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A secreted nuclease, SsnA, was identified in the virulent Streptococcus suis isolate SX332 and subsequently in each of the type strains of capsular serotypes 1 through 9. Screening of 258 porcine clinical isolates from surface (nasal mucosa or palatine tonsil) or internal (joint, brain or other internal organ) locations revealed a significant relationship (P < 0.001) between expression of nuclease and isolation from an internal site. A 3,126-bp gene, ssnA, was identified from a phenotypically nuclease-negative pGh9:ISS1 insertion mutant, and analysis of the predicted SsnA sequence revealed a 35-amino-acid (aa) secretion signal sequence, a 22-aa DNA-binding domain, and a typical gram-positive cell wall sorting motif. A requirement of Ca 2؉ and Mg 2؉ for SsnA activity was determined, and the substrate specificity was found to be for single-and double-stranded linear DNA. Reverse transcription-PCR experiments revealed that ssnA is expressed throughout all stages of S. suis growth, and Western blots with porcine anti-S. suis immune sera against a recombinant, truncated SsnA derivative (rSsnA ⌬ ) confirmed that SsnA is expressed in vivo. Furthermore, anti-rSsnA ⌬ antibodies were sufficient to neutralize SsnA activity. Analyses of subcellular fractions of SX332 and derived mutants, on DNAcontaining polyacrylamide gels and by Western blotting, suggest that SsnA is cell wall located.

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confidence: 99%

Investigation of a Novel DNase of Streptococcus suis Serotype 2

2004

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“…Al respecto, un estudio de seroprevalencia realizado en Holanda, reveló presencia de anticuerpos contra S. suis serotipo 2 en 6% de un grupo de 102 veterinarios, y en 1% de 191 criadores de cerdos 6,23 . Un reporte realizado en Alemania sobre portación nasofaríngea, realizado en un grupo de 132 individuos con exposición laboral recurrente (carniceros, empleados procesadores de carne), demostró que 5,3% eran portadores; en cambio, no se encontraron portadores en el grupo control (130 individuos) 6,24 .…”

Section: Discussionunclassified

Meningitis bacteriana aguda por Streptococcus suis en criadores de cerdos: comunicación de los primeros dos casos en Chile

Koch

Fuentes

Carvajal

et al. 2013

Rev. chil. infectol.

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“…Studies observed that longer duration of exposure to pigs and pork affects S. suis carriage in the population Smith et al 2008;Strangmann et al 2002). Infection rate in individuals with high-risk exposures is estimated to be 1500 times higher than that of the general population (Lun et al 2007;Arends and Zanen 1988).…”

Section: Streptococcus Suismentioning

confidence: 98%

Zoonotic Diseases of Swine: Food-borne and Occupational Aspects of Infection

Thapaliya

Hanson

Kates

et al. 2014

Zoonoses - Infections Affecting Humans and Animals

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Swine and their products have become a central part of food systems around the world. Global pork production has rapidly increased over the past 30 years, leading to the intensification of the swine industry: though there are fewer farms now, those farms that do persist raise ever-larger numbers of animals. This increases the transmission of pathogens both amongst animal herds, and between animals and their human caretakers. Furthermore, increased stress to animals and the potential for amplification of pathogens in the farming environment can lead to a higher burden of disease-causing organisms in and on meat products, which then make their way to consumers world-wide. As such, swine and their meat products have the potential to introduce new zoonotic diseases into populations via multiple routes of transmission. Here we discuss several examples of zoonotic diseases of swine origin, reviewing diseases with bacterial, viral, or parasitic causes. Background and IntroductionPork is rapidly becoming the world's source of protein. Global pork production increased more than 80 % between 198580 % between and 201080 % between (Fournie et al. 2012, and this trend has led to the intensification of swine husbandry, with fewer and fewer facilities present, but each raising larger numbers of individual animals. China has been a driver of this market, accounting for approximately 50 % of total global pig production (Fournie et al. 2012). As swine production has intensified, so has concern over how these modifications in husbandry may affect the transmission of disease amongst pigs as well as to human caretakers. It has been estimated that more than 60 % of emerging diseases are zoonotic (Jones et al. 2008). A recent review (Fournie et al. 2012) identified 77 pathogens that had not been described in swine prior to 1985, including 39 viruses and 32 bacterial species. Not surprisingly, the top 20 % of pork-producing countries accounted for 82 % of these emerging pathogens. Of these 77 novel species found to infect swine, 30 (39 %) are zoonotic, and 23

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Septic shock caused by Streptococcus suis: Case report and investigation of a risk group

Cited by 53 publications

References 24 publications

Investigation of a Novel DNase of Streptococcus suis Serotype 2

Investigation of a Novel DNase of Streptococcus suis Serotype 2

Meningitis bacteriana aguda por Streptococcus suis en criadores de cerdos: comunicación de los primeros dos casos en Chile

Zoonotic Diseases of Swine: Food-borne and Occupational Aspects of Infection

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