Septic thrombophlebitis with acute osteomyelitis in adolescent children: a report of two cases and review of the literature

Abstract

The triad of acute osteomyelitis, deep venous thrombophlebitis, and septic pulmonary embolism is a rare, but life-threatening syndrome in children that requires prompt recognition and treatment. We report two cases of acute osteomyelitis complicated by septic thrombophlebitis and pulmonary emboli. Both patients required operative drainage to remove the septic focus. Recognition of any one component of the triad should prompt a search for the other associated disorders. Aggressive management with early antibiotic administration, anticoagulation, and surgical debridement can be life saving.

Deep venous thrombosis in children with musculoskeletal infections: the clinical evidence

“…Seventeen of the 28 included studies were case reports. 6,7,10,13,[15][16][17][18][19][20][22][23][24][25]27,30,31 The remaining 11 were case series/cohort studies, seven of which had a retrospective design, 5,8,9,14,21,26,29 and four a prospective design. 4,11,12,28 In addition, three of the 28 included studies provided comparative data regarding patients with MSIs who developed DVT and patients who did not.…”

A Case of Atypical Skull Base Osteomyelitis with Septic Pulmonary Embolism

“…The triad of osteomyelitis, deep venous thrombophlebitis and septic pulmonary embolism is a rare, but life-threatening syndrome that requires prompt recognition and treatment ( 6 ). Recognition of any one of the triad should prompt a search for the other associated conditions.…”

“…Septic cavernous sinus thrombosis complicated by multiple pulmonary septic emboli was described by Hoshino et al ( 5 ). Some children presenting with septic pulmonary emboli and deep venous thrombosis secondary to acute osteomyelitis of the long bones have been also reported ( 6 ). Here we describe the first, to the best of our knowledge, case of atypical SBO caused by masked mastoiditis complicated by sigmoid sinus thrombosis and multiple septic pulmonary emboli; the patient was successfully treated with antibiotics and anticoagulants.…”

Achromobacter causing a thrombophlebitis and osteomyelitis combination: a rare cause

“…To the best of our knowledge, ours is the second thrombophlebitis case, secondary to Achromobacter , reported in the literature 3. There are also a few reports of osteomyelitis following thrombophlebitis, but none of them were caused by Achromobacter 4 5. We aim to focus on this rare opportunistic water pathogen and emphasise the combination of osteomyelitis and thrombophlebitis.…”