Sequence Homology Between the RNA of Mason-Pfizer Monkey Virus and the RNA of Human Malignant Breast Tumors

Abstract

Radioactive DNA ([3HlcDNA)

Squirrel monkey retrovirus: an endogenous virus of a new world primate

“…The virus was incubated on ice for 10 min and then diluted to 100 ,ul containing the following: 500 ,ug of bovine serum albumin per ml, 62 mM Tris-hydrochloride (pH 8.3), 40 ,ug of oligo(dG) * poly(rC) (Bethesda Research) per ml, 50 ,ug of actinomycin D per ml, 200 ,uCi of [3H]dGTP (9.4 Ci/mM; New England Nuclear) per ml, and varying amounts of monovalent and divalent cations as specified in the legends to the figures and tables. Other enzyme assays were performed as described previously (8,18).…”

1984—Discovery of the First Anti-HIV Drug, Suramin

“…In the 1970s, the possible role of RT in the pathogenesis of cancer became a real hype after Sol Spiegelman had first reported the presence of RT in various virions including visna [ 9 ], and those isolated from mammary carcinoma [ 10 , 11 ], and murine leukemia [ 12 ]. It was further reported in a dazzling number of papers in PNAS [ 13 , 14 , 15 , 16 , 17 , 18 ], that all sorts of human cancer (breast cancer, leukemia, Burkitt’s lymphoma, brain tumors, Hodgkin’s lymphoma, gastrointestinal and lung malignancies, and malignant breast tumors) displayed enhanced RT levels.…”

Detection in human breast carcinomas of an antigen immunologically related to a group-specific antigen of mouse mammary tumor virus

“…(b) What is the chemical nature of the gp52 crossreacting antigen found in human breast cancer cells? (c) Can additional specific antigens be detected by using antisera to other oncornaviruses (e.g., Mason-Pfizer monkey virus) with suspected (22,23) crossreactivities?…”