Sequence polymorphism of the mitochondrial DNA hypervariable regions I and II in 205 Singapore Malays

Wong, Hang Yee; Tang, June S.W.; Budowle, Bruce; Allard, Marc W.; Syn, Christopher Kiu Choong; Tan-Siew, Wai Fun; Chow, Shui Tse

doi:10.1016/j.legalmed.2006.08.007

Cited by 17 publications

(34 citation statements)

References 7 publications

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“…M12b is a Cambodian-specific haplogroup with moderate prevalence (8.25%) in Cambodians, which was firstly defined by Fucharoen et al 35 , with sporadic presence in northern India 25 , southwestern China (Yunnan province) [36][37][38] , northern Thailand 35,39 , Laos 9 and ISEA 12,40 . The reduced median network of M12b (Fig.…”

Section: Classification Of the Cambodian Mtdna Haplogroupsmentioning

confidence: 99%

Analysis of mitochondrial genome diversity identifies new and ancient maternal lineages in Cambodian aborigines

Zhang

Yang

et al. 2013

Nat Commun

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Section: Classification Of the Cambodian Mtdna Haplogroupsmentioning

confidence: 99%

Analysis of mitochondrial genome diversity identifies new and ancient maternal lineages in Cambodian aborigines

Zhang

Yang

et al. 2013

Nat Commun

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“…We referred to the classification trees proposed by Palanichamy et al [ Table S1. The M7b1 haplotype has been found throughout East and Southeast Asia in the Korean (0.3%) [18][19][20][21], Chinese (1.8%) [22][23][24][25][26][27][28][29], Japanese (0.15%) [5,9,[30][31][32][33][34][35], Thai (1.9%) [36], Singapore Malay (2.4%) [3], Southern Chinese Daic and Austro-Asiatic (7.7%) [37], Vietnamese (6.95%) [38], Aboriginal Taiwanese (3.3% and 0.74%) [39,40], and Island Southeast Asian populations (1.4%) [14,15,41], but not in the Aboriginal Malay population [14,41]. Of the present M7b1 individuals, two had the intergenic COII/ tRNALys 9-bp deletion.…”

Section: Phylogenetic Studiesmentioning

confidence: 99%

“…This motif is frequent in the Island Southeast Asian (8.3%) [15], Aboriginal Taiwanese (4.4% and 7.87%) [39,40], Aboriginal Malay (5.8%) [14,41], Singapore Malay (10%) [3], and Vietnamese (2.7%) [38] populations; is rare in the Chinese (0.5%) [22][23][24][25][26][27][28][29], Thai (0.5%) [36], and Southern Chinese Austro-Asiatic and Daic (0.1%) [37] populations; and has never been found in the Japanese [5,9,[30][31][32][33][34][35] or Korean [18][19][20][21] populations.…”

Section: Phylogenetic Studiesmentioning

confidence: 99%

“…Recent research on mtDNA sequence data in the forensic field has begun to encompass the complete control region sequence, with the aim of obtaining more information on polymorphisms and more reliable indicators of phylogenetic haplogroup than those based on the HV1 and HV2 regions alone. Although knowledge of mtDNA polymorphisms of the control region in the East Asian population is increasing, only two reports have investigated large numbers of the modern Malay population [2,3]. One of these reports did not present a database on control region polymorphisms [2] and the other reported only HV1 (16024-16364) and HV2 (73-340) region information and did not show haplogroups [3].…”

Section: Introductionmentioning

confidence: 99%

“…Although knowledge of mtDNA polymorphisms of the control region in the East Asian population is increasing, only two reports have investigated large numbers of the modern Malay population [2,3]. One of these reports did not present a database on control region polymorphisms [2] and the other reported only HV1 (16024-16364) and HV2 (73-340) region information and did not show haplogroups [3]. Therefore, the details of the phylogenetic characteristics and control region variations of the modern Malay population remain to be clarified.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia

et al. 2009

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Control region polymorphisms in the mitochondrial DNA of 124 unrelated individuals from the Malay population living in or around Kuala Lumpur in Malaysia were investigated and phylogenetic haplogroup lineages were determined. The intergenic COII/tRNALys 9-bp deletion, 3010 and 5178 mutations, and several coding region polymorphisms were examined to discriminate some phylogenetic haplogroups. Sequence comparison of the control regions led to the identification of 117 mitochondrial haplotypes, in which 103 types were observed in only one individual and the other nine types were shared by more than two individuals. Gene diversity was estimated to be 0.997. Phylogenetic haplogroup determination revealed that the gene pool of the modern Malay population in Malaysia consisted mainly of southeast Asian, east Asian, unidentified and unique, and aboriginal southeast-specific haplogroups. These results suggest a multi-original nature for the modern Malay population. The present database may help not only in personal identification but also in determining geographic origin in forensic casework in Malaysian, Southeast Asian and East Asian populations.

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Forensic and phylogeographic characterization of mtDNA lineages from northern Thailand (Chiang Mai)

et al. 2009

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The immigration of diverse ethnic groups over the past centuries from surrounding countries into Thailand left footprints in the genetic composition of Thai mitochondrial DNA (mtDNA) lineages. The entire mtDNA control region (1,122 bp) was typed in 190 unrelated male volunteers from the northern Thailand province of Chiang Mai following highest quality standards. For a more precise haplogroup classification, selected single nucleotide polymorphisms from the mtDNA coding region were genotyped. We found several new, so far undescribed mtDNA lineages. Quasi-median networks were constructed for visualisation of character conflicts. The data were put into population-genetic relationships with other Southeast Asian populations. Although the frequencies of the Thai haplogroups were characteristic for Southeast Asia in terms of haplotype composition and genetic structure, the Thai population was significantly different from other Southeast Asian populations. This necessitates establishing regional databases, especially for forensic applications. The population data have been submitted to the EMPOP database (www.empop.org) and will be available on publication.

show abstract

Sequence polymorphism of the mitochondrial DNA hypervariable regions I and II in 205 Singapore Malays

Cited by 17 publications

References 7 publications

Analysis of mitochondrial genome diversity identifies new and ancient maternal lineages in Cambodian aborigines

Analysis of mitochondrial genome diversity identifies new and ancient maternal lineages in Cambodian aborigines

MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia

Forensic and phylogeographic characterization of mtDNA lineages from northern Thailand (Chiang Mai)

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