2006
DOI: 10.1158/1055-9965.epi-05-0874
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Sequence Variants in Toll-Like Receptor 10 Are Associated with Nasopharyngeal Carcinoma Risk

Abstract: Nasopharyngeal carcinoma (NPC) is a common malignancy in southern China and Southeast Asia. Genetic susceptibility is a major factor in determining the individual risk of NPC in these areas. To test the association between NPC and variants in Toll-like receptor 10 (TLR10), we conducted a hospital-based case-control study in a Cantonese-speaking population in Guangdong province. Seven single nucleotide polymorphisms in TLR10, selected with a tagging algorithm, were genotyped. When assessing each unique haplotyp… Show more

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Cited by 51 publications
(36 citation statements)
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“…15 Four mRNA isoforms have been identified, but all encode the same protein (http://www.ncbi.nlm.nih.gov/sites/entrez). Variations within the TLR10-TLR1-TLR6 gene cluster have been associated with several diseases, including asthma, 16,17 prostate cancer, 18 nasopharyngeal carcinoma, 19 non-Hodgkin lymphoma, 20 Lyme disease 21 and atherogenesis. 22 However, association between the TLR10-TLR1-TLR6 gene cluster and CD has not been yet studied.…”
Section: Introductionmentioning
confidence: 99%
“…15 Four mRNA isoforms have been identified, but all encode the same protein (http://www.ncbi.nlm.nih.gov/sites/entrez). Variations within the TLR10-TLR1-TLR6 gene cluster have been associated with several diseases, including asthma, 16,17 prostate cancer, 18 nasopharyngeal carcinoma, 19 non-Hodgkin lymphoma, 20 Lyme disease 21 and atherogenesis. 22 However, association between the TLR10-TLR1-TLR6 gene cluster and CD has not been yet studied.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, its biological function is not well established yet. However, TLR10 gene has been revealed the genetic associations with infection or immune disease and has been suggested as susceptible factor [14,15,17,24]. Mailaparambil et al studied the association between 19 polymorphisms of TLR genes (TLR1, 2, 3, 5, 6,9) and infection by respiratory syncytial virus (RSV) and suggested the association of one TLR9 promoter polymorphism and TLR10 haplotypes [17].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, studies have reported genetic polymorphisms of TLR10 in humans in association with diverse diseases, including Crohn's disease (7), asthma (8), urothelial bladder cancer (9), and nasopharyngeal cancer (10). Furthermore, TLR10 expression is also reported to be induced in response to reactive oxygen species in hypoxic cells (11).…”
mentioning
confidence: 99%