Sequence Variants on Chromosome 9p21 Are Associated with Ischemic Stroke and the Lipids Level in Chinese Han Population

Bi, Jiajia; Yang, Lin; Liú, Dan; Wu, Jun; Tong, Xiaoxin; Cen, Shuangshuang; Zhou, Da; Zhang, Ting; Li, Yang

doi:10.1016/j.jstrokecerebrovasdis.2014.12.020

Cited by 10 publications

(10 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of rs10757278 in IS was analyzed in 10 studies [ 20 , 23 , 24 , 27 , 28 , 30 , 35 , 36 , 40 , 42 ] involving 9,352 cases and 2, 4552 controls. A positive association was found in the whole studied population, and in Asians and Caucasians with IS using the combined results.…”

Section: Resultsmentioning

confidence: 99%

“…The role of rs1537378 in IS was analyzed in six studies [ 23 , 27 , 28 , 35 , 36 , 40 ] involving 6,166 cases and 6,129 controls. The CC genotype was found to increase the risk for IS in the whole studied population (OR = 1.18, 95%CI: 1.09–1.27, p-FDR = 0.000) ( Fig 10 ), in Asians (OR = 1.43, 95%CI: .1.20–1.71, p-FDR = 0.000), and in Caucasians (OR = 1.21, 95%CI: 1.07–1.37, p-FDR = 0.003).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Genetic association of ANRIL with susceptibility to Ischemic stroke: A comprehensive meta-analysis

et al. 2022

View full text Add to dashboard Cite

Background Ischemic stroke (IS) is a complex polygenic disease with a strong genetic background. The relationship between the ANRIL (antisense non-coding RNA in the INK4 locus) in chromosome 9p21 region and IS has been reported across populations worldwide; however, these studies have yielded inconsistent results. The aim of this study is to clarify the types of single-nucleotide polymorphisms on the ANRIL locus associated with susceptibility to IS using meta-analysis and comprehensively assess the strength of the association. Methods Relevant studies were identified by comprehensive and systematic literature searches. The quality of each study was assessed using the Newcastle-Ottawa Scale. Allele and genotype frequencies were extracted from each of the included studies. Odds ratios with corresponding 95% confidence intervals of combined analyses were calculated under three genetic models (allele frequency comparison, dominant model, and recessive model) using a random-effects or fixed-effects model. Heterogeneity was tested using the chi-square test based on the Cochran Q statistic and I2 metric, and subgroup analyses and a meta-regression model were used to explore sources of heterogeneity. The correction for multiple testing used the false discovery rate method proposed by Benjamini and Hochberg. The assessment of publication bias employed funnel plots and Egger’s test. Results We identified 25 studies (15 SNPs, involving a total of 11,527 cases and 12,216 controls maximum) and performed a meta-analysis. Eight SNPs (rs10757274, rs10757278, rs2383206, rs1333040, rs1333049, rs1537378, rs4977574, and rs1004638) in ANRIL were significantly associated with IS risk. Six of these SNPs (rs10757274, rs10757278, rs2383206, rs1333040, rs1537378, and rs4977574) had a significant relationship to the large artery atherosclerosis subtype of IS. Two SNPs (rs2383206 and rs4977574) were associated with IS mainly in Asians, and three SNPs (rs10757274, rs1333040, and rs1333049) were associated with susceptibility to IS mainly in Caucasians. Sensitivity analyses confirmed the reliability of the original results. Ethnicity and individual studies may be the main sources of heterogeneity in ANRIL. Conclusions Our results suggest that some single-nucleotide polymorphisms on the ANRIL locus may be associated with IS risk. Future studies with larger sample numbers are necessary to confirm this result. Additional functional analyses of causal effects of these polymorphisms on IS subtypes are also essential.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Genetic association of ANRIL with susceptibility to Ischemic stroke: A comprehensive meta-analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…8,10,11 Four studies with 2512 cases and 2981 controls 7–10 met the criteria for inclusion for rs10757274, and four studies with 3074 cases and 3517 controls were included for rs10757278. 6,8,10,12 Table 2 scored all included studies according to NOS.…”

Section: Resultsmentioning

confidence: 99%

“…8,10,11 Four studies with 2512 cases and 2981 controls 7-10 met the criteria for inclusion for rs10757274, and four studies with 3074 cases and 3517 controls were included for rs10757278. 6,8,10,12 Table 1 displays detailed characteristics of studies. The diagnostic bases of cases, allele designations and frequencies, matching criteria for controls, genotyping methods, and numbers of cases and controls were extracted, and the HWE values of the controls were calculated.…”

Section: Selections Of Studiesmentioning

confidence: 99%

Genetic variants on chromosome 9p21 confer risks of cerebral infarction in the Chinese population: a meta-analysis

Chen

Liu

Feng

et al. 2019

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Ischemic stroke (IS) is the leading cause of disability. Researchers have demonstrated that IS is more a multifactorial disorder than a single-factor disease. At present, no consistent conclusions have been reached on susceptibility loci for IS on chromosome 9p21. We conducted this meta-analysis to verify whether genetic loci on chromosome 9p21 reported domestically and abroad could be responsible for IS in Chinese populations. We analyzed data from eight studies that covered a total of 9756 individuals with Chinese ancestry comprising 4254 cases and 5502 controls. Each of the four reported susceptibility loci (rs2383206, rs2383207, rs10757274, and rs10757278) was analyzed separately. The odds ratios (ORs) of rs2383206 and rs10757274 were 1.09 (95% confidence interval (CI): 1.02–1.06, P = 0.01) and 1.09 (95% CI: 1.01–1.17, P = 0.03), respectively. For rs2383207, OR value was 0.91 (95% CI: 0.84–0.98, P = 0.01). No statistical association was identified for rs10757278. We have verified previous associations for IS in Chinese populations on chromosome 9p21. Loci rs2383206 and rs10757274 may increase susceptibility to IS. Mutation at locus rs2383207 may be beneficial. However, we are unable to identify any association between rs10757278 and IS.

show abstract

“…Common variants in the region on chromosome 9p21 have recently been associated with increased risk for coronary arterial disease (CAD) by a number of parallel genome-wide association studies (GWAS) in Caucasians [7][8][9][10], and this result was further confirmed by several independent case control studies in Caucasians [11]. Replication studies have been successful in Japanese, Korean and Chinese Han populations [12][13][14]15] although genetic heterogeneity has been reported in blacks [9][10] [ 15 16]. From these studies, the interval of core risk region at 9p21 locus has been defined within a 44kb LD block in Caucasians [11].…”

Section: Introductionmentioning

confidence: 96%

A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population

Li¹,

Xu²,

Zheng³

et al. 2017

IJGG

View full text Add to dashboard Cite

Abstract:The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between Southern and Northern Chinese Han populations could be one of the reasons for this uncertainty. Four genetic variants selected from the three conjunctional LD blocks within the 44 kb candidate region on chromosome 9p21 were genotyped in 1,429 IS patients and 1,191 healthy controls from the Northern Chinese Han population. Among the four studied variants, the G allele of the SNP rs2383207 was significantly associated with IS with allele frequency 66.8% in patients and 63.4% in controls. This association appears to be dominant with an OR of 1.417 (p=0.003) for people with either GG or AG genotypes. We did not find any association for the other three SNPs (rs1333049, rs10757274, and rs10116277). Based our results, we conclude that the 9p21 locus is a susceptibility locus for IS in the Northern Chinese Han population; and the core risk region for IS is within an interval of less than 28kb.

show abstract

Sequence Variants on Chromosome 9p21 Are Associated with Ischemic Stroke and the Lipids Level in Chinese Han Population

Cited by 10 publications

References 33 publications

Genetic association of ANRIL with susceptibility to Ischemic stroke: A comprehensive meta-analysis

Genetic association of ANRIL with susceptibility to Ischemic stroke: A comprehensive meta-analysis

Genetic variants on chromosome 9p21 confer risks of cerebral infarction in the Chinese population: a meta-analysis

A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population

Contact Info

Product

Resources

About