Sequence variation of bradykinin receptors B1 and B2 and association with hypertension

Cui, Jing; Melista, Efthymia; Chazaro, Irmarie; Zhang, Yuejian; Zhou, Xiaofeng; Manolis, Athanasios; Baldwin, Clinton T.; DeStefano, Anita L.; Gavras, Haralambos

doi:10.1097/00004872-200501000-00013

Cited by 33 publications

(16 citation statements)

References 13 publications

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“…8,9 Whites with essential hypertension were recruited from hypertension clinics at Boston Medical Center, Boston, Mass, and the Tzanion Hospital, Piraeus, Greece, and have been described elsewhere. 21 African-American hypertensives were recruited from the hypertension clinics at Boston Medical Center. Affected individuals either had blood pressures Ͼ140 mm Hg or were receiving antihypertensive medication.…”

Section: Methodsmentioning

confidence: 99%

Association of NEDD4L Ubiquitin Ligase With Essential Hypertension

Russo¹,

Melista²,

Cui³

et al. 2005

Hypertension

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Abstract-NEDD4L is a ubiquitin ligase that controls cell surface expression of kidney epithelial Na ϩ channels by ubiquitin-mediated endocytosis and lysosome targeting. Thus, it is a significant determinant of Na ϩ reabsorption in the distal nephron. The NEDD4L gene is located on human chromosome 18q21 within several blood pressure quantitative trait loci, including those for familial orthostatic hypotension, essential hypertension, pulse pressure, and systolic blood pressure response to postural challenge. Because of the importance of NEDD4L to Na ϩ balance, many of these studies have proposed that mutations in NEDD4L may be responsible for these blood pressure phenotypes. To test this hypothesis, we fine-mapped the NEDD4L region in 2 families with orthostatic hypotension, which we previously reported to be linked to human chromosome 18q21 but failed to implicate NEDD4L in these families. We also typed multiple NEDD4L single-nucleotide polymorphisms (SNPs) in a collection of US whites, Greek whites, and African-Americans individuals with essential hypertension. A significant association between several SNPs and hypertension was observed in all 3 populations. One of the SNPs associated in African Americans is known to result in premature truncation of the NEDD4L protein. Thus, genetic variation in NEDD4L may play a role in the development or progression of some forms of abnormal blood pressure.

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Section: Methodsmentioning

confidence: 99%

Association of NEDD4L Ubiquitin Ligase With Essential Hypertension

Russo¹,

Melista²,

Cui³

et al. 2005

Hypertension

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“…Earlier studies already associated the þ 9 bp with decreased BDKRB2 transcriptional activity, 5 an increased systolic BP, 10 and an elevated prevalence of that allele in hypertensives compared with a normotensive population. 11 These data taken together suggest a pathophysiologic mechanism by which the bradykinin type 2 receptor contributes to the development of hypertension. In the present report, we did not confirm this presumed association, suggesting that the þ 9 bp variant of BDKRB2 might not confer susceptibility to hypertension in the evaluated population.…”

mentioning

confidence: 92%

Insertion/deletion polymorphism of the bradykinin type 2 receptor gene influence diastolic blood pressure

et al. 2009

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“…A variant in BDKRB1 (-699 G>C) was slightly associated with progression of polycystic kidney disease (Tazón-Vega et al, 2007) but also with the risk of inflammatory bowel disease . BDKRB1 variants were also reported in the context of hypertension (Cui et al, 2005).…”

Section: Or Attentiondeficit Hyperactivity Disorder (Elia Et Al 2009)mentioning

confidence: 93%

Pharmacogenetics of new analgesics

Lötsch

Geißlinger

2011

British J Pharmacology

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Patient phenotypes in pharmacological pain treatment varies between individuals, which could be partly assigned to their genotypes regarding the targets of classical analgesics (OPRM1, PTGS2) or associated signalling pathways (KCNJ6). Translational and genetic research have identified new targets, for which new analgesics are being developed. This addresses voltage-gated sodium, calcium and potassium channels, for which SCN9A, CACNA1B, KCNQ2 and KCNQ3, respectively, are primary gene candidates because they code for the subunits of the respective channels targeted by analgesics currently in clinical development. Mutations in voltage gated transient receptor potential (TRPV) channels are known from genetic pain research and may modulate the effects of analgesics under development targeting TRPV1 or TRPV3. To this add ligand-gated ion channels including nicotinic acetylcholine receptors, ionotropic glutamate-gated receptors and ATP-gated purinergic P2X receptors with most important subunits coded by CHRNA4, GRIN2B and P2RX7. Among G protein coupled receptors, d-opioid receptors (coded by OPRD1), cannabinoid receptors (CNR1 and CNR2), metabotropic glutamate receptors (mGluR5 coded by GRM5), bradykinin B1 (BDKRB1) and 5-HT1A (HTR1A) receptors are targeted by new analgesic substances. Finally, nerve growth factor (NGFB), its tyrosine kinase receptor (NTRK1) and the fatty acid amide hydrolase (FAAH) have become targets of interest. For most of these genes, functional variants have been associated with neuro-psychiatric disorders and not yet with analgesia. However, research on the genetic modulation of pain has already identified variants in these genes, relative to pain, which may facilitate the pharmacogenetic assessments of new analgesics. The increased number of candidate pharmacogenetic modulators of analgesic actions may open opportunities for the broader clinical implementation of genotyping information. AbbreviationsAMPA, a-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; CB1, cannabinoid receptor 1; CB2, cannabinoid receptor 2; COX-2, prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); FAAH, fatty acid amide hydrolase; Il-1, interleukin 1; MAO, monoamine oxidase; mGluR5, metabotropic glutamate receptor 5; nAChR, neuronal nicotinic acetylcholine receptors; Nav, voltage-gated sodium channels; NGF, nerve growth factor; NMDA, N-methyl-D-aspartic acid; NR2B, NR2B Subunit of the NMDA receptor; P2X7, purinergic receptor P2X, ligand-gated ion channel, 7; TRPV1, transient receptor potential cation channel, subfamily V, member 1; TRPV3, transient receptor potential cation channel, subfamily V, member 3

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Sequence variation of bradykinin receptors B1 and B2 and association with hypertension

Abstract: These results support the hypothesis that the African-American population is an older population compared with the other samples and the two bradykinin receptors may play a role in blood pressure regulation.

Cited by 33 publications

References 13 publications

Association of NEDD4L Ubiquitin Ligase With Essential Hypertension

Association of NEDD4L Ubiquitin Ligase With Essential Hypertension

Insertion/deletion polymorphism of the bradykinin type 2 receptor gene influence diastolic blood pressure

Pharmacogenetics of new analgesics

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