Sequential changes of serum and liver subcellular oxidants and antioxidant concentrations in silymarin treated male rats

Al-Sa, J.A.A.; aidi, A; Shoabith, H.J.

doi:10.33899/ijvs.2016.116862

Cited by 1 publication

(1 citation statement)

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“…In many studies, silymarin and silibin are used in human as hepatoprotective substances, where it has been found that silymarin provide significant protection against experimental hepatotoxicity in laboratory animals. Their effects are related mainly to the anti-oxidative (7), analgesic (8) anti-lipid peroxidative mechanisms, antidiabetic, and hepatoprotective effects (9).…”

Section: Introductionmentioning

confidence: 99%

Ovario-utero protective effect of silymarin in ethidium bromide treated female rats

Abdulshaheed¹,

Al-Saaidi²,

Al-Arak³

2022

IJVS

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This study was conducted to qualify the ameliorating potency of silymarin against toxicity in ethidium bromide (EtBr) treated female rats. Eighty female Wistar rats aged 100 days, weighted 170-175 g were randomly allocated to control, orally supplemented with drinking water, and three treated groups, orally supplemented with silymarin 200 mg/kg BW, EtBr 10 mg/kg BW, and combination of EtBr and silymarin (SEtBr), respectively. Each group was allocated to two subgroups, sacrificed after 20 and 40 days of treatment. Bodyweight gain, uteri, and ovaries weight were recorded. Ovarian samples were obtained for histopathological examination. EtBr group females recorded the lowest body weight gain, relative weights of ovaries and uteri, and ovarian follicle number, whereas S group females recorded the highest body weight gain and follicular number, while the ovaries and uteri weights were either higher or close to the control group, at both experimental periods. Histopathological findings of both periods revealed necrosis, cirrhosis, ischemia, and prominent hemorrhage in the blood capillaries in EtBr treated ovarian tissues, but many of the ovarian follicles being mature and the atretic follicles were hence found to be high in number, whereas silymarin treated females showed normal ovarian tissues and viable ovarian follicles as that in control females. The combinationtreated females, at 20 days, revealed necrotic primary ovarian follicles with some macrophages infiltration, whereas 40 days' period showed normal ovarian cortex, medulla, and ovarian follicles. In conclusion, silymarin treatment in combination with EtBr has a potent amelioration effect against ovarian toxicity, in a duration-dependent manner.

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Section: Introductionmentioning

confidence: 99%