Sequential Ewing's sarcoma and osteosarcoma

Sharma, Vivek; Crawford, Alvin H.; Evans, Jonathan; Collins, Margaret H.

doi:10.1097/bpb.0b013e3283150615

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…To the best of our knowledge, this is the only reported case in the literature of a second primary malignancy in a patient with adamantinoma [ 45 ]. There are no known germline mutations associated with adamantinoma.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Follow-Up of Adamantinoma of the Tibia Complicated by Metastases and a Second Unrelated Primary Cancer: A Case Report and Literature Review

Southam

Crawford

Billmire

et al. 2018

Case Reports in Orthopedics

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Adamantinoma is a rare, low-grade malignant tumor of the bone which grows slowly and typically occurs in the diaphysis of long bones, particularly in the tibia. Adamantinomas have the potential for local recurrence and may metastasize to the lungs, lymph nodes, or bone. We report a case of a 14-year-old female with a tibial adamantinoma who underwent wide resection with limb salvage and has subsequently been followed up for 18 years. The patient went on to have both a local soft tissue recurrence 5 years after the resection and metastases to both an inguinal lymph node and the right lower lobe of the lung 8 years after that recurrence, all of which have been treated successfully with marginal resections. Unique to this case, the patient was also incidentally found to have chromophobe-type renal cell carcinoma when undergoing a partial nephrectomy to resect a presumed metastasis of her adamantinoma. Genetic testing has not revealed any known genetic predisposition to cancer.

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Section: Discussionmentioning

confidence: 99%

Long-Term Follow-Up of Adamantinoma of the Tibia Complicated by Metastases and a Second Unrelated Primary Cancer: A Case Report and Literature Review

Southam

Crawford

Billmire

et al. 2018

Case Reports in Orthopedics

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Diagnosis of osteosarcoma in a patient previously treated for Ewing sarcoma

et al. 2014

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Primary malignant bone tumors, whether Ewing sarcoma or osteosarcoma, are a rare type of tumor. The sequential occurrence of two bone sarcomas, Ewing sarcoma and high-grade osteosarcoma, in the same patient at two different locations is an exceptionally rare phenomenon. We present the case of a 13-year-old girl who presented with a high-grade osteoblastic osteosarcoma of the distal femur, 7 years after treatment for Ewing sarcoma of the left pelvis. She did not receive radiation therapy. Following the recent developing multidisciplinary therapy, long-term follow-up for monitoring latent treatment-related adverse effects may be necessary for survivors of primary malignant bone tumors.

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Ewing Sarcoma with 7;22 Translocation: Three New Cases and Clinicopathological Characterization

Shulman

Katzenstein

Bridge³

et al. 2012

Fetal and Pediatric Pathology

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Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90%), ERG1 (5%), ETV1 (1%), ETV4 (1%), and FEV (1%). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.

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Sequential Ewing's sarcoma and osteosarcoma

Cited by 3 publications

References 21 publications

Long-Term Follow-Up of Adamantinoma of the Tibia Complicated by Metastases and a Second Unrelated Primary Cancer: A Case Report and Literature Review

Long-Term Follow-Up of Adamantinoma of the Tibia Complicated by Metastases and a Second Unrelated Primary Cancer: A Case Report and Literature Review

Diagnosis of osteosarcoma in a patient previously treated for Ewing sarcoma

Ewing Sarcoma with 7;22 Translocation: Three New Cases and Clinicopathological Characterization

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