2005
DOI: 10.1109/tbme.2005.845212
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Sequential Finite Element Model of Tissue Electropermeabilization

Abstract: Abstract-Permeabilization, when observed on a tissue level, is a dynamic process resulting from changes in membrane permeability when exposing biological cells to external electric field (E).In this paper we present a sequential finite element model of E distribution in tissue which considers local changes in tissue conductivity due to permeabilization. These changes affect the pattern of the field distribution during the high voltage pulse application.The presented model consists of a sequence of static model… Show more

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Cited by 244 publications
(207 citation statements)
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“…DC conductivity at low electric field magnitudes (σ 0 = 0.08 S/m) and DC conductivity at very high fields (σ MAX = 0.31 S/m = σ 0 + Δσ) were obtained from [15]. The sigmoid behavior and the parameters that determine its shape were adjusted from data in [18]. Gompertz sigmoid function was chosen instead of other possible sigmoid functions, such as the sigmoid expression employed in [18], because its shape parameters are easily identifiable in the expression.…”
Section: Theoretical Model: Ep Problemmentioning
confidence: 99%
See 1 more Smart Citation
“…DC conductivity at low electric field magnitudes (σ 0 = 0.08 S/m) and DC conductivity at very high fields (σ MAX = 0.31 S/m = σ 0 + Δσ) were obtained from [15]. The sigmoid behavior and the parameters that determine its shape were adjusted from data in [18]. Gompertz sigmoid function was chosen instead of other possible sigmoid functions, such as the sigmoid expression employed in [18], because its shape parameters are easily identifiable in the expression.…”
Section: Theoretical Model: Ep Problemmentioning
confidence: 99%
“…The sigmoid behavior and the parameters that determine its shape were adjusted from data in [18]. Gompertz sigmoid function was chosen instead of other possible sigmoid functions, such as the sigmoid expression employed in [18], because its shape parameters are easily identifiable in the expression.…”
Section: Theoretical Model: Ep Problemmentioning
confidence: 99%
“…One is the increase in tissue conductivity (σ) due to increased electric field (E) causing cell membrane electroporation (Pliquett and Weaver, 1996;Pavselj et al, 2005;Sel et al, 2005). This change of material properties has two more nonlinear characteristics.…”
Section: Biological Tissuesmentioning
confidence: 99%
“…When using cell electroporation in clinics, e.g., for tumor and gene therapy, it is important to know in advance whether and how many of cells will become electroporated as a result of a particular electric treatment. This could be achieved by using theoretical models of electroporation [2], optimized by using real experimental data on cell electroporation [3,4].…”
Section: Introductionmentioning
confidence: 99%