Sequential injection redox or acid–base titration for determination of ascorbic acid or acetic acid

Lenghor, Narong; Jakmunee, Jaroon; Vilen, Michael; Sara, Rolf; Christian, Gary D.; Grudpan, Kate

doi:10.1016/s0039-9140(02)00444-7

Cited by 58 publications

(19 citation statements)

References 10 publications

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“…In comparison with the previously reported flow approaches (Kukoc-Modun et al, 2012;Lenghor et al, 2002;Molina-Diaz et al, 1998;Oliveira & Masini, 2001;Tesfaldet et al, 2004;Udnana et al, 2004) the flow system based on sandwich technique has been proposed for the simultaneous separate determination of iron (II) and ascorbic acid in antianemic pharmaceuticals for the first time. Taking into account high content of analytes (13-20%) in the pharmaceuticals the LOD values of the developed approach are quite satisfactory.…”

Section: Resultsmentioning

confidence: 99%

“…For the determination of iron (II) and ascorbic acid in pharmaceuticals the flow injection (Alonso, Bartrolí, del Valle, & Barber, 1989;Alonso, Bartroli, Delvalle, Escalada, & Barber, 1987;Alonso-Chamarro, Bartroli, & Barber, 1992;Araujo, Lima, Alonso-Chamarro, Bartroli, & Poch, 1991;Cerda & Cerda, 2009;Falkova, Pushina, Bulatov, Alekseeva, & Moskvin, 2014;Horstkotte & Cerdà, 2009;ISO 5725-1, 1994; IUPAC, 1997; Kukoc-Modun, Biocic, & Radic, 2012;Lenghor et al, 2002;Mervartova et al, 2007;Molina-Diaz, Ortega-Carmona, & Pascual-Reguera, 1998;Mortatti, Krug, Pessenda, & Zagatto, 1982;Ruzicka & Hansen, 1975;Ruzicka & Marshall, 1990;Tzanavaras & Themelis, 2007;Udnana et al, 2004) and sequential injection (Lenghor et al, 2002;Oliveira & Masini, 2001;Tesfaldet, van Staden, & Stefan, 2004) techniques were developed, which provide high sensitivity (Table 1) ). However, they are focused only on the determination of iron (II) or ascorbic acid.…”

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confidence: 99%

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Simultaneous determination of iron (II) and ascorbic acid in pharmaceuticas based on flow sandwich technique

Vakh

Freze

Pochivalov

et al. 2015

Journal of Pharmacological and Toxicological Methods

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The simple and easy performed flow system based on sandwich technique has been developed for the simultaneous separate determination of iron (II) and ascorbic acid in pharmaceuticals. The implementation of sandwich technique assumed the injection of sample solution between two selective reagents and allowed the carrying out in reaction coil two chemical reactions simultaneously: iron (II) with 1,10-phenanthroline and ascorbic acid with sodium 2,6-dichlorophenolindophenol. For achieving of excellent repeatability and considerable reagent saving the various parameters such as flow rate, sample and reagent volumes, reaction coil length were also optimized. The limits of detection (LODs) obtained by using the developed flow sandwich-type approach were 0.2 mg L .

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Simultaneous determination of iron (II) and ascorbic acid in pharmaceuticas based on flow sandwich technique

Vakh

Freze

Pochivalov

et al. 2015

Journal of Pharmacological and Toxicological Methods

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“…For this purpose, a wide variety of methods are presented in literature. Methods based on spectrophotometric readings of UV [3][4][5] and Vis [6][7][8][9][10][11][12][13] radiations, fluorimetric [14][15][16][17][18][19][20][21] and HPLC [22][23][24][25][26][27][28][29][30][31][32] are frequently reported. They regard optical and separative techniques, and may require more or less sophisticated equipment and extensive sample preparation procedures.…”

Section: Introductionmentioning

confidence: 99%

Keywords Index

Sales¹,

Castanheira²,

Ferreira³

et al. 2007

Port. Electrochim. Acta

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Simple, rapid and precise amperometric methods for quantification of ascorbic acid (AA) are presented. Glassy carbon (GC), carbon paste (CP) and modified carbon paste (MCP) electrodes are used for this purpose. MCP electrodes are of CP with 10 % vanadate (V). All electrodes are inserted in a wall-jet device with an Ag/AgCl reference electrode and a platinum auxiliary electrode. This device is coupled to a flow injection analysis (FIA) set-up. Hydrodynamic and amperometric parameters are optimized unvaryingly. GC electrodes present slopes of 4.75 × 10 5 nA L mol -1 (± 6.4 %) under optimum conditions. CP and MCP electrodes show higher sensitivity, with slopes of 6.37 × 10 5 nA L mol -1 (± 6.6 %) and 7.32 × 10 5 nA L mol -1 (± 4.4 %). Linear responses range (1.0-2.0) × 10 -6 to (0.8-1.0) × 10 -5 mol L -1 . Correlation coefficients were > 0.994 and about 48 samples are analysed per hour. Application of the proposed method to the analysis of soft drinks is presented.

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“…Numerous analytical procedures have been developed, including spectrometry [9], fluorimetry [10], enzymatic methods [11], chromatography [12], titrimetry [13,14], chemiluminescence [15], spectrophotometry [16,17,18], calorimetry [19], oscillator reaction method [20], optical sensor [21], and thermal analysis [22]. Each technique has its advantages and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Carbon paste electrode modified with copper(II) phosphate immobilized in a polyester resin for voltammetric determination of l -ascorbic acid in pharmaceutical formulations

et al. 2003

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A carbon paste electrode modified with copper(II) phosphate immobilized in a polyester resin (CuP-Poly) is proposed for voltammetric determination of L-ascorbic acid in pharmaceutical formulations. The modified electrode allows the detection of L-ascorbic acid at lower anodic potentials than observed at unmodified electrodes. Several parameters that can influence the voltammetric response of the proposed electrode such as carbon paste composition, pH, scan rate, and possible interference were investigated. The peak current was proportional to the concentration of ascorbic acid in the range 2.0 x 10(-5) to 3.2 x 10(-3) mol L(-1) with a detection limit of 1.0 x 10(-5) mol L(-1). The stability and repeatability of the electrode for the determination of L-ascorbic acid are also discussed. Amperometric response was also recorded for electrocatalytic oxidation of the L-ascorbic acid. Concentrations of the vitamin C in pharmaceutical formulations (tablets) measured using the modified electrode and a titrimetric method are in agreement at the 95% confidence level and within an acceptable range of error.

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Sequential injection redox or acid–base titration for determination of ascorbic acid or acetic acid

Cited by 58 publications

References 10 publications

Simultaneous determination of iron (II) and ascorbic acid in pharmaceuticas based on flow sandwich technique

Simultaneous determination of iron (II) and ascorbic acid in pharmaceuticas based on flow sandwich technique

Keywords Index

Carbon paste electrode modified with copper(II) phosphate immobilized in a polyester resin for voltammetric determination of l -ascorbic acid in pharmaceutical formulations

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