Sequential nailfold videocapillaroscopy examinations have responsiveness to detect organ progression in systemic sclerosis

Avouac, Jérôme; Lepri, Gemma; Smith, Vanessa; Toniolo, E.; Hurabielle, Charlotte; Vallet, A.; Amrouche, Fazia; Kahan, André; Cutolo, Maurizio; Allanore, Yannick

doi:10.1016/j.semarthrit.2017.02.006

Cited by 82 publications

(95 citation statements)

References 39 publications

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“…Laboratory biomarkers were not included in the study. Moreover, in a prospective study of Avouac et al [15] evaluating NVC in patients with SSc, loss of capillaries over time was an independent marker of overall disease progression (HR = 4.35) and occurrence of new DU (HR = 5.33).…”

Section: Discussionmentioning

confidence: 97%

“…For the assessment of the score of capillary loss, the normal range of 9 capillaries/mm was adopted [13,14,26]. To calculate the mean score of capillary loss, a semiquantitative rating scale (0 = no changes; 1 = < 33% of capillary reduction; 2 = 33-66% of capillary reduction; 3 = > 66% of capillary reduction per linear mm) was adopted according to previous studies [13][14][15]. The participants were also classified according to two patterns found: normal or SD pattern.…”

Section: Nailfold Videocapillaroscopy (Nvc)mentioning

confidence: 99%

“…Several factors, including SSc-related autoantibodies, nailfold capillaroscopy abnormalities and endothelial activation biomarkers, have been associated with DUs in patients with SSc [12][13][14][15][16][17]. In particular, capillaroscopy, a noninvasive toll to assess the structural digital microvasculopathy, has been associated with an increase in DUs development in several studies [13,16].…”

Section: Introductionmentioning

confidence: 99%

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Risk of digital ulcers occurrence in systemic sclerosis: a cross-sectional study

et al. 2019

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Background/objective: Digital ulcers (DUs) represent a frequent complication of systemic sclerosis (SSc). The aim of this study was to evaluate clinical, serological and capillaroscopy features that are associated with DUs in patients with SSc. Methods: In this bicentric cross-sectional study, 70 patients with SSc were consecutively selected from March 2016 to April 2017. Demographic and clinical features, including the presence of active DUs, were collected. Videocapillaroscopy was performed in all patients. Results: Among the 70 patients included (mean age of 46.8 years, mean disease duration of 9.41 years), 14 (20%) had active DUs. Based on multivariate analysis, the presence of anti-Scl-70 antibodies, the HAQ-DI score, and the capillary loss score were independently associated with DUs with odds ratios of 7.96 (95% CI 1.32-47.99), 55.77 (95% CI 1.76-1764.28), and 16.66 (95% CI 2.07-133.81), respectively. Conclusions: The presence of avascular areas in capillaroscopy, elevation of HAQ-DI score and anti-Scl-70 antibodies were independent factors associated with DUs in patients with SSc.

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Section: Discussionmentioning

confidence: 97%

Section: Nailfold Videocapillaroscopy (Nvc)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk of digital ulcers occurrence in systemic sclerosis: a cross-sectional study

et al. 2019

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“…However, most of the other studies contain retrospective bias that cannot be ignored, and it is difficult to say whether NVC abnormality can predict future organ involvement. One prospective study has indicated the possibility of prognostic prediction by NVC findings [28], and prospective trials in a multicenter collaboration are desired in the future.…”

Section: Correlation Between Patterns Of Nvc Scleroderma Spectrum Abnmentioning

confidence: 99%

The role of nailfold videocapillaroscopy in patients with systemic sclerosis

Kubo

Smith

Cutolo

et al. 2018

Immunological Medicine

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“…In a prospective study, Koenig et al observed that 79% of patients with RP and a scleroderma pattern on NFC and SSc‐specific autoantibodies developed definite SSc over a 20‐year follow‐up . Moreover, progressive microvascular changes as assessed by capillaroscopy have been described in patients with established disease …”

Section: Introductionmentioning

confidence: 99%

Capillaroscopy changes are associated with disease progression in patients with early systemic sclerosis: A prospective study

Camargo

Kayser

2019

Int J of Rheum Dis

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Aim: After the development of the 2013 American College of Rheumatology (ACR)/ European League Against Rheumatism (EULAR) classification criteria for systemic sclerosis (SSc), there are still a group of patients affected by early SSc who do not meet the new criteria. This study aimed to evaluate capillaroscopy changes and to identify predictors of progression to definite SSc in patients with early SSc over a 3-year follow-up. Methods: In this prospective study, 44 patients with early SSc (LeRoy and Medsger 2001 criteria) were included. Clinical evaluation and widefield nailfold capillaroscopy were performed at baseline and after 3 years of follow-up. At the end of follow-up, the fulfilment of the 2013 ACR/EULAR criteria was also assessed. Results: After 3 years, 34 patients with early SSc were re-evaluated. Of these, eight patients (23.5%) developed definite SSc. Worsening of capillaroscopy parameters was observed in 55.9% of patients. An increase in the number of giant capillaries andworsening of the avascular score were more frequent in patients who developed SSc than in those who did not (P = 0.02; P = 0.002, respectively). By multivariate analysis, an active or a late pattern at baseline on capillaroscopy was an independent predictor for the development of definite SSc (odds ratio = 30.0, 95% CI 2.1-421.

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Sequential nailfold videocapillaroscopy examinations have responsiveness to detect organ progression in systemic sclerosis

Cited by 82 publications

References 39 publications

Risk of digital ulcers occurrence in systemic sclerosis: a cross-sectional study

Risk of digital ulcers occurrence in systemic sclerosis: a cross-sectional study

The role of nailfold videocapillaroscopy in patients with systemic sclerosis

Capillaroscopy changes are associated with disease progression in patients with early systemic sclerosis: A prospective study

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