Sequential Prospective Analysis of the Nonspecific Host Defense System After Thermal Injury

Deitch, Edwin A.; Gelder, Frank B.; McDonald, John C.

doi:10.1001/archsurg.1984.01390130065012

Cited by 26 publications

(3 citation statements)

References 20 publications

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“…In contrast, weak priming may result in an enhanced PMN bactericidal capacity [16]. In our experiments, excessive phagocy tosis of S', aureus did not result, as antici pated, in increased bacterial killing but rather in decreased killing, a fact that has previously been shown [17], This decrease may be criti cal as the addition of normal PMN to low inoculum Pseudomonas aeruginosa increased the tissue damage in an in vitro model of pul monary epithelium. PMN depletion and ROR inhibition may abolish or delay bacteria-induced tissue damage [4,18,19].…”

Section: Discussionsupporting

confidence: 64%

Effect of Allogeneic Polymorphonuclear Neutrophils on Staphylococcal Sepsis in Mice

Belotsky¹,

Diamantstein²,

Rubinstein³

1995

Eur Surg Res

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The antibacterial and host-damaging properties of locally injected allogeneic polymorphonuclear neutrophils (PMN) were studied in vivo. Peritoneal PMN were obtained from donor mice 24 h after i.m. infection with sublethal (SD) and lethal (LD) dose of Staphylococcus aureus. These donor PMN were mixed with S. aureus and injected i.m. into normal recipient mice. Normal donor PMN and PMN obtained from SL-infected donor mice did not induce the mortality of SL-infected recipient mice but protected LD-infected recipients (5.8% mortality vs. 29.4%). PMN obtained from LD-infected donor mice caused ca. 77% mortality in SD-infected recipients. In survivors, during the first 3 h infection, serum tumor necrosis factor (TNF) concentrations were higher than those in nonsurvivors and then decreased. In contrast, TNF level in nonsurvivors continued to be increased until death. PMN from LD-infected donors had the highest spontaneous chemi-luminescence response (CL), the shortest time of peak and the lowest level of intracellular CL against S. aureus. These donor PMN exhibited increased phagocytosis and decreased killing of S. aureus than that of PMN of SD-infected donor mice. Early stimulation of PMN functions such as bacterial internalization and respiratory burst may result in decrease of their tissue-damaging properties.

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Section: Discussionsupporting

confidence: 64%

Effect of Allogeneic Polymorphonuclear Neutrophils on Staphylococcal Sepsis in Mice

Belotsky¹,

Diamantstein²,

Rubinstein³

1995

Eur Surg Res

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“…In clinical studies, declines in pFn levels were observed for 1-2 days after surgery, trauma, burns, and infec tion, with subsequent restoration and a rise in the levels to such degrees that they exceeded the initial values after 3-5 days. Thereafter, the pFn levels returned to initial levels within 7-14 days [14,23,24].…”

Section: Discussionmentioning

confidence: 99%

Recombinant Interleukin-1 Triggers the Increase of Circulating Fibronectin Level in Rats

Hagiwara

Kono²,

Nemoto³

et al. 1989

Int Arch Allergy Immunol

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Interleukin-1 (IL-1) is one of the mediators responsible for the acute phase protein response during inflammation. We evaluated the effect of recombinant IL-1α given intra-abdominally on rat circulating fibronectin (Fn) level. Circulating Fn level, sampled between 3 h and 7 days after injection, was maximum at 24–48 h in Wistar rats treated with IL-1 at doses of 10 U and 100 U/100 g body weight (BW), respectively. Circulating Fn level in rats injected with 100 U/100 g BW IL-1 was higher than that of rats given 10 U/100 g BW IL-1. Circulating Fn level peaked at 24 h, whereas albumin levels decreased by 10% at this time. When frozen tissue sections of rat liver were examined using anti-Fn antibodies, the immuno stainings were denser in IL-1 -treated animals than in controls. These findings suggest that IL-1 triggers plasma Fn production by the liver.

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“…3 Leukocytes at a final concentration of 5 106/mL were incubated with 106 S aureus or aeruginosa in minimal essential medium supplemented with either control serum or blister fluid (10%, v/v). The leukocyte-bacterial suspension was incubated at 37°C on a rotating shaker.…”

Section: Phagocytic and Killing Assaymentioning

confidence: 99%

Failure of Local Immunity

Deitch¹

1985

Arch Surg

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Sequential Prospective Analysis of the Nonspecific Host Defense System After Thermal Injury

Cited by 26 publications

References 20 publications

Effect of Allogeneic Polymorphonuclear Neutrophils on Staphylococcal Sepsis in Mice

Effect of Allogeneic Polymorphonuclear Neutrophils on Staphylococcal Sepsis in Mice

Recombinant Interleukin-1 Triggers the Increase of Circulating Fibronectin Level in Rats

Failure of Local Immunity

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