Sequential release kinetics of two (gentamicin and BMP-2) or three (gentamicin, IGF-I and BMP-2) substances from a one-component polymeric coating on implants

Strobel, Catrin; Bormann, Nicole; Kadow-Romacker, Anke; Schmidmaier, Gerhard; Wildemann, Britt

doi:10.1016/j.jconrel.2011.07.006

Cited by 77 publications

(72 citation statements)

References 70 publications

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“…The sequence of delivery of BMP-2 (300 ng/mL) and FGF-2 (2.5 ng/mL) also provided relevant data, and it was observed that the release of FGF-2 followed by BMP-2 or the delivery of BMP-2 followed by the simultaneous delivery of FGF-2 and BMP-2 enhanced osteogenic differentiation more significantly than the simultaneous delivery of both factors. 178 Strobel et al 179 applied a multiple and sequential delivery coating, promoting the release of gentamicin, IGF-1, and BMP-2. The earlier action of IGF-1 promoted cell proliferation, while BMP-2 stimulated alkaline phosphatase (ALP) activity.…”

Section: From Single To Multiple Bioactive Factor Delivery For Skeletmentioning

confidence: 99%

Controlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering—Part II: Challenges on the Evolution from Single to Multiple Bioactive Factor Delivery

Santo

Gomes²,

Mano³

et al. 2013

Tissue Engineering Part B: Reviews

105

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The development of controlled release systems for the regeneration of bone, cartilage, and osteochondral interface is one of the hot topics in the field of tissue engineering and regenerative medicine. However, the majority of the developed systems consider only the release of a single growth factor, which is a limiting step for the success of the therapy. More recent studies have been focused on the design and tailoring of appropriate combinations of bioactive factors to match the desired goals regarding tissue regeneration. In fact, considering the complexity of extracellular matrix and the diversity of growth factors and cytokines involved in each biological response, it is expected that an appropriate combination of bioactive factors could lead to more successful outcomes in tissue regeneration. In this review, the evolution on the development of dual and multiple bioactive factor release systems for bone, cartilage, and osteochondral interface is overviewed, specifically the relevance of parameters such as dosage and spatiotemporal distribution of bioactive factors. A comprehensive collection of studies focused on the delivery of bioactive factors is also presented while highlighting the increasing impact of platelet-rich plasma as an autologous source of multiple growth factors.

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Section: From Single To Multiple Bioactive Factor Delivery For Skeletmentioning

confidence: 99%

Controlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering—Part II: Challenges on the Evolution from Single to Multiple Bioactive Factor Delivery

Santo

Gomes²,

Mano³

et al. 2013

Tissue Engineering Part B: Reviews

105

View full text Add to dashboard Cite

show abstract

“…Strobel et al [19] recently coated a titanium Kirschner wire implant with multiple layers of poly(D,L-lactide) in order to control the delivery of an antibiotic (gentamycin), and two GFs (insulin-like growth factor (IGF-1) and BMP-2) to prevent infection and stimulate bone healing respectively. In the presence of the antibiotic, both GFS acted in synergy on ALP activity and metabolic activity in human primary osteoblast-like cells after incubation for 7 days.…”

Section: New Alternativesmentioning

confidence: 99%

“…19,20). This affinity is principally based on the nature and the strength of non-covalent interactions (hydrophobic interactions, hydrogen and ionic bonds and van der Walls forces).…”

Section: Mechanistic Modelsmentioning

confidence: 99%

“…We recently developed a peptide derived from BMP-9 (pBMP-9) [16]. Some teams are even trying to design devices that deliver more than two GFs sequentially or simultaneously in order to reproduce more faithfully the chemical environment of bone cells during bone healing [17][18][19]. We will review the latest GFDSs and explore these new perspectives.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bone repair: New developments in growth factor delivery systems and their mathematical modeling

Lauzon

Bergeron

Marcos

et al. 2012

Journal of Controlled Release

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“…For example, antibiotics containing carboxyl groups were co-deposited substantially more effectively than those lacking such group. Strobel et al (2011) prepared polylactide (PLA) coatings on Ti wires for controlled surface release of various drugs, such as antibiotics and growth factors. However, PLA and related polymers are hydrophobic, lack bioactivity (osseointegration) (Radin et al, 1997;Holzwarth and Ma, 2011) and may adversely affect implant fixation.…”

Section: Introductionmentioning

confidence: 99%

Microparticle entrapment for drug release from porous-surfaced bone implants

Wang

Liu

Xiao

et al. 2015

Journal of Microencapsulation

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Metallic bone implants face interfacial concerns, such as infection and insufficient bone formation. Combination of drug-loaded microparticles with the implant surface is a promising approach to reducing the concerns. The present study reports a simple method for this purpose. Drug-loaded chitosan and alginate microparticles were separately prepared by emulsion methods. Dry microparticles were introduced into porous titanium (Ti) coatings on Ti discs, and induced to agglomerate in pores by wetting with water. Agglomerates were stably entrapped in the pores: 77-82% retained in the coating after immersion in a water bath for 7 d. Discs carrying drug-loaded microparticles showed a rapid release within 6 h and a subsequent slow release up to 1 d. After coculture with Staphylococcus epidermidis for 24 h, the discs formed inhibition zones, confirming antibacterial properties. These suggest that the microparticle entrapment-based method is a promising method for reducing some of the bone-implant interfacial concerns.

show abstract

Sequential release kinetics of two (gentamicin and BMP-2) or three (gentamicin, IGF-I and BMP-2) substances from a one-component polymeric coating on implants

Cited by 77 publications

References 70 publications

Controlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering—Part II: Challenges on the Evolution from Single to Multiple Bioactive Factor Delivery

Controlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering—Part II: Challenges on the Evolution from Single to Multiple Bioactive Factor Delivery

Bone repair: New developments in growth factor delivery systems and their mathematical modeling

Microparticle entrapment for drug release from porous-surfaced bone implants

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