Sequential separation by HDEHP of carrier-free101,105,106Rh,103,104,105,106,110,112Ag and104,105,107,109,111Cd produced in alpha-particle activated palladium

Lahiri, Susanta; Mukhopadhyay, B.; Nandy, Maitreyee; Das, Ν. R.

doi:10.1007/bf02034630

Cited by 17 publications

(6 citation statements)

References 7 publications

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“…Lahiri et al reported the production of 103 Ag, 104 Ag, 105 Ag, 106 Ag, 110 Ag and 112 Ag (along with 101 Rh, 105 Rh and 106 Rh and 104 Cd, 105 Cd, 107 Cd, 109 Cd and 111 Cd) by the α-particle irradiation of a natural palladium target in a 40 MeV cyclotron (2 μA), and their subsequent extraction and separation by using di-(2-ethylhexyl)phosphoric acid (HDEHP) as a liquid cation exchanger [ 29 ]. The activated palladium target was dissolved in 4 M HNO 3 and the solution was made ammoniacal by the addition of concentrated NH 3 followed by the addition of H 2 O 2 .…”

Section: Separation Of Silver Radioisotopesmentioning

confidence: 99%

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Lights and Shadows on the Sourcing of Silver Radioisotopes for Targeted Imaging and Therapy of Cancer: Production Routes and Separation Methods

Tosato

Asti

2023

Pharmaceuticals

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The interest in silver radioisotopes of medical appeal (silver-103, silver-104m,g and silver-111) has been recently awakened by the versatile nature of their nuclear decays, which combine emissions potentially suitable for non-invasive imaging with emissions suited for cancer treatment. However, to trigger their in vivo application, the production of silver radioisotopes in adequate amounts, and with high radionuclidic purity and molar activity, is a key prerequisite. This review examines the different production routes of silver-111, silver-103 and silver-104m,g providing a comprehensive critical overview of the separation and purification strategies developed so far. Aspects of quality (radiochemical, chemical and radionuclidic purity) are also emphasized and compared with the aim of pushing towards the future implementation of this theranostic triplet in preclinical and clinical contexts.

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Section: Separation Of Silver Radioisotopesmentioning

confidence: 99%

“…The aqueous phase was treated with an equal volume of 10% HDEHP/0.1 M citric acid solution and the silver radioisotopes, along with the bulk palladium, were completely extracted as [Pd(H 2 O) 4 ] + and [Ag(H 2 O) 2 ] + , respectively. Finally, the silver radioisotopes were stripped into 6 M HNO 3 [ 29 ].…”

Section: Separation Of Silver Radioisotopesmentioning

confidence: 99%

Lights and Shadows on the Sourcing of Silver Radioisotopes for Targeted Imaging and Therapy of Cancer: Production Routes and Separation Methods

Tosato

Asti

2023

Pharmaceuticals

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“…Therefore numbers of radionuclides of different elements were produced in single target matrix. Efficient radiochemical separation methods were developed afterwards, so that radionuclides of different elements can be put in different confinements [4][5][6][7][8][9][10]. The precious cyclotron time was saved; radionuclides of different elements were produced in a single accelerator run.…”

Section: Heavy Ion Activation Genesis Of Heavy Ion Activationmentioning

confidence: 99%

Across the energy scale: from eV to GeV

Lahiri

2015

J Radioanal Nucl Chem

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This article is an extended version of Hevesy Medal Award Lecture-2015, delivered at the Tenth International Conference on Methods and Applications of Radioanalytical Chemistry (MARC X) held at Hawai'i during 12-17 April 2015. The award was given on our works on heavy ion activation, tracer packet technique, converter targets and green chemistry. This article briefly addresses on all the four topics described above.

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“…Proton or deuteron induced reactions on silver target also produces 109 Cd [15,[21][22][23]. Lahiri et al [24,25] produced 104,105,107,109,111 Cd along with other co-produced radionuclides by bombarding a-particle on natural Pd target. Recently, we have reported simultaneous production of 111 In and 109 Cd by a-particle induced reaction on natural silver target [26].…”

Section: Introductionmentioning

confidence: 99%

Separation of no-carrier-added 111In and 109Cd from α-particle induced Ag target using glass wool surface

Lahiri

Maiti

Ghosh

2015

J Radioanal Nucl Chem

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Alpha particle bombardment on thick silver target produced no-carrier-added (NCA) 111 In and 109 Cd radioisotopes in the matrix. NCA 111 In and 109 Cd were separated from the target matrix by solid-liquid extraction using glass wool surface. At 10 -2 M HNO 3 concentration, *100 % 111 In and 93 % 109 Cd were adsorbed on the glass wool surface along with 16 % contamination of bulk Ag. After quantitative removal of bulk Ag from glass wool surface by de-ionized water, 111 In and 109 Cd were desorbed by 0.1 M HNO 3 . The mutual separation between 111 In and 109 Cd was achieved by column chromatography using Dowex 50WX-50 resin.

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Sequential separation by HDEHP of carrier-free101,105,106Rh,103,104,105,106,110,112Ag and104,105,107,109,111Cd produced in alpha-particle activated palladium

Cited by 17 publications

References 7 publications

Lights and Shadows on the Sourcing of Silver Radioisotopes for Targeted Imaging and Therapy of Cancer: Production Routes and Separation Methods

Lights and Shadows on the Sourcing of Silver Radioisotopes for Targeted Imaging and Therapy of Cancer: Production Routes and Separation Methods

Across the energy scale: from eV to GeV

Separation of no-carrier-added 111In and 109Cd from α-particle induced Ag target using glass wool surface

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