Sequentially annealed highly cross-linked polyethylene reduced in vivo wear particle generation in total knee arthroplasty

Abstract

The sequentially annealed HXLPE reduced the in vivo polyethylene wear particles by 58% compared with conventional polyethylene without the significant change of particle size and shape.

Comparable results between crosslinked polyethylene and conventional ultra-high molecular weight polyethylene implanted in total knee arthroplasty: systematic review and meta-analysis of randomised clinical trials

“…For each outcome, the analysis did not show any significant publication bias effect. No significant heterogeneity was observed in the statistical analysis results for each outcome analysed in the included studies [ 16 , 23 , 25 , 26 , 29 , 42 ]. There was no statistically significant difference found regarding the superiority of HXLPE over CPE for all outcomes assessed above ( p > 0.05) (Figs.…”

“…Kindsfater et al [ 26 ] observed similar Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) [ 13 ] values in the postoperative period between the two types of liners compared. Minoda et al [ 42 ] did not find a benefit in the use of HXLPE over CPE in either range of motion (ROM) or University of California Los Angeles (UCLA) activity score [ 45 ] in the postoperative period. Lachiewicz et al [ 29 ], in their study, found similar results comparing the lower extremity activity score (LEAS) [ 55 ] in the two polyethylene groups.…”

“…This meta-analysis presents limitations that need to be considered. These were mainly related to the limited number of included studies; Minoda et al [ 42 ] and Hinarejos et al [ 16 ] had small sample sizes that could provide a lower statistical analysis. Additional clinical studies with larger samples of patients will be necessary to further evaluate the superiority of HXLPE over CPE in TKA.…”

“…After exclusion of duplicates, 1989 studies were included, of these, 1976 were excluded after examining the title and abstract. After the full-text evaluation for eligibility of these 13 studies, according to the inclusion and exclusion criteria, 6 clinical studies [ 16 , 23 , 25 , 26 , 29 , 42 ] that evaluated differences in clinical and radiological outcomes using HXLPE versus CPE in TKA were included in the analysis. The bibliography for each article was reviewed to find additional relevant publications.…”

Massive Osteolysis in a Modern Total Knee Prosthesis

“…Meneghini et al [ 11 ] reported no radiographic osteolysis or mechanical failure of the tibial polyethylene at 5-year follow-up. Minoda et al [ 12 ] showed a 58% reduction of the number of in vivo X3® wear particles compared to conventional PE in TKA.…”