Seremban Cohort Study (SECOST): a prospective study of determinants and pregnancy outcomes of maternal glycaemia in Malaysia

Abstract

IntroductionBoth gestational diabetes mellitus (GDM) and hyperglycaemia less severe than GDM are associated with risk of adverse pregnancy outcomes. We describe the study design of a prospective cohort of pregnant women recruited in early pregnancy with follow-ups of mothers and infants up to 2 years after birth. The primary aim of the study was to identify the determinants and outcomes of maternal glycaemia.Methods and analysisSeremban Cohort Study (SECOST) is an ongoing prospective cohort study in which eligible pregnant women in first trimester (<10 weeks of gestation) are recruited from Maternal and Child Health clinics in Seremban District, Negeri Sembilan with seven follow-ups during pregnancy through 2 years postnatally. Infants are followed up every 6 months after birth until 2 years old. A standard 75 g oral glucose tolerance test is performed between 24 and 32 of weeks of gestation and as close to 28 weeks of gestation. Pregnancy and birth information are obtained from medical records. Sociodemographic, anthropometric, biochemical, dietary, physical activity, smoking, depression, child feeding and other data of mothers and infants are obtained at follow-ups.Ethics and disseminationThis study is approved by the Medical Research Ethics Committee (MREC), Universiti Putra Malaysia (UPM/FPSK/100-9/2-MJKEtika) and MREC, Ministry of Health Malaysia (KKM/NIHSEC/08/0804/P12- 613). Permission to conduct this study is also obtained from the Head of Seremban District Health Office. All participants are required to provide written informed consent prior to data collection. The research findings will be disseminated at journals and conference presentations.

Pre-Pregnancy BMI Influences the Association of Dietary Quality and Gestational Weight Gain: The SECOST Study

“…All women were interviewed by trained enumerators using a pre-tested questionnaire. Details of the instrument have been published elsewhere [29]. The instruments were pre-tested prior to data collection as to ensure the appropriateness, clarify and interpretation of the instruments.…”

Associations between the dietary patterns of pregnant Malaysian women and ethnicity, education, and early pregnancy waist circumference: A prospective cohort study

“…This study was performed using data from the Seremban Cohort Study (SECOST). The methodology of this study has been previously described in detail (http://dx.doi.org/10.1136/bmjopen-2017-018321) [34]. In brief, SECOST is an on-going prospective cohort study in which eligible pregnant women in the first trimester (< 10 th weeks of gestation) of pregnancy are recruited from three Maternal and Child Health (MCH) clinics in Seremban District, Negeri Sembilan and then followed-up for more than two years postnatally.…”

The association between dietary patterns before and in early pregnancy and the risk of gestational diabetes mellitus (GDM): Data from the Malaysian SECOST cohort

“…Women in the first trimester (8 -10 th weeks of gestation) of pregnancy were recruited from three maternal and child health (MCH) clinics in Seremban District, Negeri Sembilan, Malaysia. Detailed descriptions of the study methodology have been previously published [39], and only a brief overview is provided here. All pregnant women were eligible to participate unless they had one or more exclusion criteria as published previously.…”