Serial Retinal Nerve Fiber Layer Changes in Patients With Toxic Optic Neuropathy Associated With Antituberculosis Pharmacotherapy

Kim, Yong-Kyu; Hwang, Jeong‐Min

doi:10.1089/jop.2009.0064

Cited by 29 publications

(15 citation statements)

References 10 publications

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“…In the TNON group, MD decrease (MD values are positive with Octopus perimetry) correlated with VA increase and time of disease progression, which corroborates what has been reported in the literature (8,12). With greater time of disease, there was a decrease in the thickness and volume of RGL, which, in conjunction to MD decrease and VA increase, raises questions about the functionality of the ganglion cells in the acute phase and at the end of toxic exposure.…”

Section: Discussionsupporting

confidence: 88%

Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy

Vieira

Silva

Santos

et al. 2015

Journal of Neuro-Ophthalmology

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Section: Discussionsupporting

confidence: 88%

Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy

Vieira

Silva

Santos

et al. 2015

Journal of Neuro-Ophthalmology

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“…papillomacular fibers [22,23]. Like glaucoma, RNFL thinning occurs, but temporal fibers are involved first in toxic/nutritional optic neuropathy.…”

Section: Key Pointsmentioning

confidence: 99%

Neuro-ophthalmic disease and optical coherence tomography: glaucoma look-alikes

Pasol

2011

Current Opinion in Ophthalmology

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OCT is a valuable tool in evaluating the peripapillary RNFL in both glaucomatous and nonglaucomatous optic neuropathies. This technology may be used for both research and clinical purposes to assess disease progression in optic neuropathies and diseases that affect the central nervous system. OCT-measured RNFL thickness remains complimentary to the clinical examination skills in the evaluation of nonglaucomatous optic neuropathies.

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“…Those studies revealed RNFL thinning in patients diagnosed with EON. 10,14,15 This condition is assumed to happen due to damage in retinal ganglion cells in the disease. Cross-sectional data of RNFL thickness is considered not sufficient in making conclusion of RNFL thinning among patients with EON, due to the highly variable baseline RNFL thickness.…”

Section: 4mentioning

confidence: 99%

Correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutol

et al. 2015

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ABSTRAK (147 dan 141 μm, p = 0,001), nasal (92 dan 88 μm, p = 0,045), dan rerata seluruh kuadran (116,77 dan 112,65 μm, p = 0,001). Tidak terdapat hubungan antara perubahan ketebalan retina ini dengan perubahan fungsi penglihatan. Kesimpulan: Konsumsi etambutol selama dua bulan dalam dosis yang dianjurkan dianggap masih aman terhadap retina manusia dan terhadap fungsi penglihatan. ABSTRACTBackground: Recent animal studies revealed the decreased amount of retinal ganglion cells after treatment with ethambutol. The aim of this study was to evaluate the changes of peripapillary retinal nerve fiber layer (RNFL) thickness in patients receiving ethambutol therapy, as well as to know the correlation of RNFL thickness changes with the changes of visual function. Methods:This was a cohort study on 29 subjects at one tuberculosis treatment center, Jakarta. Subjects underwent RNFL thickness measurement using optical coherence tomography (OCT) and several visual function parameters (visual acuity, contrast sensitivity, color sensitivity and visual field) before and two-months following ethambutol therapy. Statistical comparison between pre-and postethambutol measurements were done using either paired T-test or Wilcoxon test. Correlations between anatomical and functional changes were assessed with Spearman correlation test.Results: There were significant changes of peripapillary RNFL thickness in superior (147 and 141 μm, p = 0.001), nasal (92 and 88 μm, p = 0.045) quadrants and average RNFL thickness (116.77 and 112.65 μm, p = 0.001). No significant correlation between RNFL thickness changes and the changes of visual function parameters (p > 0.05). Conclusion:Ethambutol consumption for two months in recommended dose is still considered safe to human retina and visual status.

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Serial Retinal Nerve Fiber Layer Changes in Patients With Toxic Optic Neuropathy Associated With Antituberculosis Pharmacotherapy

Abstract: RNFL changes may not be obvious at initial presentation, but became manifest in 2 of the 5 patients over time. OCT may not be useful in identifying the RNFL defect in the early stage, but may be helpful for the follow up of the patients with TON.

Cited by 29 publications

References 10 publications

Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy

Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy

Neuro-ophthalmic disease and optical coherence tomography: glaucoma look-alikes

Correlation between peripapillary retinal nerve fiber layer thickness and visual function changes in patients receiving ethambutol

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