Serially Coupled Capillary Columns Supercritical Fluid Chromatography with a Coupling Restrictor

Hirata, Yukio; Imamura, Etsuro; Yazawa, Yoshifumi

doi:10.2116/analsci.19.727

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Low-viscosity mobile phases also provide the opportunity to use longer columns than in conventional HPLC or to couple columns. Hirata et al studied the coupling of capillary columns with dissimilar stationary phases, with and without a coupling restrictor (48). They were able to tune the influence of the second column to the first and tune the overall selectivity according to the resistance of the coupling restrictor.…”

Section: Instrumentation Techniques and Performancementioning

confidence: 99%

Supercritical Fluid and Unified Chromatography

Chester

Pinkston

2004

Anal. Chem.

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Review ContentsTheory and Fundamental Measurements 4606 Mobile Phases and (Achiral) Stationary Phases 4607 Instrumentation, Techniques, and Performance 4609 Preparative Separations 4609 Detection 4609 Applications 4610 Food-Related Applications 4610 Natural Products 4610 Fossil Fuels 4610 Synthetic Oligomers, Polymers, and Polymer Additives 4610 Achiral Pharmaceuticals and Bioactive Compounds 4611 Chiral Applications 4611 Literature Cited 4612Supercritical fluid chromatography (SFC) and related unified chromatography techniques using compressible, solvating fluids and conventional liquids at high or ultrahigh temperatures continue to grow in use. However, continuing the trend in recent years, there has been a further decrease in fundamental work and in the number of published research articles.Despite this, interest among end users continues to grow, particularly in pharmaceutical applications. Pharmaceutical researchers also continue to lead in publishing applications, perhaps reflecting the higher importance placed on publication in this business than in most others.During this review period, one analytical instrument supplier (for whom SFC was a minor product area) left the business, but another supplier, one fully dedicated to this field, enthusiastically joined. Growth also continues in the preparative SFC area and in materials processing using supercritical and related fluids, and this is expected to continue stimulating analytical applications.As in the past, we have made a very loose interpretation of the term "supercritical" for the purposes of selecting articles to cite (and in keeping with the underlying unified chromatography theme) and have included any solvating fluid that is used in either condensed or supercritical form at a temperature above its normal vaporization temperature or above the usual temperature range of conventional HPLC. We resume from our last report (1) and have examined the literature abstracted in the ISI Current Contents Connect (http://isicc.com/CCC.cgi) database through November, 2003. We found about 200 articles from which we have cited a fraction, representative of recent progress. THEORY AND FUNDAMENTAL MEASUREMENTSSeveral general reviews appeared that may be useful to people new to the field (2-4). Dominguez et al. presented a revision of the 1993 IUPAC Nomenclature for Chromatography that addresses hold-up volume and the physical meaning of several terms (5). The measurement and meaning of hold-up times and volumes as well as derived parameters, such as solute retention factor in an SFC instrument or other chromatographic system in which the mobile phase is compressible, solvent strength changes with mobile-phase density, and pressure and temperature change longitudinally along the column, will require some additional attention.Amines have been successfully determined by SFC techniques for years, but there has been uncertainty if or when amines react with CO 2 , if the peaks actually migrating through a column under SFC conditions are the original amines or something els...

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Section: Instrumentation Techniques and Performancementioning

confidence: 99%

Supercritical Fluid and Unified Chromatography

Chester

Pinkston

2004

Anal. Chem.

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“…In addition to improve the GC column performance for better separation and resolution, technology advancement for reducing the span of the GC measurement time has also been made. In this regards, method advancement of the GC column configuration system has been reported previously [11][12][13]. This column configuration system is known as column coupling method.…”

Section: Introductionmentioning

confidence: 99%

“…This column configuration system is known as column coupling method. Practically, the column coupling method consists of two columns having different stationary phase material was connected serially and configured by locating one column precedes the others or the reverse [12]. This method can also be classified as multidimensional gas chromatography, in which the sample was subjected to multiple separation processes (two in this case) coupled on-line.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Qualitative Simultaneous Identification of Permanent and Hydrocarbon Gases by GC-TCD using Column Coupling Method

Zuas

Mulyana

2017

Fr. Ukr. J. Chem.

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The potential application of the GC-TCD using column coupling method was investigated by means of comparison with the single column method for the identification of gas mixture containing 5 permanent and 6 hydrocarbon gases. The results indicate the useful of column coupling method, relative to the single column method. In addition, the flow rate of carrier gas and column temperature on the retention time of the target components have a noticeable effect. Application of the column coupling method for qualitative identification of the targeted components in natural gas samples indicate that the method can be used for routine work in the field of natural gas measurement, since the method has proven to be able to separate both hydrocarbon and permanent gas simultaneously. All the gas components that cannot be separated in the first column were well separated in the second column, which proved that column coupling method is superior to the single column separation. _______________________________________________________________________________

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