Seroconversion Against Human Herpesvirus-6 (And Other Herpesviruses) and Clinical Illness

Kirchesch, Herbert M.; Mertens, Thomas; Burkhardt, Ulrich; Kruppenbacher, JohannesP.; Höffken, Aniane; Eggers, Hans J.

doi:10.1016/s0140-6736(88)92557-3

Cited by 46 publications

(19 citation statements)

References 7 publications

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“…Contrasting with these findings, our investigation has shown HHV-6A variant to be associated with apparently immunocompetent individuals. Of note, it has been reported that immunocompromised and immunocompetent subjects are usually associated with reactivation 28,29 and primary infections 32,45,54 , respectively, whatever variant considered. Of note, latency and later reactivation are both biological properties attributable to HHV-6A and HHV-6B variants in cells and body tissues 6,7,20,38,39 .…”

Section: Discussionmentioning

confidence: 99%

Evidence of active herpesvirus 6 (variant-A) infection in patients with lymphadenopathy in Belém, Pará, Brazil

Freitas

Linhares

2003

Rev. Inst. Med. trop. S. Paulo

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SUMMARYA total of 323 patients with lymphadenopathy were selected in Belém, Brazil, between January 1996 and December 2001, and screened for the presence of human herpesvirus-6 (HHV-6) IgM-and-IgG antibodies by enzyme-linked immunosorbent assay (ELISA). When seroprevalence is analyzed by gender, similar rates are found for female (60.6%) and male (55.7%) individuals. Seventy-seven (23.8%) patients were HHV-6-IgM-and-IgG-positive (IgM+ subgroup), with positivity rates of 29.7% and 17.7% (p = 0.0007) for female-and male individuals, respectively. Sera from a subgroup (n = 120) of these subjects, with high HHV-6 antibody levels (either IgM+ or IgG+ reactivities), were subsequently processed for the presence of HHV-6 DNA by polymerase chain reaction (PCR)/nested PCR. Active infections (IgM+ and/or IgG+ high levels specific antibodies plus detection of viral DNA) were diagnosed in 20/77 (20.0%) and 8/43 (18.6%); subgroup of the 120 individuals suspected of having HHV-6 suggestive recent infection. All (n = 28) cases of active infection were found to be associated with HHV-6 variant-A (HHV-6A), as detectable by PCR/nested PCR, using variant-specific primer that amplify regions of 195 base pairs (bp) (HHV-6A) and 423 bp (HHV-6B). Rates of HHV-6 DNA detection between female and male patients were similar (p > 0.05) in the IgM+ and IgG+ groups: 20.4% versus 35.7% and 25.0% versus 13.0%, respectively. HHV-6 DNA was detected across ≤ 5 through 41-50-year age-groups for patients whose serum samples were IgM+, with rates ranging from 7.7% (female subjects aged ≤ 5 years) to 80.0% (male, 11-20 years). Among patients whose serological status was IgG+, HHV-6 DNA was detected in ≤ 5, 6-10, 21-30 and > 50 age-groups at rates that ranged from 15.4% (male, ≤ 5 years of age) to 100.0% (female aged 11-20 years). Swelling cervical lymph nodes were the most common sign, accounting for 9 (32.0%) cases in each gender group. Among patients (n = 28) with active infection by HHV-6A variant, duration of symptoms lasted 1-5 days in 35.7% of subjects, whereas in 64.3% of them the disease lasted 6-20 days. Our data suggest that it is worth seeking for HHV-6 infection whenever a patient (infant or adult) presents with lymphadenopathy as a prominent symptom in the course of an acute febrile illness.

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Section: Discussionmentioning

confidence: 99%

Evidence of active herpesvirus 6 (variant-A) infection in patients with lymphadenopathy in Belém, Pará, Brazil

Freitas

Linhares

2003

Rev. Inst. Med. trop. S. Paulo

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“…Kirchesch and colleagues [6] have described concomitant rises of IgM antibody to HHV6 and CMV accompanying an episode of fever and rash in an adult undergoing a chronic glandular-fever like illness. Reports both of CMV reactivation and HHV6 seroconversion [7] and of HHV6 IgM recrudescence in a patient with primary EBV infection [6] indicate that the presence of IgM anti-HHV6 should be interpreted cautiously. In the two adults in this series (patients 13 and 14) we found clear evidence of the production of IgM anti-HHV6 in individuals already seropositive for IgG.…”

Section: Discussionmentioning

confidence: 99%

“…Yamanishi and colleagues [4] reported-isolation of HHV6 and concomitant seroconversion for anti-HHV6 IgG in young children with roseola infantum (exanthem subitum). In 11-2 adults HHV6 infection has been associated, provisionally, with many clinical symptoms including enlarged lymph nodes [5] and a mononucleosis-like illness [6]. There has been discussion whether adult patients showing HHV6 seroconversion do so in relation to HHV6 infection alone or whether a CMV infection elicits a response to anti-HHV6 as well as anti-CMV.…”

Section: Introductionmentioning

confidence: 99%

“…There has been discussion whether adult patients showing HHV6 seroconversion do so in relation to HHV6 infection alone or whether a CMV infection elicits a response to anti-HHV6 as well as anti-CMV. There have been two reports of concurrent CMV and HHV6 seroconversion in adults [6,7]. Others have shown the presence of IgM antibody to both CMV and HHV6 in renal and cardiac transplant patients [8].…”

Section: Introductionmentioning

confidence: 99%

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Production of IgM antibody to HHV6 in reactivation and primary infection

Fox¹,

Ward²,

Briggs³

et al. 1990

Epidemiol. Infect.

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SUMMARYThe cross-reaction of HHV6 antibody with that to the other herpesviruses was studied in 96 blood donors whose sera were tested for IgG antibody to human herpesvirus type 6 (HHV6), cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella zostervirus (VZV) and herpes simplex virus (HSV). No correlation was found between IgG antibody to HHV6 and that to any of the other herpesviruses in these individuals. Antibodies to HHV6 and CMV were measured in patients undergoing documented serological responses to HHV6. Eleven cases of primary HHV6 infection associated with roseola infantum in babies, 1 of whom suffered from gastroenteritis as well as pyrexia and rash, are reported. Three cases of HHV6 reactivation, 1 in a 3-year-old child and 2 in adults, 1 of whom simultaneously underwent a primary CMV infection are also reported. Our results suggest that indirect immunofluorescence is a specific way of measuring HHV6 antibody, that HHV6 IgG and IgM can be detected in the absence of antibody to CMV and that HHV6 IgM is present both in primary HHV6 infections and in reactivations.

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“…4 In 1988, HHV-6 was recognized as the causative agent of exanthema subitum. 5 It has also been associated with a mononucleosis-like illness, 6 chronic fatigue syndrome 7 and it has been proposed as a cofactor in AIDS. 8 HHV-6 persists in salivary and bronchial glands.…”

mentioning

confidence: 99%

Human herpesvirus 6 is an important pathogen in infectious lung disease after allogeneic bone marrow transplantation

Buchbinder

Elmaagacli

Schaefer

et al. 2000

Bone Marrow Transplant

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Summary:Two hundred and ten bronchoalveolar lavage (BAL) samples were obtained from 50 patients 10 days before and on defined days after allogeneic bone marrow transplantation (BMT). The samples were examined for human cytomegalovirus (HCMV) and human herpesvirus-6 (HHV-6) by polymerase chain reaction (PCR). Fifteen patients (30%) had a positive result for HCMV in at least one sample and 25 (50%) were positive for HHV-6 in at least one sample. Five patients developed HCMV-associated interstitial pneumonia (HCMV-IP) within 100 days after allogeneic BMT. Four of these patients were positive for both HCMV and HHV-6. Conspicuous HHV-6 positivity was detected in BAL samples obtained because of respiratory symptoms. No association was found between detection of HHV-6 and acute graft-versus-host disease. Engraftment failure or a delay in engraftment was observed in none of the 50 patients. The data from this study indicate that HHV-6 is a pathogen in HCMV-associated, as well as in non-HCMV-associated infectious lung disease after BMT. Bone Marrow Transplantation (2000) 26, 639-644.

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Seroconversion Against Human Herpesvirus-6 (And Other Herpesviruses) and Clinical Illness

Cited by 46 publications

References 7 publications

Evidence of active herpesvirus 6 (variant-A) infection in patients with lymphadenopathy in Belém, Pará, Brazil

Evidence of active herpesvirus 6 (variant-A) infection in patients with lymphadenopathy in Belém, Pará, Brazil

Production of IgM antibody to HHV6 in reactivation and primary infection

Human herpesvirus 6 is an important pathogen in infectious lung disease after allogeneic bone marrow transplantation

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