Serodominance Profile in a Dust Mite Complex Region

Abstract

<b><i>Background/Objective:</i></b> The objective of this study was to describe the molecular sensitization profile of mite allergy in an area with a high environmental exposure of house dust mites (HDM) and storage mites. <b><i>Methods:</i></b> Skin prick tests were performed with standardized extracts (DIATER, Madrid, Spain). A specific commercial molecular panel (MADx) for <i>Dermatophagoides pteronyssinus</i> (Dpt), <i>Dermatophagoides farinae</i> (Dfar), <i>Lepidoglyphus destructor</i> (Ldt), <i>Tyrophagus putrescentiae</i> (Tput), and <i>Blomia tropicalis</i> (Blot) was correlated with clinical parameters in Galician (northwestern of Spain) HDM allergic patients. <b><i>Results:</i></b> Fifty patients (60% female) met the inclusion and exclusion criteria. All of the patient’s present rhinitis (50), 28% (14) rhinitis and asthma, and 18% (9) atopic dermatitis (AD). Hundred patients had a positive prick test for Dpt, followed by Dfar (92%), Ldt and Tput (74%), and Blot (68%). More than 50% recognized specific IgE for Der p 1, Der p 2, reaching 86% in the case of Der p 23. No statistically significant differences in IgE levels were found between patients with/without asthma and those with mild or moderate-severe rhinitis. Der p 7 was higher among rhinitis patients (<i>p</i> value 0.05). AD relative risk (RR) was increased in patients sensitized to Der f 2, Der p 2, and Der p 23. Der p 10 decreases the risk to have AD (RR 0.80). <b><i>Conclusion:</i></b> The evaluation of IgE results in a comprehensive panel of allergens allows differentiation of serological reactivity profiles with their clinical expression, to perform an optimal management. Improvements in component resolved diagnosis and more research on the clinical relevance of mite allergens are needed to achieve a genuine diagnosis leading to specific immunotherapy.

Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

“…The analysis with the use of Bayesian network has confirmed the fact that the most probable sensitivity in individual patient profiles is the simultaneous sensitivity to allergens of groups 1 and 2, as well as to Der p 23. The major significance of sensitization to group 1 and 2 allergens as well as to Der p 23 in the study population is consistent with the data of other authors [29].…”

“…[35,36] According to the data presented in scientific papers, Der p 7 is associated with the development of allergic rhinitis and sensitization to Der f 2, Der p 2 and Der p 23 increases the risk of developing atopic dermatitis. At the same time, sensitization to Der p 10 reduces the risk of atopic dermatitis development [29]. Our data indicate that such effect may be connected with the absence of sensitization to group 1 and 2 allergens as well as to Der p 23 in patients whose profiles contain Der p 10 as CPD of sensitization to Der f 1, Der f 2, Der p 20 and Der p 23 increased up to 68.43% if Der p 10 was absent in the profile (Fig.…”

Mite allergen sensitization patterns in Turkish children: Age‐related changes and molecular correlations

“…to the middle and minor group of allergens, were lower than the literature. 8,22,28,36 We believe this difference may be attributed to the younger age of our study group. Conversely, the positivity ratios for Der p 10 (19.7%) also known as tropomyosin and Der p 20 (19.7%) were higher than reported in the literature.…”

“…Conversely, the positivity ratios for Der p 10 (19.7%) also known as tropomyosin and Der p 20 (19.7%) were higher than reported in the literature. 22,28 Tropomyosin, 37 an allergen found in various sources such as mites, cockroaches, shellfish, anisakis, mealworms, and fruit flies [38][39][40] has prompted inquiries into the primary sensitization source. Our study revealed that over two-thirds of tropomyosin sensitizations were selective, reducing the likelihood of mites as the primary source.…”

Der p 23 sensitization in patients with house dust mite respiratory allergy

“…Even though sIgE-array platforms have included a wide spectrum of HDM allergens (8,14), only Der p 1, Der p 2, Der p 23, and Der p 10 (tropomyosin) are currently available for the component-resolved diagnosis of HDM allergy on ImmunoCAP. Our results, using InmunoCAP in the largest sample published to date, are similar to those previously reported in terms of prevalence of sensitization (6,8,14,15,17) but we report a high rate of monosensitization to Der p 23 (6,8,(15)(16)(17)(18)20,21). The clinical relevance of Der p 23 is only partially defined, and the prevalence and relevance of the exclusive sensitization to it has received little attention so far.…”