Serologic analysis of three cases of neonatal alloimmune thrombocytopenia associated with HLA antibodies

Saito, Satoshi; Ôta, Masao; Komatsu, Yumi; Ota, Satoshi; Aoki, Shigeru; Koike, Kenichi; Tokunaga, Izumi; Tsuno, Takahisa; Tsuruta, Goro; Kubo, Tetsuo; Fukushima, Hirofumi

doi:10.1046/j.1537-2995.2003.00429.x

Cited by 49 publications

(36 citation statements)

References 39 publications

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“…In humans, MHC class I alloantibodies in individual cases of fetal/neonatal alloimmune thrombocytopenia (FNAIT) have been reported a number of times during the past decades (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). In addition to thrombocytopenia, the presence of an associated neutropenia is noticed in a few cases (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Alloantibodies against MHC Class I: A Novel Mechanism of Neonatal Pancytopenia Linked to Vaccination

Foucras

Corbière

Tasca

et al. 2011

The Journal of Immunology

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Fetal/neonatal alloimmune thrombocytopenia is a frequent disease in humans where alloantibodies against platelet Ags lead to platelet destruction and hemorrhage. Although a role in the disease for Abs against MHC has been suspected, this has not been formally demonstrated. Since 2007, a hemorrhagic syndrome due to thrombocytopenia and designated as bovine neonatal pancytopenia (BNP) has been recognized in calves in several European countries. An inactivated antiviral vaccine is strongly suspected to be involved in this syndrome because of its highly frequent use in the dams of affected calves. In this study, we show that BNP is an alloimmune disease, as we reproduced the signs by transferring serum Abs from vaccinated BNP dams into healthy neonatal calves. Ab specificity was strongly associated with the presence of allogeneic MHC class I Abs in the dams. MHC class I staining was also observed on Madin–Darby bovine kidney cells, a cell line related to the one used to produce the vaccine Ag. Our report emphatically demonstrates that alloimmunization against MHC class I is associated with a substantial risk of developing cytopenia-associated syndromes in neonates when a cell line of the same species is used to produce an inactivated vaccine injected into the mother.

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Section: Discussionmentioning

confidence: 99%

Alloantibodies against MHC Class I: A Novel Mechanism of Neonatal Pancytopenia Linked to Vaccination

Foucras

Corbière

Tasca

et al. 2011

The Journal of Immunology

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“…However, limited cases of FNAIT associated with HLA class I antibodies have been described. 11 In PTR cases, platelet specific antibodies against HPAs were detected in 4/74 cases only (5%). Anti-HPA2b (n = 1), anti-HPA-5a (n = 1), anti-HPA-5b (n = 2), anti-HPA-15b (n = 3) could also be identified.…”

Section: Resultsmentioning

confidence: 94%

Platelet reactive alloantibodies responsible for immune thrombocytopenia in Malay population

Armawai¹,

Hassan²,

Wihadmadyatami

2014

Med J Indones

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Abstrak HPA1a (n = 1),Methods: Sera from suspected FNAIT (n = 295) and PTR (n = 74) were collected in five years period (2008)(2009)(2010)(2011)(2012)(2013) and tested for the presence of platelet reactive antibodies by the use of antigen capture assay. Results:In 5/74 (5.41%) platelet specific antibodies against HPA-2b (n = 1), HPA-5a (n = 1), HPA-5b (n = 1), HPA-15b (n = 2) could be identified in our PTR cohort. In FNAIT cohort, platelet specific alloantibodies could be detected in 18 sera (6.10%) consisting anti-HPA-1a (n = 1), anti-HPA-3a (n = 3), anti-HPA-5a (n = 6), anti-HPA-5b (n = 6), anti-HPA-15a (n = 1), and anti-HPA-15b (n = 1). Conclusion:Our study indicates that anti-HPA-3, -HPA-5 and -HPA-15 antibodies seems to be the most platelet specific antibodies involved in FNAIT and PTR cases in Malaysian population. Since similar HPA allelic distribution among Malaysian and Indonesian populations have been observed, immunization against these three HPA systems are expected to be the most potential risk of alloimmune mediated platelet disorders in Indonesia.Keywords: alloimmune thrombocytopenia, transfusion pISSN: 0853-1773 • eISSN: 2252-8083 • http://dx.doi.org/10.13181/mji.v23i3.1011 • Med J Indones. 201423:158-62 Correspondence author: Sentot Santoso, sentot.santoso@immunologie.med.uni-giessen.deCl i n i c a l R e s e a r c h

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“…Saito et al [2] provided serological analysis from three cases with assumed FNAITP in association with HLA antibodies. One offspring with low weight had severe respiratory distress and low Apgar scores.…”

Section: Reports On Hla Class I Incompatibilities and Fnaitp Since 2006mentioning

confidence: 99%

“…After carefully discussing the pros and cons, the author concluded that evidence that HLA antibodies may induce FNAITP is rather weak. Since this publication only three new papers have been dealing with neonatal thrombocytopenia which might be due to maternal alloantibodies with HLA class I specificity [2][3][4]. This review focuses on reports and data dealing with an association between an alloimmunization against HLA class I antigens and fetal/neonatal alloimmune thrombocytopenia (FNAITP) that have been published since 2000.…”

Section: Introductionmentioning

confidence: 99%

Controversy: HLA Antibodies Responsible for Fetal/Neonatal Alloimmune Thrombocytopenia – an Update

Panzer

2006

Transfus Med Hemother

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This review focuses on reports and data dealing with an association between an alloimmunization against HLA class I antigens and fetal/neonatal alloimmune thrombocytopenia (FNAITP) that have been published since 2000. Current serological requirements for a presumed diagnosis of FNAITP in newborns are presented to understand the hesitation towards a diagnosis of HLA antibody- associated FNAITP. Three already published case reports are extensively discussed, and data from 3 series of presumed FNAITP are presented. Furthermore, the data on light chain restriction of such HLA antibodies are discussed in view of a possible clonality of these antibodies in presumed FNAITP.

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Serologic analysis of three cases of neonatal alloimmune thrombocytopenia associated with HLA antibodies

Abstract: Transplacental passage of maternal HLA antibodies was observed in the three neonates cited in the present study.

Cited by 49 publications

References 39 publications

Alloantibodies against MHC Class I: A Novel Mechanism of Neonatal Pancytopenia Linked to Vaccination

Alloantibodies against MHC Class I: A Novel Mechanism of Neonatal Pancytopenia Linked to Vaccination

Platelet reactive alloantibodies responsible for immune thrombocytopenia in Malay population

Controversy: HLA Antibodies Responsible for Fetal/Neonatal Alloimmune Thrombocytopenia – an Update

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