Serologic and viral genome prevalence of HSV, EBV, and HCMV among healthy adults in Wuhan, China

Wen, Lei; Qiu, Yong; Cheng, Shuang; Jiang, Xuan; Ma, Yanping; Wei, Fang; Wang, Wei; Cui, Jie; Ruan, Qiang; Zhao, Fei; Hu, Fei; Luo, Min‐Hua

doi:10.1002/jmv.24989

Cited by 18 publications

(9 citation statements)

References 46 publications

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“…Our research was carried out in central China. The seroprevalence of EBV was similar to the global proportion [ 40 , 41 ], and the prevalence of hepatitis B was intermediate (5.23, 95% CI: 3.11–7.34%) [ 42 ]. Coinciding with the views of early researchers, we believe that viruses play an important role in patients with MM, especially EBV and HBV in our study.…”

Section: Discussionmentioning

confidence: 92%

Assessment of infection in newly diagnosed multiple myeloma patients: risk factors and main characteristics

et al. 2020

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Background Infection is a leading cause of morbidity and death in patients with multiple myeloma (MM). The increased susceptibility to infection is complicated and multifactorial. However, no studies have explored the spectrum and risk factors of infections in newly diagnosed MM patients at the first admission. This cross-sectional study aimed to provide ideas for the assessment, prevention and treatment of infection in newly diagnosed MM patients when admitted for the first time. Methods Retrospectively, the data from electronic medical records for 161 patients newly diagnosed with MM from May 2013 to December 2018 were analysed. All the information was collected at the time of admission, and the patients had received no antineoplastic therapy previously. Independent risk factors of infection in multiple myeloma were determined by univariate and multivariate analysis. Results Newly diagnosed patients with MM were highly susceptible to viruses (43.9%), especially Epstein-Barr virus (EBV) (24.4%) and hepatitis B virus (HBV) (17.1%). Advanced stage (ISS stage III, P = 0.040), more severe anaemia (Hb < 90 g/L, P = 0.044) and elevated CRP (> 10 mg/L, P = 0.006) were independent risk factors for infection. Moreover, infections represented a major survival threat to patients with newly diagnosed MM (P = 0.033), and the existence of risk factors for infection was significantly correlated with poor prognosis (P = 0.011), especially ISS stage III (P = 0.008) and lower haemoglobin level (P = 0.039). Conclusions Newly diagnosed MM patients are highly susceptible to viruses. Advanced ISS stage, more severe anaemia and the elevation of CRP are independent risk factors of infection, which also have a strong impact on prognosis. Our results suggest that viral infection should be taken into account if antibacterial drugs are not effective, and the prevention of infection and improvement of prognosis should be paid more attention in newly diagnosed patents with advanced stage and more severe anaemia.

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Section: Discussionmentioning

confidence: 92%

Assessment of infection in newly diagnosed multiple myeloma patients: risk factors and main characteristics

et al. 2020

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“…Sera-antibody-based epidemiological surveys show that 67% of the global population under the age of 50, equivalent to about 3.7 billion people, have been infected with HSV-1 [ 2 ]. In certain developing countries or regions, such as central and eastern China, HSV-1 seroprevalence reaches 90% [ 3 , 4 ]. Most of the HSV-1 infected population are asymptomatic, with cold sores being the most common clinical manifestation.…”

Section: Introductionmentioning

confidence: 99%

Anterograde Neuronal Circuit Tracers Derived from Herpes Simplex Virus 1: Development, Application, and Perspectives

Liu

Hong

Xiong

et al. 2020

IJMS

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Herpes simplex virus type 1 (HSV-1) has great potential to be applied as a viral tool for gene delivery or oncolysis. The broad infection tropism of HSV-1 makes it a suitable tool for targeting many different cell types, and its 150 kb double-stranded DNA genome provides great capacity for exogenous genes. Moreover, the features of neuron infection and neuron-to-neuron spread also offer special value to neuroscience. HSV-1 strain H129, with its predominant anterograde transneuronal transmission, represents one of the most promising anterograde neuronal circuit tracers to map output neuronal pathways. Decades of development have greatly expanded the H129-derived anterograde tracing toolbox, including polysynaptic and monosynaptic tracers with various fluorescent protein labeling. These tracers have been applied to neuroanatomical studies, and have contributed to revealing multiple important neuronal circuits. However, current H129-derived tracers retain intrinsic drawbacks that limit their broad application, such as yet-to-be improved labeling intensity, potential nonspecific retrograde labeling, and high toxicity. The biological complexity of HSV-1 and its insufficiently characterized virological properties have caused difficulties in its improvement and optimization as a viral tool. In this review, we focus on the current H129-derived viral tracers and highlight strategies in which future technological development can advance its use as a tool.

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“…Human cytomegalovirus (HCMV) is a ubiquitous pathogen that is highly adapted to its human host. Approximately 50 to 90% of adults are infected globally (1) and in China seroprevalence is as high as 93.7% (2). About 90% of primary HCMV infections in immunocompetent individuals are either asymptomatic or mildly symptomatic.…”

Section: Introductionmentioning

confidence: 99%

Human Cytomegalovirus Drives WDR5 to the Virion Assembly Compartment to Facilitate Virion Assembly

Yang

Yao

et al. 2020

Preprint

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We previously reported that human cytomegalovirus (HCMV) utilizes the cellular protein WDR5 to facilitate capsid nuclear egress. Here, we further show that HCMV infection drives WDR5 to the perinuclear region by a mechanism that requires viral replication and intact microtubules. WDR5 accumulated in the virion assembly compartment (vAC) and co-localized with vAC markers of gamma-tubulin (g-tubulin), early endosomes, and viral vAC marker proteins pp65, pp28, and glycoprotein B (gB). WDR5 interacted with multiple virion proteins, including MCP, pp150, pp65, pIRS1, and pTRS1, which may explain the increasing WDR5 accumulation in the vAC during infection. WDR5 was then incorporated into HCMV virions and localized to the tegument layer, as demonstrated by fractionation and immune-gold electron microscopy. Thus, WDR5 is driven to the vAC and incorporated into virions, suggesting that WDR5 facilitates HCMV replication at later stage of virion assembly besides the capsid nuclear egress stage. These data highlight that WDR5 is a potential target for antiviral therapy.

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Serologic and viral genome prevalence of HSV, EBV, and HCMV among healthy adults in Wuhan, China

Cited by 18 publications

References 46 publications

Assessment of infection in newly diagnosed multiple myeloma patients: risk factors and main characteristics

Assessment of infection in newly diagnosed multiple myeloma patients: risk factors and main characteristics

Anterograde Neuronal Circuit Tracers Derived from Herpes Simplex Virus 1: Development, Application, and Perspectives

Human Cytomegalovirus Drives WDR5 to the Virion Assembly Compartment to Facilitate Virion Assembly

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