Serologic false-positive reactions for syphilis in children of adenoidal hypertrophy:2 case reports and review of the literature

Wang, Wei; Fan, Xuzhou; Huang, Xuelian; Yan, Jun; Luan, Jianfeng

doi:10.1080/17843286.2019.1649081

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…False-positive serologic results among cornea donors were high [34], which underlines the importance of the improvement of serologic diagnostic in this field. Last year, different clinical situations confirmed the actual need for further serologic investigations [24,[35][36][37] Dunseth et al underlined the necessity of differentiation between analytical false-positive results of lues tests from clinical false-positive results. A positive syphilis IgG screen with negative RPR and T. pallidum particle agglutination assay (TP-PA) confirmatory testing could be considered an analytical false-positive.…”

Section: Clinical Situations With False-positive Syphilis Reactionsmentioning

confidence: 97%

“…Such cases were noted in patients aged over 60 years, with a history of malignancy and autoimmune diseases [36]. But the false-positive tests for syphilis were noted in children as well [37]. Over all 90% of biologically falsepositive reactions are low titer (≤1:4), but (1%) are high-titer (≥1:32) [24].…”

Section: Clinical Situations With False-positive Syphilis Reactionsmentioning

confidence: 99%

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False-Positive Serologic Reactions for Syphilis

Потекаев¹,

Жукова²,

Хамаганова³

2023

Infectious Diseases

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The epidemiologic situation of syphilitic infection warrants attention to diagnostic methods. Nontreponemal tests (rapid plasma regain, Venereal Disease Research Laboratory) are less reliable, as there are certain situations when false-positive reactions for syphilis antibodies may appear. Variable examinations were performed and proved that it was necessary to assess the titer of antibodies, as well as confirmation of the diagnosis by treponemal tests (fluorescent treponemal antibody, treponema pallidum hemagglutination assay, enzyme immunoassay, Western blot), were obligatory. In recent decades, new methods were elaborated (e.g., BioPlex total screen, tests with β2-GPI-dependent anticardiolipin antibody, the ARCHITECT syphilis treponema pallidum chemiluminescent immunoassay, the Elecsys immunoassay (Roche Diagnostics)). We present the review of publications on syphilis serologic diagnostics and present our own research. We did not find any mention of a false-positive test in atopic dermatitis and present a case of false-positive reactions for syphilis in such patients.

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Section: Clinical Situations With False-positive Syphilis Reactionsmentioning

confidence: 97%

Section: Clinical Situations With False-positive Syphilis Reactionsmentioning

confidence: 99%

False-Positive Serologic Reactions for Syphilis

Потекаев¹,

Жукова²,

Хамаганова³

2023

Infectious Diseases

View full text Add to dashboard Cite

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Clinical application value of Abbott Alinity analyzer in syphilis-specific antibody testing

Hou

Cheng

Shi

2023

Revista Romana De Medicina De Laborator

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Background: We aimed to investigate the clinical application value of Abbott Alinity analyzer in syphilis-specific antibody testing. Methods: A total of 100 patients admitted from June 2021 to June 2022 for early syphilis diagnosis were selected and subjected to Treponema pallidum (TP) antibody testing by chemiluminescent microparticle immunoassay (CMIA) using Abbott Alinity analyzer. With TP particle agglutination (TPPA) retesting as the gold standard for syphilis diagnosis, the signal-to-cutoff (S/CO) ratio of the TP antibody testing was plotted into the receiver operating characteristic curve to determine the diagnostic value of CMIA and CLIA in detecting positive TP antibody and to identify the optimal cutoff point. Results: In the case of S/CO ratio ≥7.00, the patients with positive CMIA were diagnosed with positive findings after TPPA confirmation. With the S/CO ratio of 1.00-4.99, the coincidence rate of CLIA with positive TPPA was 81.82% (45/55), and all patients with positive CLIA had positive results confirmed by TPPA test when the S/CO ratio was >5.00. When the optimal cutoff value of S/CO ratio for TP was determined as 6.98 by CMIA, the sensitivity, specificity, and maximum area under the curve (AUC) were 94%, 88% and 0.91, respectively. At the optimal cutoff value (S/CO ratio: 4.56) determined by CLIA, the sensitivity was 84%, the specificity was 80%, and the maximum AUC was 0.84. Conclusions: In the case of S/CO ratio ≥7.00, both methods have high sensitivity and specificity, which can directly give positive reports and shorten the sample turnaround time.

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Serologic false-positive reactions for syphilis in children of adenoidal hypertrophy:2 case reports and review of the literature

Cited by 2 publications

References 25 publications

False-Positive Serologic Reactions for Syphilis

False-Positive Serologic Reactions for Syphilis

Clinical application value of Abbott Alinity analyzer in syphilis-specific antibody testing

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