Serologic profile and clinical markers of Sjögren syndrome in patients with rheumatoid arthritis

Oliveira, Hugo Franklin Lima de; Souza, Thayse Rodrigues de; Carvalho, Camila Nunes; Duarte, Ângela Luzia Branco Pinto; Carvalho, Alessandra Albuquerque Tavares; Leão, Jair Carneiro; Gueiros, Luiz Alcino Monteiro

doi:10.1016/j.oooo.2015.02.479

Cited by 12 publications

(9 citation statements)

References 30 publications

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“…Xerostomia may be a symptom neglected from individuals and health care professionals 28 . The complaint of dry mouth in RA subjects has varied from 21% to 41.3%, according to different studies 6,11 , but was higher in the present study (66.7%) 11,19 . Maybe, medications, neurologic conditions, alterations in sialochemistry or other unknown reason may be responsible for this symptom.…”

Section: Discussioncontrasting

confidence: 52%

“…Published studies show controversial results about the salivary function of the RA population 2,6,8,9,11 , mainly because of differences in methodology. Most of these studies evaluate RA subjects with secondary autoimmune diseases, like Sjögren's syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of hyposalivation varies from 14.4% to 25.5% in the general population, and it has been reported as 17.4% in the patients with RA 11,16,17 . However, the reduced SFR in RA patients may be a consequence of the large amount of medications taken by these patients.…”

Section: Minor Salivary Glandmentioning

confidence: 99%

“…The degree of salivary function was classified as normal (resting ≥ 0.3; stimulated ≥ 1 mL/min); intermediate (resting > 0.1 to < 0.3; stimulated > 0.7 to < 1.0 mL/min); and hyposalivation (resting ≤ 0.1; stimulated ≤ 0.7 mL/min). 11,13…”

Section: Data Collectionmentioning

confidence: 99%

“…Oral complications of RA may include temporomandibular joint disorders 2,3 , mucosa alterations 4 and complaints of dry mouth 5 . Some studies have evaluated the salivary flow rates (SFR) in RA subjects, not associated with secondary Sjögren's syndrome, but most of them do not distinguish patients with secondary autoimmune diseases 2,6,7,8,9,10,11 .…”

Section: Introductionmentioning

confidence: 99%

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Drugs or disease: evaluating salivary function in RA patients

et al. 2016

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Oral complications of RA may include temporomandibular joint disorders, mucosa alterations and symptoms of dry mouth. The aim of this study was to evaluate the salivary gland function of subjects with rheumatoid arthritis (RA) comparing it to healthy controls. Subjects with other systemic conditions known to affect salivary functions were excluded. A questionnaire was applied for the evaluation of xerostomia. Resting and chewing-stimulated salivary flow rates (SFR) were obtained under standard conditions. There were 145 subjects included of the study (104 RA and 38 controls). About 66.7% of the RA subjects and 2.4% in control group presented xerostomia. The median resting SFR were 0.24 ml/min for RA subjects and 0.40 mL/min for controls (p = 0.04). The median stimulated SFR were 1.31 mL/min for RA subjects and 1.52 ml/min for controls (p = 0.33). No significant differences were found between resting and stimulated SFR of RA subjects not using xerogenic medications and controls. There was significantly higher number of subjects presenting hyposalivation in the RA group than among controls, even when subjects using xerogenic medications were eliminated from the analysis. In conclusion, hyposalivation and xerostomia were more frequent among RA subjects not using xerogenic medication than among controls, although there were no significant differences in the median SFR between groups.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Minor Salivary Glandmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Drugs or disease: evaluating salivary function in RA patients

et al. 2016

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Disease activity and patient-reported outcomes in patients with rheumatoid arthritis and Sjögren’s syndrome enrolled in a large observational US registry

Harrold

Shan²,

Rebello³

et al. 2020

Rheumatol Int

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The objective of this study was to compare rheumatoid arthritis (RA) disease activity and patient-reported outcomes (PROs) in a national sample of patients with RA with/without Sjögren's syndrome (SS). Adults with RA from a large observational US registry (Corrona RA) with known SS status between 22 April 2010 and 31 July 2018 and a visit 12 (± 3) months after index date were identified (n = 36,256/52,757). SS status: determined from a yes/no variable reported at enrolment into the Corrona RA registry and follow-up visits. Index date: date that SS status was recorded (yes/no). Patients received biologic or targeted synthetic disease-modifying antirheumatic drugs as part of standard care. Patients with RA only were followed for ≥ 12 months to confirm the absence of SS. Patients were frequency-and propensity-score matched (PSM) 1:1 and stratified by disease duration and treatment response-associated variables, respectively. Clinical Disease Activity Index (CDAI) and PROs 12 months after index visit were compared in patients with and without SS. Baseline characteristics in 283 pairs of PSM patients were balanced. Mean change in CDAI score was numerically lower in patients with RA and SS than patients with RA only (8.8 vs 9.3). Reductions in PROs of pain, fatigue and stiffness were two-to threefold lower for patients with RA and SS versus RA only. Reductions in RA disease activity and RA-related PROs were lower in patients with RA and SS versus those with RA only. Our data indicate that SS adds to treatment challenges; physicians may wish to consider SS status when managing patients with RA.

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Correlations between clinical parameters of dry eye disease and serologic profiles in Sjögren’s syndrome

Lee

Jeon

Hyon

2022

Graefes Arch Clin Exp Ophthalmol

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Serologic profile and clinical markers of Sjögren syndrome in patients with rheumatoid arthritis

Abstract: Secondary SS seems to be a cluster of oral and ocular symptoms among patients with RA. Anti-CCP and RF are not relevant to evaluate the presence of SS among these patients.

Cited by 12 publications

References 30 publications

Drugs or disease: evaluating salivary function in RA patients

Drugs or disease: evaluating salivary function in RA patients

Disease activity and patient-reported outcomes in patients with rheumatoid arthritis and Sjögren’s syndrome enrolled in a large observational US registry

Correlations between clinical parameters of dry eye disease and serologic profiles in Sjögren’s syndrome

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