Serological Comparisons Among Hart Park Virus and Strains of Flanders Virus

Boyd, Kenneth R.

doi:10.1128/iai.5.6.933-937.1972

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…One monophyletic cluster identified by this approach includes a geographically and ecologically diverse group of viruses termed the Hart Park group because of the close serological relationship of one of the members, Flanders virus, to Hart Park virus. Both of these viruses have been isolated from mosquitoes and infect birds in North America (Boyd, 1972). The Hart Park phylogenetic group also includes Wongabel virus which was isolated from biting midges (Culicoides spp.)…”

Section: The Rhabdoviridaementioning

confidence: 99%

Rhabdovirus accessory genes

et al. 2011

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The Rhabdoviridae is one of the most ecologically diverse families of RNA viruses with members infecting a wide range of organisms including placental mammals, marsupials, birds, reptiles, fish, insects and plants. The availability of complete nucleotide sequences for an increasing number of rhabdoviruses has revealed that their ecological diversity is reflected in the diversity and complexity of their genomes. The five canonical rhabdovirus structural protein genes (N, P, M, G and L) that are shared by all rhabdoviruses are overprinted, overlapped and interspersed with a multitude of novel and diverse accessory genes. Although not essential for replication in cell culture, several of these genes have been shown to have roles associated with pathogenesis and apoptosis in animals, and cell-to-cell movement in plants. Others appear to be secreted or have the characteristics of membrane-anchored glycoproteins or viroporins. However, most encode proteins of unknown function that are unrelated to any other known proteins. Understanding the roles of these accessory genes and the strategies by which rhabdoviruses use them to engage, divert and re-direct cellular processes will not only present opportunities to develop new anti-viral therapies but may also reveal aspects of cellar function that have broader significance in biology, agriculture and medicine.

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Section: The Rhabdoviridaementioning

confidence: 99%

Rhabdovirus accessory genes

et al. 2011

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“…First, Wongabel, Parry Creek, Flanders and Ngaingan viruses formed a distinct cluster, with high levels (93 %) of quartet puzzling support. We refer to this as the 'Hart Park' group, based on the serologic grouping of Flanders virus in the Hart Park serological group (Boyd, 1972;Calisher et al, 1989). Second, a tentatively named 'Almpiwar' group, containing Almpiwar virus, Humpty Doo virus, Charleville virus and Oak-Vale virus, was also identified.…”

Section: Sequence Analysis Of L Polymerase Block Iiimentioning

confidence: 99%

Phylogenetic relationships among rhabdoviruses inferred using the L polymerase gene

Bourhy

Cowley

Larrous

et al. 2005

Journal of General Virology

145

135

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RNA viruses of the family Rhabdoviridae include arthropod-borne agents that infect plants, fish and mammals, and also include a variety of non-vector-borne mammalian viruses. Herein is presented a molecular phylogenetic analysis, the largest undertaken to date, of 56 rhabdoviruses, including 20 viruses which are currently unassigned or assigned as tentative species within the Rhabdoviridae. Degenerate primers targeting a region of block III of the L polymerase gene were defined and used for RT-PCR amplification and sequencing. A maximum-likelihood phylogenetic analysis of a 158-residue L polymerase amino acid sequence produced an evolutionary tree containing the six recognized genera of the Rhabdoviridae and also enabled us to identify four more monophyletic groups of currently unclassified rhabdoviruses that we refer to as the 'Hart Park', 'Almpiwar', 'Le Dantec' and 'Tibrogargan' groups. The broad phylogenetic relationships among these groups and genera also indicate that the evolutionary history of rhabdoviruses was strongly influenced by mode of transmission, host species (plant, fish or mammal) and vector (orthopteran, homopteran or dipteran).

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“…Flanders virus (FLAV) and Hart Park virus (HPV) are two closelyrelated members of the Hart Park serogroup of the family Rhabdoviridae that are maintained in mosquito-passerine bird transmission cycles in the eastern and western United States, respectively (Whitney, 1964;Johnson, 1965;Kokernot et al, 1969;Crane et al, 1970;Main et al, 1979;Main, 1981). Viruses in the Hart Park serogroup were initially classified together based on antigenic cross-reactivity in complement fixation, neutralization, immunodiffusion and/or immunofluorescence assays (Boyd, 1972;Frazier and Shope, 1979). In addition to FLAV and HPV, other members in earlier classifications of the serogroup included Mosqueiro virus (MQOV), a virus first isolated in Brazil, and two African viruses, Mossuril virus (MOSV) and Kamese virus (KAMV) (Tesh et al, 1983;Calisher et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Gene duplication and phylogeography of North American members of the Hart Park serogroup of avian rhabdoviruses

et al. 2014

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Flanders virus (FLAV) and Hart Park virus (HPV) are rhabdoviruses that circulate in mosquito-bird cycles in the eastern and western United States, respectively, and constitute the only two North American representatives of the Hart Park serogroup. Previously, it was suggested that FLAV is unique among the rhabdoviruses in that it contains two pseudogenes located between the P and M genes, while the cognate sequence for HPV has been lacking. Herein, we demonstrate that FLAV and HPV do not contain pseudogenes in this region, but encode three small functional proteins designated as U1, U2, and U3 that apparently arose by gene duplication. To further investigate the U1-U2-U3 region, we conducted the first large-scale evolutionary analysis of a member of the Hart Park serogroup by analyzing over 100 spatially and temporally distinct FLAV isolates. Our phylogeographic analysis demonstrates that although FLAV appears to be slowly evolving, phylogenetically divergent lineages co-circulate sympatrically.

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Serological Comparisons Among Hart Park Virus and Strains of Flanders Virus

Cited by 10 publications

References 11 publications

Rhabdovirus accessory genes

Rhabdovirus accessory genes

Phylogenetic relationships among rhabdoviruses inferred using the L polymerase gene

Gene duplication and phylogeography of North American members of the Hart Park serogroup of avian rhabdoviruses

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