Serological Response to
            <i>Pasteurella multocida</i>
            NanH Sialidase in Persistently Colonized Rabbits

Sánchez, Susan; Mizan, Shaikh; Quist, Charlotte F.; P, Schröder; Juneau, Michelle; Dawe, Donald L.; Ritchie, Branson W.; Lee, Margie D.

doi:10.1128/cdli.11.5.825-834.2004

Cited by 16 publications

(16 citation statements)

References 36 publications

(42 reference statements)

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“…Pasteurella multocida (P. multocida) is a microbe, which occurs naturally in the respiratory tract of some animal species; however, it can be a virulent pathogen that infects other animal hosts [ 1 ]. Pasteurellosis is a disease that affects rabbits, characterized by rhinitis, pneumonia, orchitis, otitis media, septicemia, and abscess formation [ 2 ]; however, infection with P. multocida may be asymptomatic [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory, Immunomodulatory, and Antioxidant Activities of Allicin, Norfloxacin, or Their Combination against Pasteurella multocida Infection in Male New Zealand Rabbits

Alam

Fawzi

Alkhalf

et al. 2018

Oxidative Medicine and Cellular Longevity

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The present study investigated the efficacy of allicin as an antibacterial, anti-inflammatory, antioxidant, and immunostimulant agent in reducing the severity of Pasteurella multocida (P. multocida) type B infection in rabbits. Fifty New Zealand rabbits, 5 weeks old, were divided equally into five groups. Except for group 1, all groups were intranasally infected with P. multocida type B (2 × 105 colony forming units/ml/rabbit). Then, group 3 rabbits were orally treated with allicin (50 mg/kg BW) for 5 days, group 4 rabbits received a single oral dose of norfloxacin 30% (100 mg/kg BW), while group 5 rabbits were treated with a combination of norfloxacin and allicin. Hematological, serum biochemical, inflammatory cytokine, immunological, and histopathological analyses were performed. Results revealed that rabbits, infected with P. multocida type B, exhibited macrocytic hypochromic anemia and leukocytosis with a significant elevation in the phagocytic percentage and index. Moreover, significant reductions in serum total protein, albumin, globulin, and immunoglobulin (IgG and IgM) levels were observed in infected rabbits. Infected rabbits showed significant increases in serum inflammatory cytokine (TNF-α and IL-6), alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, and serum bilirubin (total, direct, and indirect) levels. Further, P. multocida infection induced oxidative stress as demonstrated by the significant reduction in serum levels of reduced glutathione and superoxide dismutase enzyme and marked elevation in serum malondialdehyde. Treatment with allicin, norfloxacin, or their combination significantly ameliorated the alterations in all studied parameters. In conclusion, allicin could ameliorate the inflammation and oxidative stress, induced by P. multocida type B infection in rabbits.

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Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory, Immunomodulatory, and Antioxidant Activities of Allicin, Norfloxacin, or Their Combination against Pasteurella multocida Infection in Male New Zealand Rabbits

Alam

Fawzi

Alkhalf

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Pasteurella multocida , a virulent and readily transmitted coccobacillus, is one of the most significant bacterial diseases of rabbits and causes considerable economic losses in large production units world-wide [ 3 , 4 ]. Clinical signs in rabbits include rhinitis with purulent nasal discharge, pneumonia, otitis media, pyometra, orchitis, abscesses, oculoconjunctivitis, and septicaemia [ 5 , 6 ]; although infection may also be asymptomatic [ 7 ]. Of the 5 serogroups, serogroup A and to a lesser extent serogroup D strains are considered to be causative agents of pasteurellosis in rabbits [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits

et al. 2014

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BackgroundPasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species.ResultsThirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1–3), (1–6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1–3), (1–6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics.ConclusionsIn our study, (1–3), (1–6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-014-0276-6) contains supplementary material, which is available to authorized users.

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“…Prior to the study, swabs of ear lesions were cultured for possible bacterial infections ( n = 42). These swab samples were streaked onto both selective (Knight's and Avril's agar) and nonselective (blood and chocolate) agars for microbiological culturing, especially for Pasteurella multocida 14 . Bacterial cultures revealed no growth.…”

mentioning

confidence: 99%

Use of selamectin for the treatment of psoroptic and sarcoptic mite infestation in rabbits

Kurtdede

Karaer

Acar

et al. 2007

Veterinary Dermatology

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Selamectin, a novel avermectin compound, was evaluated for its efficacy against naturally occurring infestations of Psoroptes cuniculi and Sarcoptes scabiei. A total of 42 New Zealand rabbits with psoroptic mange and 37 Angora rabbits with sarcoptic mange were used in the present study. On day 0, infested rabbits were treated topically with either selamectin at minimum dose of 6 mg kg(-1) (6-18 mg kg(-1) for New Zealand rabbits, n = 31 and 10-12 mg kg(-1) for Angora rabbits, n = 23) or vehicle only (control groups, n = 11 for New Zealand rabbits, n = 14 for Angora rabbits). The efficacy of selamectin was assessed both clinically and parasitologically by the presence or absence of viable mites. Rabbits were scraped for sarcoptic mites on days 7, 14, 28, 42 and 56 and had otoscopeic and/or microscopic examination for the detection of Psoroptes mites on days 7, 14, 42 and 56. Fisher's exact test was used to assess differences between the vehicle and selamectin treatment in the number of rabbits without mites (cure rates) on each assessment date. It was found that significantly fewer selamectin-treated rabbits had mites detected on skin scrapings (for S. scabiei) or otoscopeic and/or microscopic examination (for P. cuniculi) (P < 0.01) than the vehicle group. Results of the present study suggest that selamectin is effective against naturally infestations of P. cuniculi and S. scabiei in rabbits.

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Serological Response to Pasteurella multocida NanH Sialidase in Persistently Colonized Rabbits

Cited by 16 publications

References 36 publications

Anti‐Inflammatory, Immunomodulatory, and Antioxidant Activities of Allicin, Norfloxacin, or Their Combination against Pasteurella multocida Infection in Male New Zealand Rabbits

Anti‐Inflammatory, Immunomodulatory, and Antioxidant Activities of Allicin, Norfloxacin, or Their Combination against Pasteurella multocida Infection in Male New Zealand Rabbits

Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits

Use of selamectin for the treatment of psoroptic and sarcoptic mite infestation in rabbits

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