Séroprévalence et facteurs de risque de l’infection par le virus herpès humain 8 dans le Centre-Est tunisien

Hannachi, Naila; Fredj, Nadia Ben; Samoud, S.; Ferjani, Asma; Khlif, A.; Boughammoura, L.; Soussi, Sonia; Aouni, Mahjoub; Skouri, H.; Boukadida, Jalel

doi:10.1016/j.patbio.2011.10.008

Cited by 9 publications

(7 citation statements)

References 30 publications

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“…Since the prevalence of HHV-8 is low, our results do not support the routine blood banks screening for HHV-8 13 .…”

Section: Discussioncontrasting

confidence: 81%

“…Based on HHV8 seropositivity, the world has been divided into three regions: those with less than 5% seroprevalence, such as North America and Northern Europe; those with intermediate seroprevalence, ranging from 5% to 20% in Mediterranean and Middle Eastern countries, to more than 50% in many African populations and regions, such as Sudan. [8][9][10][11][12] .HHV-8 infection does not appear to be widespread in the Tunisian community, and the observed seroprevalence of anti-HHV-8 in apparently healthy persons was 13.8 %, compared to 17-40 % in patients having kidney renal transplants 10,13 . HHV-8 is spread from one person mainly through saliva, but infection can also occur through sexual contact 14 , blood transfusion 15 and by solid organ transplantation (SOT) 16 .…”

Section: Introductionmentioning

confidence: 99%

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Human herpesvirus-8 infection in Tunisian adult acute leukemia patients

Handous¹,

Hannachi²,

Achour³

et al. 2023

Afr H. Sci.

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Background: Human herpesvirus 8 (HHV-8) has been linked to the development of Kaposi's sarcoma (KS)and multiple other hematologic malignant disorders. However, the role of HHV-8 in acute leukemia patients is unknown. Objectives: The objective of this study was to determine the prevalence of HHV-8 in Tunisian acute leukemia patients and in healthy blood donors. Methods: An indirect immunofluorescence test was used to detect the presence of anti-HHV8 antibodies. Nested PCR was used for the detection of HHV-8 DNAemia in samples of plasma. Results: The seroprevalence of HHV-8 was significantly higher in acute leukemia patients (21,4% ,15/70) than in healthy blood donors (7,1%, 5/70), (p= 0.02). Gender, type of disease, status of disease, prior blood transfusion, and outcome were not associated with HHV-8 seroprevalence. However, among acute leukemia patients, HHV-8 seroprevalence was statistically associated with older age > 40 years of age, (p=0.002). HHV-8 DNAemia was detected (1,4%) in only one patient of acute myeloid leukemia (AML) and none of the healthy blood donors. Conclusions: The seroprevalence of HHV-8 infection in Tunisian adult acute leukemia patients was three times as high compared to healthy blood donors, suggesting that patients with acute leukemia might be at increased risk of HHV-8 infection. Keywords: Human herpesvirus 8; acute leukemia patients; blood donors; prevalence.

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“…Since the prevalence of HHV-8 is low, our results do not support the routine blood banks screening for HHV-8 13 .…”

Section: Discussioncontrasting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Human herpesvirus-8 infection in Tunisian adult acute leukemia patients

Handous¹,

Hannachi²,

Achour³

et al. 2023

Afr H. Sci.

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“…The relationship of many members of this family with cardiovascular disease has been assessed by measuring different markers of subclinical atherosclerosis and inflammation, and an association has been observed with cytomegalovirus, herpes simplex virus type 2 (HSV-2) and varicella-zoster virus in HIV-infected patients [11]–[13]. Human herpesvirus 8 (HHV-8) is a sexually transmitted pathogen highly prevalent among men who have sex with men [14], although additional transmission routes via saliva, infection during childhood, as well as by blood transfusion, have also been described [15], [16]. HHV-8 is a lymphotropic and vasculotropic herpesvirus linked with Kaposi's sarcoma, and possibly with pulmonary hypertension in HIV-infected patients [17].…”

Section: Introductionmentioning

confidence: 99%

Coinfection with Human Herpesvirus 8 Is Associated with Persistent Inflammation and Immune Activation in Virologically Suppressed HIV-Infected Patients

et al. 2014

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ObjectivesInfection with co-pathogens is one of the postulated factors contributing to persistent inflammation and non-AIDS events in virologically-suppressed HIV-infected patients. We aimed to investigate the relationship of human herpesvirus-8 (HHV-8), a vasculotropic virus implicated in the pathogenesis of Kaposi's sarcoma, with inflammation and subclinical atherosclerosis in HIV-infected patients.MethodsProspective study including virologically suppressed HIV-infected patients. Several blood biomarkers (highly-sensitive C-reactive protein [hsCRP], tumour necrosis factor-α, interleukin-6, monocyte chemoattractant protein-1, vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, malondialdehyde, plasminogen activator inhibitor [PAI-1], D-dimer, sCD14, sCD163, CD4/CD38/HLA-DR, and CD8/CD38/HLA-DR), serological tests for HHV-8 and the majority of herpesviruses, carotid intima-media thickness, and endothelial function through flow-mediated dilatation of the brachial artery were measured.ResultsA total of 136 patients were included, 34.6% of them infected with HHV-8. HHV-8-infected patients were more frequently co-infected with herpes simplex virus type 2 (HSV-2) (P<0.001), and less frequently with hepatitis C virus (HCV) (P = 0.045), and tended to be older (P = 0.086). HHV-8-infected patients had higher levels of hsCRP (median [interquartile range], 3.63 [1.32–7.54] vs 2.08 [0.89–4.11] mg/L, P = 0.009), CD4/CD38/HLA-DR (7.67% [4.10–11.86]% vs 3.86% [2.51–7.42]%, P = 0.035) and CD8/CD38/HLA-DR (8.02% [4.98–14.09]% vs 5.02% [3.66–6.96]%, P = 0.018). After adjustment for the traditional cardiovascular risk factors, HCV and HSV-2 infection, the associations remained significant: adjusted difference between HHV-8 positive and negative patients (95% confidence interval) for hsCRP, 74.19% (16.65–160.13)%; for CD4/CD38/HLA-DR, 89.65% (14.34–214.87)%; and for CD8/CD38/HLA-DR, 58.41% (12.30–123.22)%. Flow-mediated dilatation and total carotid intima-media thickness were not different according to HHV-8 serostatus.ConclusionIn virologically suppressed HIV-infected patients, coinfection with HHV-8 is associated with increased inflammation and immune activation. This might contribute to increase the risk of non-AIDS events, including accelerated atherosclerotic disease.

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“…In Tunisia, the sero-prevalence of HHV8 was 13.8 % in blood donors, 13 % in pregnant women, and 12 % in children [ 120 ]. HHV8 was found in 17 % of kidney transplant patients [ 121 ].…”

Section: Methodsmentioning

confidence: 99%

A review of the infection-associated cancers in North African countries

Hussein

Anwar

Attaleb

et al. 2016

Infect Agents Cancer

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Cancer is typically classified as a leading non-communicable disease; however, infectious agents, such as Helicobacter pylori (H. pylori), hepatitis B virus (HBV), hepatitis C virus (HCV) and human papilloma virus (HPV), contribute significantly to the pathogenesis of various cancers. Less developed countries, including countries of the North African (NA) region, endure the highest burden of infection-related cancers. The five most common infection-associated cancers in NA in order of incidence are bladder cancer, cervical cancer, liver cancer, stomach cancer, and nasopharyngeal carcinoma. This review aims to outline the epidemiologic pattern of infection-associated cancers in five NA countries (namely: Morocco, Algeria, Tunisia, Libya and Egypt) highlighting the similarities and differences across the region. The present study employed an initial literature review of peer-reviewed articles selected from PubMed, ScienceDirect and World Health Organization (WHO) databases based on key word searches without restriction on publication dates. Original research articles and reports written in French, as well as data from institutional reports and regional meeting abstracts were also included in this extensive review. Egypt, Libya, Tunisia, Algeria and Morocco were selected to be the focus of this review.

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Séroprévalence et facteurs de risque de l’infection par le virus herpès humain 8 dans le Centre-Est tunisien

Cited by 9 publications

References 30 publications

Human herpesvirus-8 infection in Tunisian adult acute leukemia patients

Human herpesvirus-8 infection in Tunisian adult acute leukemia patients

Coinfection with Human Herpesvirus 8 Is Associated with Persistent Inflammation and Immune Activation in Virologically Suppressed HIV-Infected Patients

A review of the infection-associated cancers in North African countries

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