Seroprevalence of Crimean‐Congo haemorrhagic fever among three selected risk human groups in disease‐endemic region of Pakistan

Shahid, Muhammad Furqan; Shabbir, Muhammad Zubair; Ashraf, Kamran; Ali, Mohsin; Yaqub, Saima; Mukhtar, Nadia; Khan, Adnan; Tahir, Zarfishan; Yaqub, Tahir

doi:10.1111/zph.12704

Cited by 7 publications

(14 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results obtained in this serosurvey, taken together with previous findings in Spain, indirectly suggest that the risk of exposure to CCHFV should be more linked to high‐risk activities in risk hotspots rather than only to living close to or in high‐risk areas (Gunes et al., 2009; Shahid et al., 2020 ). Delivering thus the appropriate information on tick bite prevention recommendations to the adequate stakeholders may also reduce the risk for those whose activities are of high risk and carried out in high‐risk regions.…”

Section: Resultssupporting

confidence: 68%

The spatial pattern of human exposure to Crimean–Congo haemorrhagic fever virus is not consistent with red deer‐based risk predictions

Frías

Cuadrado‐Matías

Jarilla‐Fernandez

et al. 2022

Transbounding Emerging Dis

View full text Add to dashboard Cite

The objective of this study was to evaluate the spatial risk of exposure to Crimean-Congo haemorrhagic fever virus (CCHFV) infection of healthy blood donors in an enzootic region with a predicted risk gradient based on a virus-animal interaction risk model. We designed a cross-sectional study to test if the exposure pattern of the human population to CCHFV spatially matches the predicted risk. We randomly selected 1384 donors from different risk gradients and analyzed their sera searching for CCHFV antibodies. None of the selected blood donors showed exposure to CCHFV.This study shows that exposure risk spatial patterns, as predicted from animal-tickvirus models, does not necessarily match the pattern of human-infected tick interactions leading to CCHFV infection and CCHF cases, at least in a region of predicted moderate infection risk. The findings suggest that future studies should bear the potential drivers of tick-human encounter rates into account to more accurately predict risks.

show abstract

Section: Resultssupporting

confidence: 68%

The spatial pattern of human exposure to Crimean–Congo haemorrhagic fever virus is not consistent with red deer‐based risk predictions

Frías

Cuadrado‐Matías

Jarilla‐Fernandez

et al. 2022

Transbounding Emerging Dis

View full text Add to dashboard Cite

show abstract

“…The 33 studies included in the analyses, all of them published from 2007 to 2022, are summarized in Table 1 [ 13 , 14 , 21 , 22 , 23 , 24 , 25 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Among them, 17 (51.51%) were published after 2014, when the WHO first identified CCHF as a global health threat [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…The majority of studies (10 out of 33, 30.30%) reported data from Turkey [ 21 , 22 , 43 , 44 , 47 , 53 , 56 , 58 , 60 , 63 ], for a total of 5186 subjects (20.43% of the total sample, range 75 to 2319 patients per paper), followed by Iran (5 studies, 15.15%) for a total 760 subjects (3.76% of the total sample, range 104 to 250) [ 23 , 39 , 46 , 52 , 59 ], and Greece (3 studies including a total of 2095 subjects, 10.37% of the total sample, range 207–1611) [ 40 , 41 , 62 ]. Pakistan (1505 subjects, 7.45% of the total sample) [ 48 , 49 ] and South Africa (1427 subjects, 7.07% of the total sample) [ 25 , 45 ] provided 2 studies each (6.06%). One single report was provided from India (No.…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence of Crimean Congo Hemorrhagic Fever Virus in Occupational Settings: Systematic Review and Meta-Analysis

Riccò,

Baldassarre,

Corrado

et al. 2023

TropicalMed

View full text Add to dashboard Cite

Crimean Congo Hemorrhagic Fever (CCHF) Virus can cause a serious human disease, with the case fatality ratio previously estimated to be 30–40%. Our study summarized seroprevalence data from occupational settings, focusing on the following occupational groups: animal handlers, abattoir workers, farmers, healthcare workers, veterinarians, rangers, and hunters. Systematic research was performed on three databases (PubMed, EMBASE, MedRxiv), and all studies reporting seroprevalence rates (IgG-positive status) for CCHF virus were retrieved and their results were reported, summarized, and compared. We identified a total of 33 articles, including a total of 20,195 samples, i.e., 13,197 workers from index occupational groups and 6998 individuals from the general population. Pooled seroprevalence rates ranged from 4.751% (95% confidence intervals (95% CI) 1.834 to 11.702) among animal handlers, to 3.403% (95% CI 2.44 to 3.932) for farmers, 2.737% (95% CI 0.896 to 8.054) among rangers and hunters, 1.900% (95% CI 0.738 to 4.808) for abattoir workers, and 0.644% (95% CI 0.223–1.849) for healthcare workers, with the lowest estimate found in veterinarians (0.283%, 95% CI 0.040–1.977). Seroprevalence rates for abattoir workers (odds ratio (OR) 4.198, 95% CI 1.060–16.464), animal handlers (OR 2.399, 95% CI 1.318–4.369), and farmers (OR 2.280, 95% CI 1.419 to 3.662) largely exceeded the official notification rates for CCHF in the general population. CCHF is reasonably underreported, and pooled estimates stress the importance of improving the adherence to personal protective equipment use and appropriate preventive habits.

show abstract

“…Furthermore, Punjab Province, particularly in the upper region, has large rangelands for animal grazing, a semiarid climate with high precipitation, and abundant livestock, which also provide a thriving tick habitat and can subsequently increase CCHFV prevalence ( 26 ). Previous studies have reported high CCHFV IgG seroprevalence in humans from Upper Punjab ( 27 , 28 ), which suggests effective control measures are especially needed in this area to inhibit tick infestation of livestock and prevent CCHF outbreaks.…”

Section: Discussionmentioning

confidence: 97%

Crimean-Congo Hemorrhagic Fever Virus Diversity and Reassortment, Pakistan, 2017–2020

Umair,

Rehman,

Whitmer

et al. 2024

Emerg. Infect. Dis.

View full text Add to dashboard Cite

Sporadic cases and outbreaks of Crimean-Congo hemorrhagic fever (CCHF) have been documented across Pakistan since 1976; however, data regarding the diversity of CCHF virus (CCHFV) in Pakistan is sparse. We whole-genome sequenced 36 CCHFV samples collected from persons infected in Pakistan during 2017–2020. Most CCHF cases were from Rawalpindi (n = 10), followed by Peshawar (n = 7) and Islamabad (n = 4). Phylogenetic analysis revealed the Asia-1 genotype was dominant, but 4 reassorted strains were identified. Strains with reassorted medium gene segments clustered with Asia-2 (n = 2) and Africa-2 (n = 1) genotypes; small segment reassortments clustered with the Asia-2 genotype (n = 2). Reassorted viruses showed close identity with isolates from India, Iran, and Tajikistan, suggesting potential crossborder movement of CCHFV. Improved and continuous human, tick, and animal surveillance is needed to define the diversity of circulating CCHFV strains in Pakistan and prevent transmission.

show abstract

Seroprevalence of Crimean‐Congo haemorrhagic fever among three selected risk human groups in disease‐endemic region of Pakistan

Abstract: The CCHF is caused by Crimean-Congo haemorrhagic fever virus (CCHFV), an RNA virus of the genus orthonairovirus under family Nairoviridae (Adams et al., 2017). Tick bite is considered as the primary factor along with direct contact with viraemic farm

Cited by 7 publications

References 22 publications

The spatial pattern of human exposure to Crimean–Congo haemorrhagic fever virus is not consistent with red deer‐based risk predictions

The spatial pattern of human exposure to Crimean–Congo haemorrhagic fever virus is not consistent with red deer‐based risk predictions

Seroprevalence of Crimean Congo Hemorrhagic Fever Virus in Occupational Settings: Systematic Review and Meta-Analysis

Crimean-Congo Hemorrhagic Fever Virus Diversity and Reassortment, Pakistan, 2017–2020

Contact Info

Product

Resources

About