Serotonergic and noradrenergic receptors in the rat brain: Modulation by chronic exposure to ovarian hormones

Biegon, Anat; Reches, Avinoam; Snyder, Lenore; McEwen, Bruce S.

doi:10.1016/0024-3205(83)90053-x

Cited by 234 publications

(76 citation statements)

References 20 publications

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“…The effect of estradiol to increase 5-HT 2A receptors specific binding of ovariectomized rats was also previously observed using the ligands [ 3 H]-RP62203 (Fink and Sumner 1996), [ 3 H]ketanserin (Sumner and Fink 1995) and [ 3 H]spiperone (Biegon et al 1983). The present data confirm these results and these changes were paralleled by a similar pattern of changes of 5-HT 2A receptor mRNA levels.…”

Section: Discussionsupporting

confidence: 66%

Modulation by Estrogen-Receptor Directed Drugs of 5-Hydroxytryptamine-2A Receptors in Rat Brain

Cyr

Landry

Paolo

2000

Neuropsychopharmacology

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Section: Discussionsupporting

confidence: 66%

Modulation by Estrogen-Receptor Directed Drugs of 5-Hydroxytryptamine-2A Receptors in Rat Brain

Cyr

Landry

Paolo

2000

Neuropsychopharmacology

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“…Therefore, it can be concluded that the 5-HT 1A receptor subtype is a mediator of the antidepressant-like action of E 2 . Evidences in favor of this hypothesis are the results derived from in vitro and in vivo studies, showing that the 5-HT 1A receptor subtype is a target of estrogens and some estrogen-like compounds (Bethea et al, 1998;Biegon et al, 1983;Mize and Alper, 2000;Mize et al, 2001;Raap et al, 2000;Uphouse, 2000). Indeed, Lu and Bethea (2002) demonstrated that E 2 induces the desensitization of 5-HT 1A receptors in the DRN of monkeys.…”

Section: Discussionmentioning

confidence: 99%

Participation of the 5-HT1A Receptor in the Antidepressant-Like Effect of Estrogens in the Forced Swimming Test

Estrada‐Camarena

Fernández‐Guasti

López‐Rubalcava

2005

Neuropsychopharmacol

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The aim of the present study was to explore the possible participation of the 5-HT 1A receptor in the antidepressant-like action of two estrogenic compounds: 17b-estradiol (E 2 ) and ethynil-estradiol (EE 2 ) in the FST. Ovariectomized female Wistar rats were used in all experiments. As a positive control, the effect of the 5-HT 1A receptor agonist, 8-hydroxy-2-(di-n)-propil-aminotetraline (8-OH-DPAT; 0.0625, 0.125, 0.25 and 0.5 mg/kg) alone or in combination with WAY 100635 (0.5 and 1.0 mg/kg) was analyzed in the FST. In order to analyze the participation of the 5-HT 1A receptor in the antidepressant-like actions of estrogens, the effect of the selective antagonist WAY 100635 (0.5 and 1.0 mg/kg) in combination with E 2 (10 mg/rat) and EE 2 (5 mg/rat) was studied in the FST. In this case, WAY 100635 was administered either simultaneously with the estrogens (48 h before the FST test) or 30 min before the FST. On the other hand, a suboptimal dose of 8-OH-DPAT (0.0625 mg/kg), combined with a noneffective dose of E 2 (2.5 mg/rat) or EE 2 (1.25 mg/rat), was tested in the FST. The results showed that 8-OH-DPAT (0.25 and 0.5 mg/kg), E 2 (10 mg/rat), and EE 2 (5 mg/rat), by themselves, exerted an antidepressant-like action. The antagonist to the 5-HT 1A receptor WAY 100635, when applied together with 8-OH-DPAT or E 2 , blocked their antidepressant-like actions, but not the one induced by EE 2 . Interestingly, when the antagonist was applied 30 min before the FST, it was able to cancel the actions of EE 2 on immobility behavior, and had no effect on the actions of E 2. Finally, when a subthreshold dose of 8-OH-DPAT was combined with a noneffective dose of either E 2 or EE 2 , an antidepressant-like action was observed. The results support the notion that the 5-HT 1A receptor is one of the mediators of the antidepressant-like action of E 2 , and could indirectly contribute to the one induced by EE 2 .

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“…On the other hand, in vitro studies demonstrate that estrogens can interact, at several levels, with the dopaminergic, the noradrenergic, and the serotonergic systems (Attali et al, 1997;Bethea et al, 1998;Biegon et al, 1983;Cyr et al, 2000;McEwen, 1999;Rubinow et al, 1998). For example, estrogens can inhibit the function of the monoaminergic transporter (Ghraf et al, 1983;Michel et al, 1987;Wilson et al, 1988) and interact with either 5-HT 1A , 5-HT 2A , or b-adrenergic receptors in several brain areas (Biegon et al, 1983;Fink et al, 1996;Kendall et al, 1982;Mize and Alper, 2000;Ö sterlund et al, 1999;Raap et al, 2000;Sumner and Fink, 1995). Interestingly, estrogenic compounds modify those neurotransmitter systems that are targets of antidepressant treatments.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-Like Effect of Different Estrogenic Compounds in the Forced Swimming Test

Estrada‐Camarena

Fernández‐Guasti

López‐Rubalcava

2002

Neuropsychopharmacol

185

124

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The present study evaluated the possible antidepressant-like action of the natural estrogen 17b-estradiol (E 2 , 2.5-10 mg/rat), the synthetic steroidal estrogen ethinyl-estradiol (EE 2 , 1.25-10.0 mg/rat), and the nonsteroidal synthetic estrogen, diethyl-stilbestrol (DES, 0.25-1.0 mg/ rat) in ovariectomized adult female Wistar rats using the forced swimming test (FST). The behavioral profile induced by the estrogens was compared with that induced by the antidepressants fluoxetine (FLX, 2.5-10 mg/kg) and desipramine (DMI, 2.5-10 mg/kg). In addition, the temporal course of the antidepressant-like action of the estrogenic compounds was analyzed. FLX and DMI induced an antidepressant-like effect characterized by a reduced immobility and increased swimming for FLX and decreased immobility and increased climbing for DMI. Both E 2 and EE 2 produced a decrease in immobility and an increase in swimming, suggesting an antidepressant-like action. DES did not affect the responses in this animal model of depression at any dose tested. The time course analysis of the actions of E 2 (10 mg/rat) and EE 2 (5 mg/rat) showed that both compounds induced an antidepressant-like effect observed 1 h after their injection lasting for 2-3 days.

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Serotonergic and noradrenergic receptors in the rat brain: Modulation by chronic exposure to ovarian hormones

Cited by 234 publications

References 20 publications

Modulation by Estrogen-Receptor Directed Drugs of 5-Hydroxytryptamine-2A Receptors in Rat Brain

Modulation by Estrogen-Receptor Directed Drugs of 5-Hydroxytryptamine-2A Receptors in Rat Brain

Participation of the 5-HT1A Receptor in the Antidepressant-Like Effect of Estrogens in the Forced Swimming Test

Antidepressant-Like Effect of Different Estrogenic Compounds in the Forced Swimming Test

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